Zotepine

63 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Injection Cetirizine Ophthalmic Oxaliplatin Injection Dasatinib Hydroxychloroquine Amisulpride Injection
62 Major 1 Moderate
All (63) Major (62) Moderate (1)

Major

Zotepine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Zotepine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Zotepine Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Zotepine Lacosamide Injection Motpoly An increased risk of CNS depression Details Zotepine Lefamulin Xenleta Increased risk of QT interval prolongation Details Zotepine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Zotepine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Zotepine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Zotepine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Zotepine Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zotepine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Zotepine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Zotepine Metronidazole Flagyl An increased risk of QT interval prolongation Details Zotepine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Zotepine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Zotepine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Zotepine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Zotepine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Zotepine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Zotepine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Zotepine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Zotepine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

Moderate

Zotepine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.