Vorapaxar

Name: Vorapaxar Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

55 interactions 6 explained in plain English

Also sold as: Zontivity Zontivity®

About Vorapaxar

Vorapaxar is used together with other medications, such as aspirin and clopidogrel (Plavix), to reduce the risk of serious or life-threatening heart or blood vessel problems such as heart attack and stroke in people who have already had a heart attack or have problems with the blood flow in their legs. Vorapaxar is in… Read the full Vorapaxar drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Colchicine Abrocitinib Naproxen Fondaparinux Apixaban

3 Contraindicated 50 Major 2 Moderate

All (55) Contraindicated (3) Major (50) Moderate (2)

Moderate

Vorapaxar Icosapent Ethyl Vascepa An increased risk of bleeding Details Vorapaxar Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities or intracerebral hemorrhage Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.