Vorapaxar

55 interactions 6 explained in plain English

Also sold as: Zontivity Zontivity®

About Vorapaxar

Vorapaxar is used together with other medications, such as aspirin and clopidogrel (Plavix), to reduce the risk of serious or life-threatening heart or blood vessel problems such as heart attack and stroke in people who have already had a heart attack or have problems with the blood flow in their legs. Vorapaxar is in… Read the full Vorapaxar drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Colchicine Abrocitinib Naproxen Fondaparinux Apixaban

3 Contraindicated 50 Major 2 Moderate

All (55) Contraindicated (3) Major (50) Moderate (2)

Contraindicated

Vorapaxar Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Vorapaxar Abrocitinib Cibinqo Explained Increased risk of bleeding Details Vorapaxar Defibrotide Injection Defitelio Increased risk of bleeding Details

Major

Vorapaxar Abametapir Explained Increased exposure of CYP3A4 substrate Details Vorapaxar Sertraline Explained An increased risk of bleeding Details Vorapaxar Relugolix Orgovyx Explained Increased relugolix exposure Details Vorapaxar Apixaban Eliquis Explained Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Betrixaban Bevyxxa® Increased risk of bleeding Details Vorapaxar Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Vorapaxar Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Vorapaxar Clopidogrel Plavix An increased risk of bleeding Details Vorapaxar Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Vorapaxar Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Vorapaxar Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Vorapaxar Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Vorapaxar Dalteparin Injection Fragmin Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Vorapaxar Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Vorapaxar Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Vorapaxar Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Vorapaxar Digoxin Cardoxin® Increased digoxin exposure Details Vorapaxar Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Vorapaxar Edoxaban Savaysa Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Enoxaparin Lovenox Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Enoxaparin Injection Lovenox Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Etodolac Lodine An increased risk of bleeding Details Vorapaxar Fenoprofen Fenopron An increased risk of bleeding Details Vorapaxar Flurbiprofen Ansaid An increased risk of bleeding Details Vorapaxar Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Vorapaxar Fondaparinux Arixtra Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Fondaparinux Injection Arixtra Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Heparin Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Heparin Injection Lipo-Hepin® Increased risk of bleeding, including intracranial hemorrhage and fatal bleeding Details Vorapaxar Ibrutinib Imbruvica Increased risk of bleeding Details Vorapaxar Ibuprofen Addaprin An increased risk of bleeding Details Vorapaxar Ketoconazole Topical Extina® Foam Increased vorapaxar exposure Details Vorapaxar Ketoprofen Actron® An increased risk of bleeding Details Vorapaxar Ketorolac Acular An increased risk of bleeding Details Vorapaxar Ketorolac Injection Acular An increased risk of bleeding Details Vorapaxar Ketorolac Nasal Spray Sprix An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.