Warfarin

210 interactions 9 explained in plain English
Also sold as: Coumadin Jantoven
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Warfarin Melphalan Alkeran An increased risk of bleeding Details Warfarin Melphalan Injection Alkeran An increased risk of bleeding Details Warfarin Mercaptopurine Purinethol® Reduced anticoagulant effect of warfarin Details Warfarin Methotrexate Jylamvo Increased risk for elevated INR and subsequent bleeding; increased methotrexate exposure, an increased risk of methotrexate-relate... Details Warfarin Methotrexate Injection Abitrexate® Increased risk for elevated INR and subsequent bleeding; increased methotrexate exposure, an increased risk of methotrexate-relate... Details Warfarin Methylphenidate Adhansia XR® Increased coumarin anticoagulants exposure and an increased risk of bleeding Details Warfarin Methylphenidate Transdermal Patch Daytrana Increased coumarin anticoagulants exposure and an increased risk of bleeding Details Warfarin Metronidazole Flagyl Increased warfarin exposure and INR, and an increased risk of bleeding Details Warfarin Metronidazole Injection Flagyl Increased warfarin exposure and INR, and an increased risk of bleeding Details Warfarin Metronidazole Topical MetroCream® Increased warfarin exposure and INR, and an increased risk of bleeding Details Warfarin Metronidazole Vaginal MetroGel® Vaginal Increased warfarin exposure and INR, and an increased risk of bleeding Details Warfarin Mexiletine Mexitil® Increased warfarin exposure and an increased INR Details Warfarin Miconazole Buccal Oravig Increased warfarin exposure, an increased INR and an increased risk of bleeding Details Warfarin Miconazole Topical Aloe Vesta Antifungal Increased warfarin exposure, an increased INR and an increased risk of bleeding Details Warfarin Miconazole Vaginal Lagicam Increased warfarin exposure, an increased INR and an increased risk of bleeding Details Warfarin Miconazole Aloe Vesta Antifungal Increased warfarin exposure, an increased INR and an increased risk of bleeding Details Warfarin Minocycline Amzeeq An increased risk of bleeding Details Warfarin Minocycline Topical Amzeeq An increased risk of bleeding Details Warfarin Mitapivat Aqvesme Reduced CYP3A/CYP2C9 substrate exposure Details Warfarin Montelukast Singulair Reduced warfarin exposure and reduced INR Details Warfarin Moxifloxacin Avelox Increased risk of bleeding Details Warfarin Moxifloxacin Injection Avelox Increased risk of bleeding Details Warfarin Moxifloxacin Ophthalmic Moxeza® Increased risk of bleeding Details Warfarin Nabumetone Relafen An increased risk of bleeding Details Warfarin Nafcillin Injection Unipen® Injection Reduced warfarin exposure, reduced INR/prothrombin time and anticoagulant effectiveness Details Warfarin Naproxen Aleve An increased risk of bleeding Details Warfarin Nevirapine Viramune Altered warfarin exposure and an altered INR Details Warfarin Nintedanib Ofev Increased risk of bleeding Details Warfarin Obeticholic Acid Ocaliva Increased warfarin exposure and an altered (increased or decreased) INR Details Warfarin Ofloxacin Floxin® An increased risk of bleeding Details Warfarin Ofloxacin Ophthalmic Ocuflox An increased risk of bleeding Details Warfarin Ofloxacin Otic Floxin® Otic An increased risk of bleeding Details Warfarin Omadacycline Nuzyra Increased risk of bleeding Details Warfarin Omadacycline Injection Nuzyra Increased risk of bleeding Details Warfarin Oseltamivir Tamiflu Increased risk of bleeding Details Warfarin Oxaliplatin Injection Eloxatin® Increased risk of bleeding Details Warfarin Orlistat Alli An increased risk of bleeding Details Warfarin Oxandrolone Oxandrin Increased warfarin exposure, increased INR, increased anticoagulant response and increased risk of bleeding Details Warfarin Peginterferon Alfa-2A Injection Pegasys Increased warfarin exposure and an increased INR Details Warfarin Penicillin V Potassium Beepen-VK® An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.