Xyosted Generic: When Will Generic Testosterone Enanthate Be Available?
This page is aggregated from FDA records, court filings and company announcements. Coded and designed by Dr. Brian Staiger, PharmD, BCPS
Updated October 9, 2026 How we build our data
Xyosted Generic at a Glance
Four quick answers from FDA records and our estimate.
- When is the first generic expected? September 2036 About 10 years away Why then?
- Has the FDA approved a generic? Unknown No FDA Orange Book record under this name
- When does the brand’s protection end? Unknown Not in the FDA record we could read
- Can you buy a generic today? Not yet No company lists one for sale
Generic testosterone enanthate is expected to be available in September 2036, about 10 years away. None is for sale yet.
Why September 2036?
A patent that protects the brand runs out. After that, approved generics can be sold. We rate it toss-up: still unsettled. Just as likely to slip as to hold.
Will the generic cost less?
Usually, but no company is recorded as having applied to make one yet, and a single company usually brings only a modest drop. See the price pattern
What should I do now?
Keep taking Xyosted as prescribed. When a generic arrives, your pharmacy may switch you to it automatically, and it may look different. What a generic means for you
Our month is only an estimate based on available information, so we never name a day.
Xyosted by the Numbers
- Reason
- Patent expiresA patent that protects the brand runs out. After that, approved generics can be sold.
- How sure
- Toss-up Still unsettled. Just as likely to slip as to hold.
- Price competition
- None filed yet No filers on record
- Brand sales
- $316M a yearBig seller
- Pharmacies pay $316.50 per mL, up 5.8% in a year NADAC, October 2026
- Medicare Part D spent $37.5M in 2025, for 8,199 people CMS Part D Spending by Drug
- Medicaid prescriptions 20.6K in the last four reported quarters, $14.2M CMS Medicaid drug utilization, to Q1 2026
Xyosted’s Road to a Generic
The first generic of Xyosted is expected in September 2036.
Why that month: a patent that protects the brand runs out. After that, approved generics can be sold.
The bar shows Xyosted on the market on its own until the month we expect the first generic (the green band), a month and never a day. Its approval date and patents are not in the FDA Orange Book under this name, so the bar fades in from the left. The expected month comes from court records and company announcements.
Who Is Lined Up to Make Generic Testosterone Enanthate
Three steps stand between a brand and a generic you can buy: a company applies to the FDA, the FDA approves it, and the company starts selling it.
Applied to the FDA
No company is recorded as having applied to the FDA to make a generic Xyosted yet.
Approved by the FDA
We could not find Xyosted’s own record in the FDA Orange Book under this name, so the approved generic makers are not shown.
For Sale in Pharmacies
Not yet. No company lists a generic testosterone enanthate for sale with the FDA.
Sources: how many companies have applied, from court records and company announcements; approved generics from the FDA Orange Book; what is for sale from the FDA NDC Directory. The FDA does not disclose an application before it approves it (21 CFR 314.430).
Xyosted Price: What Pharmacies Pay and What Generics Usually Do
What Pharmacies Pay for Xyosted 100 mg/0.5 mL auto-inj
$316.50 per mL in October 2026, up 5.8% from a year earlier.
Hover over or tap anywhere on the chart to see that month’s price.
- Xyosted 50 mg/0.5 mL auto-inj $316.21 per mL
- Xyosted 75 mg/0.5 mL auto-inj $316.38 per mL
- Xyosted 100 mg/0.5 mL auto-inj $316.50 per mL
See the numbers
| Month | Pharmacies paid per mL |
|---|---|
| October 2026 | $316.50 |
| September 2026 | $316.50 |
| August 2026 | $316.65 |
| July 2026 | $316.91 |
| June 2026 | $317.02 |
| May 2026 | $317.20 |
| April 2026 | $316.92 |
| March 2026 | $316.92 |
| February 2026 | $316.92 |
| January 2026 | $316.92 |
| February 2024 | $299.14 |
| January 2024 | $299.14 |
NADAC: the national average price retail pharmacies pay to buy the medicine (CMS survey, updated weekly), the last price of each month for one package. It is not what you pay: that depends on your insurance or discount card.
