Voxelotor

Major

Voxelotor Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Voxelotor Abametapir Explained Increased exposure of CYP3A4 substrate Details Voxelotor Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Voxelotor Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Voxelotor Abemaciclib Verzenio Explained Increased exposure of sensitive CYP3A4 substrates Details Voxelotor Acalabrutinib Calquence Increased exposure of sensitive CYP3A4 substrates Details Voxelotor Avapritinib Ayvakit Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Voxelotor Cariprazine Vraylar Explained Increased cariprazine and its major active metabolite (didesmethylcariprazine (DDCAR)) exposure Details Voxelotor Amlodipine Amvaz® Increased amLODIPine exposure and an increased risk of hypotension and edema Details Voxelotor Bedaquiline Sirturo Increased bedaquiline exposure Details Voxelotor Bosutinib Bosulif Increased bosutinib exposure Details Voxelotor Brexpiprazole Rexulti Increased brexpiprazole exposure Details Voxelotor Budesonide Entocort Increased budesonide exposure Details Voxelotor Budesonide Nasal Spray Rhinocort Increased budesonide exposure Details Voxelotor Budesonide Oral Inhalation Pulmicort Increased budesonide exposure Details Voxelotor Cobimetinib Cotellic Increased exposure of sensitive CYP3A4 substrates Details Voxelotor Cyclosporine Injection Atopica Increased exposure of sensitive CYP3A4 substrates Details Voxelotor Cyclosporine Ophthalmic Cequa Increased exposure of sensitive CYP3A4 substrates Details Voxelotor Dasatinib Phyrago Increased exposure of sensitive CYP3A4 substrates Details Voxelotor Dihydroergotamine Injection DHE-45® Injection Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Voxelotor Dihydroergotamine Nasal Spray Migranal Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Voxelotor Doxorubicin Adriamycin Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Voxelotor Encorafenib Braftovi Increased encorafenib exposure and an increased risk of encorafenib-related adverse events Details Voxelotor Entrectinib Rozlytrek Increased entrectinib exposure and an increased frequency or severity of adverse reactions Details Voxelotor Everolimus Afinitor Increased exposure of sensitive CYP3A4 substrates Details Voxelotor Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Voxelotor Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Voxelotor Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Voxelotor Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Voxelotor Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Voxelotor Lumateperone Caplyta Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Voxelotor Lurbinectedin Injection Zepzelca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Voxelotor Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of vasospasm, cerebral ischemia and/or ischemia of extremities Details Voxelotor Midostaurin Rydapt Increased exposure of sensitive CYP3A4 substrates Details Voxelotor Mitapivat Aqvesme Increased mitapivat exposure Details Voxelotor Nafcillin Injection Unipen® Injection Decreased voxelotor plasma concentrations and reduced efficacy Details Voxelotor Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Voxelotor Dofetilide Tikosyn Increased dofetilide exposure Details Voxelotor Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Voxelotor Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details