Ofloxacin Otic

337 interactions 674 cited references

Also sold as: Floxin® Otic

About Ofloxacin Otic

Ofloxacin otic is used to treat outer ear infections in adults and children, chronic (long-lasting) middle ear infections in adults and children with a perforated eardrum (a condition where the eardrum has a hole in it), and acute (suddenly occurring) middle ear infections in children with ear tubes. Ofloxacin otic is… Read the full Ofloxacin Otic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Levoketoconazole Mesoridazine Pimozide Piperaquine Ziprasidone

12 Contraindicated 240 Major 84 Moderate 1 Minor

All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Contraindicated

Ofloxacin Otic Bepridil An increased risk of QT interval prolongation Details Ofloxacin Otic Cisapride Propulsid® Increased risk of QT interval prolongation Details Ofloxacin Otic Dronedarone Multaq Increased risk of QT interval prolongation Details Ofloxacin Otic Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Ofloxacin Otic Mesoridazine An increased risk of QT interval prolongation Details Ofloxacin Otic Pimozide An increased risk of QT interval prolongation Details Ofloxacin Otic Piperaquine An increased risk of QT interval prolongation Details Ofloxacin Otic Saquinavir An increased risk of QT interval prolongation Details Ofloxacin Otic Sparfloxacin An increased risk of QT interval prolongation Details Ofloxacin Otic Terfenadine An increased risk of QT interval prolongation Details Ofloxacin Otic Thioridazine An increased risk of QT interval prolongation Details Ofloxacin Otic Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Ofloxacin Otic Acarbose Prandase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Otic Acecainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Otic Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Ofloxacin Otic Albiglutide Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Otic Alfuzosin UroXatral An increased risk of QT interval prolongation Details Ofloxacin Otic Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Otic Alosetron Increased plasma concentration and half-life of alosetron Details Ofloxacin Otic Amiodarone Nexterone An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Otic Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Ofloxacin Otic Amitriptyline Elavil An increased risk of QT interval prolongation Details Ofloxacin Otic Amoxapine An increased risk of QT interval prolongation Details Ofloxacin Otic Anagrelide Agrylin Increased anagrelide exposure and increased risk of QT interval prolongation Details Ofloxacin Otic Apomorphine Apokyn An increased risk of QT interval prolongation Details Ofloxacin Otic Aripiprazole Abilify An increased risk of QT interval prolongation Details Ofloxacin Otic Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Ofloxacin Otic Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Ofloxacin Otic Artemether An increased risk of QT interval prolongation Details Ofloxacin Otic Asenapine Saphris Increased risk of QT interval prolongation Details Ofloxacin Otic Astemizole An increased risk of QT interval prolongation Details Ofloxacin Otic Atazanavir Reyataz An increased risk of QT interval prolongation Details Ofloxacin Otic Azimilide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Otic Azithromycin AzaSite An increased risk of QT interval prolongation Details Ofloxacin Otic Bedaquiline Sirturo Increased risk of QT interval prolongation Details Ofloxacin Otic Betamethasone Betavet An increased risk of tendon rupture Details Ofloxacin Otic Bretylium An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Otic Budesonide Entocort An increased risk of tendon rupture Details Ofloxacin Otic Buprenorphine Belbuca An increased risk of QT interval prolongation Details Ofloxacin Otic Bupropion Aplenzin Increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.