Drug Interaction Report

Ofloxacin Otic and Apomorphine: Interaction Details

A pharmacist-reviewed analysis of the Ofloxacin Otic and Apomorphine interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Ofloxacin Otic

Floxin® Otic
+

Apomorphine

Apokyn Kynmobi Onapgo
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 337 documented Ofloxacin Otic interactions, 240 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of QT interval prolongation

Interaction Deep Dive

Use caution when coadministering ofloxacin and other QT prolonging drugs, such as apomorphine, as coadministration may increase the risk of QT interval prolongation due to additive effects on the QT interval. Consider the risks and benefits of apomorphine treatment prior to initiating treatment with apomorphine in patients with risk factors for prolonged QTc23. Because geriatric patients may be particularly sensitive to QT prolongation associated with drug effects, take appropriate precautions when coadministering these drugs to this patient population 1.

Why it happens (mechanism)

Additive QT interval prolongation

Literature reports

1 report — tap to read

a) Although torsades de pointes has not been observed in association with the use of apomorphine at recommended doses in clinical studies, experience is too limited to rule out an increased risk 23.

Common questions

Can I take Ofloxacin Otic and Apomorphine together?

An increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.

How serious is the Ofloxacin Otic and Apomorphine interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Ofloxacin Otic or Apomorphine need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Product Information: FLOXIN(R) oral tablets, ofloxacin oral tablets. Ortho-McNeil, Raritan, NJ, 2011. DailyMed
  2. Product Information: ONAPGO subcutaneous injection, apomorphine HCl subcutaneous injection. MDD US Operations LLC (per FDA), Rockville, MD, 2025. DailyMed
  3. Product Information: APOKYN(R) subcutaneous injection, apomorphine HCl subcutaneous injection. MDD US Operations LLC (per FDA), Rockville, MD, 2025. DailyMed
Was this write-up helpful?
Ofloxacin Otic

Keep reading about Ofloxacin Otic

All Ofloxacin Otic interactions (337) Ofloxacin Otic drug information
Also serious with: Dronedarone Levoketoconazole Mesoridazine Ziprasidone
Apomorphine

Keep reading about Apomorphine

All Apomorphine interactions (73)
Also serious with: Dolasetron Dolasetron Injection Granisetron Transdermal Patch Palonosetron Injection
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Apomorphine + Activated Charcoal St. John's Wort Ayahuasca Bitter Melon Black Horehound Black Pepper Breadfruit Brussels Sprout + 59 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.