Zidovudine

21 interactions 1 explained in plain English
Also sold as: Retrovir
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methotrexate Orlistat Dapsone Dapsone Topical Doxorubicin Methotrexate Injection
11 Major 6 Moderate 4 Minor
All (21) Major (11) Moderate (6) Minor (4)

Major

Zidovudine Azathioprine Azasan An increased risk of hepatotoxicity Details Zidovudine Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Zidovudine Dapsone Aczone Hematologic toxicity (neutropenia) Details Zidovudine Dapsone Topical Aczone Hematologic toxicity (neutropenia) Details Zidovudine Doxorubicin Adriamycin Decreased zidovudine efficacy; increased risk of hematologic toxicity Details Zidovudine Flucytosine Hematologic toxicity (neutropenia) Details Zidovudine Hydroxychloroquine Plaquenil An increased risk of seizures Details Zidovudine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Zidovudine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Zidovudine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Zidovudine Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details

Moderate

Zidovudine Acetaminophen And Codeine Capital® & Codeine Explained Neutropenia; acetaminophen toxicity (hepatotoxicity) Details Zidovudine Acetaminophen Acephen Neutropenia; acetaminophen toxicity (hepatotoxicity) Details Zidovudine Acetaminophen Injection Acephen Neutropenia; acetaminophen toxicity (hepatotoxicity) Details Zidovudine Acetaminophen Rectal Acephen Neutropenia; acetaminophen toxicity (hepatotoxicity) Details Zidovudine Interferon Beta-1A Intramuscular Injection Avonex Zidovudine toxicity (lethargy, fatigue, anemia) Details Zidovudine Interferon Beta-1A Subcutaneous Injection Avonex Zidovudine toxicity (lethargy, fatigue, anemia) Details

Minor

Zidovudine Acyclovir Avaclyr Increased lethargy and fatigue Details Zidovudine Acyclovir Injection Avaclyr Increased lethargy and fatigue Details Zidovudine Acyclovir Ophthalmic Avaclyr Increased lethargy and fatigue Details Zidovudine Acyclovir Topical Zovirax Increased lethargy and fatigue Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.