Zanubrutinib

Name: Zanubrutinib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

52 interactions 5 explained in plain English

Also sold as: Brukinsa Brukinsa®

About Zanubrutinib

Zanubrutinib is used to treat mantle cell lymphoma (MCL; a fast-growing cancer that begins in the cells of the immune system) in adults who have already been treated with at least one other chemotherapy medication. Zanubrutinib is also used to treat adults with Waldenstrom's macroglobulinemia (WM; a slow-growing cancer… Read the full Zanubrutinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Betrixaban Octreotide Injection Enasidenib Meloxicam Injection Cariprazine

1 Contraindicated 47 Major 4 Moderate

All (52) Contraindicated (1) Major (47) Moderate (4)

Major

Zanubrutinib Meloxicam Injection Alloxate An increased risk of bleeding Details Zanubrutinib Mitapivat Aqvesme Reduced zanubrutinib exposure and reduced efficacy of zanubrutinib Details Zanubrutinib Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Zanubrutinib Nafcillin Injection Unipen® Injection Reduced zanubrutinib exposure and reduced efficacy of zanubrutinib Details Zanubrutinib Nifedipine Adalat® Reduced NIFEdipine exposure Details Zanubrutinib Octreotide Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details Zanubrutinib Octreotide Injection Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.