Zotepine

63 interactions 5 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Injection Cetirizine Ophthalmic Oxaliplatin Injection Dasatinib Hydroxychloroquine Amisulpride Injection

62 Major 1 Moderate

All (63) Major (62) Moderate (1)

Major

Zotepine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Zotepine Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zotepine Sertraline Explained An increased risk of QT interval prolongation Details Zotepine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Zotepine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Zotepine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Zotepine Arsenic Trioxide Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Zotepine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Zotepine Arsenic Trioxide Injection Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Zotepine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Zotepine Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Zotepine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Zotepine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Zotepine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Zotepine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Zotepine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Zotepine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Zotepine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zotepine Dasatinib Phyrago An increased risk of QT interval prolongation Details Zotepine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Zotepine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Zotepine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Zotepine Diazepam Rectal Diastat Increased risk of CNS depression Details Zotepine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zotepine Dofetilide Tikosyn An increased risk of QT prolongation and an increased risk of torsades de pointes Details Zotepine Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Zotepine Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Zotepine Encorafenib Braftovi Increased risk of QT interval prolongation Details Zotepine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Zotepine Esketamine Nasal Spray Spravato Increased risk of sedation Details Zotepine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Zotepine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Zotepine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Zotepine Fostemsavir Rukobia Increased risk of torsade de pointes Details Zotepine Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Zotepine Glasdegib Daurismo Increased risk of QT interval prolongation Details Zotepine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Zotepine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Zotepine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Zotepine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.