Xipamide

49 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bromfenac Ophthalmic Etodolac Naproxen Arsenic Trioxide Hydromorphone Rectal Aspirin

35 Major 14 Moderate

All (49) Major (35) Moderate (14)

Major

Xipamide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Xipamide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Xipamide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Xipamide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Xipamide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Xipamide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Xipamide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Xipamide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Xipamide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Xipamide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Xipamide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Lithium Carbonate Lithobid Lithium toxicity Details Xipamide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Xipamide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Xipamide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

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