What a Generic Could Cost
How we estimate it. We start from what pharmacies pay for Xyosted today: $316.50 per mL for Xyosted 100 mg/0.5 mL auto-inj in October 2026, from the national NADAC survey. Then we apply the FDA’s finding of how far that price usually falls as generic companies join: about 31% with one company, 44% with two, 73% with four and over 95% with six or more (the typical drop for every drug whose first generic came out from 2015 to 2017).
Dollar figures apply FDA’s median drops to the $316.50 pharmacies pay per mL today. An estimate from the pattern, not a price quote: what you pay depends on your insurance or discount card.
Median prices pharmacies paid for the generic (invoice prices), compared with the brand’s price before generic entry, from FDA’s 2019 analysis “Generic Competition and Drug Prices”. At the manufacturer’s price FDA found steeper drops (about 39%, 54%, 79% and over 95%), the figures quoted elsewhere on this tracker. A typical pattern, not a price quote for this medicine.
What Medicare and Medicaid Spend on Xyosted
Big public spending is part of why generic makers line up for a medicine, and why its first generic matters beyond the pharmacy counter. Figures are before manufacturer rebates, which are confidential.
Medicare Part D Spending
What Medicare drug plans spent on Xyosted, before manufacturer rebates.
- $9.5M
- January to March 2026, the latest CMS has posted
For 6,023 people, about $812 per prescription fill - $37.5M
- 2025, the whole year
For 8,199 people, about $793 per prescription fill
See the numbers
| Period | Spending | People | Per fill |
|---|---|---|---|
| January to March 2026 | $9,548,005 | 6,023 | $812.39 |
| 2025 | $37,461,530 | 8,199 | $792.77 |
Source: CMS Medicare Part D Spending by Drug, matched by the brand name Xyosted only, so no generic is counted in it. What CMS says it is used for: This medication is used by men who do not make enough of a natural substance called testosterone (hypogonadism). Testosterone belongs to a class of drugs known as androgens.
Medicaid Prescriptions by Quarter
20,593 prescriptions in the four quarters to Q1 2026, $14.2M paid.
See the numbers
| Quarter | Prescriptions | Medicaid paid |
|---|---|---|
| Q1 2026 | 4,835 | $3,441,843 |
| Q4 2025 | 5,318 | $3,632,607 |
| Q3 2025 | 5,466 | $3,710,093 |
| Q2 2025 | 4,974 | $3,394,073 |
| Q1 2025 | 4,928 | $3,327,094 |
Source: CMS Medicaid State Drug Utilization Data, over Xyosted’s own package codes.
Xyosted NDC Codes and Packages
Each Xyosted package sold today has its own NDC, the product number printed on the box and on the pharmacy label. Open one to see that package’s details, what pharmacies pay for it and its patent timeline.
| NDC | Product | Package | Company |
|---|---|---|---|
| 54436-0200-01 | TESTOSTERONE ENANTHATE 100 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
| 54436-0200-01 | TESTOSTERONE ENANTHATE 100 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
| 54436-0200-04 | TESTOSTERONE ENANTHATE 100 mg/.5mL injection | carton of 4 syringes of .5 mL | Antares Pharma, Inc. |
| 54436-0200-04 | TESTOSTERONE ENANTHATE 100 mg/.5mL injection | carton of 4 syringes of .5 mL | Antares Pharma, Inc. |
| 54436-0200-05 | TESTOSTERONE ENANTHATE 100 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
| 54436-0200-05 | TESTOSTERONE ENANTHATE 100 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
| 54436-0250-01 | TESTOSTERONE ENANTHATE 50 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
| 54436-0250-01 | TESTOSTERONE ENANTHATE 50 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
Show the other 8 Xyosted packages
| NDC | Product | Package | Company |
|---|---|---|---|
| 54436-0250-04 | TESTOSTERONE ENANTHATE 50 mg/.5mL injection | carton of 4 syringes of .5 mL | Antares Pharma, Inc. |
| 54436-0250-04 | TESTOSTERONE ENANTHATE 50 mg/.5mL injection | carton of 4 syringes of .5 mL | Antares Pharma, Inc. |
| 54436-0275-01 | TESTOSTERONE ENANTHATE 75 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
| 54436-0275-01 | TESTOSTERONE ENANTHATE 75 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
| 54436-0275-04 | TESTOSTERONE ENANTHATE 75 mg/.5mL injection | carton of 4 syringes of .5 mL | Antares Pharma, Inc. |
| 54436-0275-04 | TESTOSTERONE ENANTHATE 75 mg/.5mL injection | carton of 4 syringes of .5 mL | Antares Pharma, Inc. |
| 54436-0275-05 | TESTOSTERONE ENANTHATE 75 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
| 54436-0275-05 | TESTOSTERONE ENANTHATE 75 mg/.5mL injection | syringe of .5 mL | Antares Pharma, Inc. |
Source: the FDA NDC Directory, current listings only. Some codes belong to companies that repackage Xyosted: it is the same medicine in a different package.
