Zopiclone

21 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Hydromorphone Rectal Butorphanol Injection Butorphanol Nasal Spray Midazolam Nasal Spray Cetirizine Ophthalmic
20 Major 1 Moderate
All (21) Major (20) Moderate (1)

Major

Zopiclone Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Zopiclone Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Zopiclone Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Zopiclone Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Zopiclone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Zopiclone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Zopiclone Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Zopiclone Diazepam Rectal Diastat Increased risk of CNS depression Details Zopiclone Esketamine Nasal Spray Spravato Increased risk of sedation Details Zopiclone Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Zopiclone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Zopiclone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Zopiclone Lacosamide Injection Motpoly An increased risk of CNS depression Details Zopiclone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Zopiclone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Zopiclone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Zopiclone Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Zopiclone Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Zopiclone Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Zopiclone Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Zopiclone Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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