Zuclopenthixol and Ofloxacin Otic: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Ofloxacin Otic
Zuclopenthixol
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
Avoid the concomitant use of zuclopenthixol and other drugs known to significantly increase the QT interval. Additionally, drugs known to cause electrolyte disturbances (eg, hypokalemia) or drugs known to increase the plasma concentration of zuclopenthixol should be used cautiously. Cases of QT prolongation, ventricular arrhythmias and fibrillation, ventricular tachycardia, torsade de pointes, and sudden death have been reported with zuclopenthixol123.
Why it happens (mechanism)
Additive QT interval prolongation
Literature reports
1 report — tap to read
Common questions
Can I take Zuclopenthixol and Ofloxacin Otic together?
An increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Zuclopenthixol and Ofloxacin Otic interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Zuclopenthixol or Ofloxacin Otic need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: CLOPIXOL-ACUPHASE(R) intramuscular injection, zuclopenthixol acetate intramuscular injection. Lundbeck Canada Inc (per Health Canada), Montreal, QC, Canada, 2014.
- Product Information: Clopixol oral tablets, zuclopenthixol dihydrochloride oral tablets. Lundbeck Limited (per MHRA), 2015.
- Product Information: Clopixol-Acuphase intramuscular injection solution, zuclopenthixol acetate intramuscular injection solution. Lundbeck Limited (per MHRA), Milton Keynes, United Kingdom, 2015.
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Keep reading about Zuclopenthixol
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