What a Generic Xyosted Means for You
Nothing Changes Until It Is in Pharmacies
Until a generic is actually for sale, keep filling Xyosted as usual. When one arrives, there is nothing you need to sign up for.
Your Pharmacy May Switch You Automatically
Every state lets pharmacists fill a brand-name prescription with an FDA-approved generic rated as equivalent to it, and about 19 states require them to, unless your prescriber writes “dispense as written” or “brand medically necessary” on the prescription. Some states ask the pharmacist to tell you, or to get your OK first. A study of every state’s law has the details.
It Will Probably Look Different
US trademark law does not let a generic look exactly like the brand, so the color, shape or markings usually change. The active ingredient, strength and form are the same. An “authorized generic,” made by or for the brand’s own company, can look identical. The FDA explains.
Your Insurance May Change Too
Once a lower-cost version is available, many insurance plans charge more for the brand, or stop covering it. Your plan’s drug list (formulary) says how.
Until a generic is on US pharmacy shelves, be careful with websites that offer “generic Xyosted”. The FDA warns that unlicensed online pharmacies sell counterfeit and unapproved medicines; its BeSafeRx page shows how to check a pharmacy.
Questions people ask about Xyosted
Is there a generic for Xyosted right now?
No. As of October 9, 2026 no generic testosterone enanthate is listed for sale in the FDA NDC Directory.
When will Xyosted go generic?
September 2036 is the expected month, and that is toss-up but not certain. A patent that protects the brand runs out. After that, approved generics can be sold.
Will generic testosterone enanthate be the same as Xyosted?
Yes in the ways that matter: the same active ingredient, strength and form, with proof that it reaches your blood the same way. Inactive ingredients can differ, which is why some people notice a different look or taste.
How much will the generic cost?
Nobody can say for sure before launch. No company is recorded as having applied to the FDA to make one yet, and a single company usually brings only a modest drop.
How much does Xyosted cost now?
Pharmacies paid about $316.50 per mL for Xyosted 100 mg/0.5 mL auto-inj in October 2026, by the national survey of what pharmacies pay (NADAC). That is the pharmacy’s cost, not your price: what you pay depends on your insurance or discount card.
Changes to This Projection
- First generic expected September 2036 on this month’s schedule. A line is added here whenever a monthly update moves the month, the reason or how sure it is.
Every change to the expected month is logged here with the month we saw it.
Also Going Generic
- SalonpasMenthol and Methyl SalicylateJanuary 2030
- AlecensaAlectinib Hydrochloride2032 to 2033
- VerquvoVericiguatJanuary 2035
- DocivyxDocetaxelMarch 2036
- NouressCysteine HydrochlorideMarch 2039
- Invega HafyeraPaliperidone PalmitateMay 2041
About Xyosted
- Generic name testosterone enanthate
- How it is taken Injection under the skin
- Hard to copy Inhalers, injectables, patches and other hard-to-copy products. Fewer companies attempt them and dates slip more often.
- More drugs Brand-name drugs starting with X
- Have a question? A pharmacist answers, free. Ask about Xyosted
Sources. The expected month: FDA Paragraph IV Patent Certifications list, federal court records, company announcements and securities filings (settlement dates, launch plans, sales). The record on this page: FDA Orange Book, FDA NDC Directory, NADAC (CMS), CMS Medicare Part D Spending by Drug, Medicaid State Drug Utilization Data, FDA, Generic Competition and Drug Prices (2019). Updated October 9, 2026. Information, not medical advice.