Alpha-alanine - Nexletol (Bempedoic Acid) Interaction
Herbal: Alpha-alanine
Also Known As: 2-aminopropionic Acid, Ala, Alanine Amino Acid, Alpha-Alanine, Alpha-aminopropionic Acid, D-alanine, D-alpha-alanine, DL-alanine, L-alanine, L-alpha-alanine, L-alpha-aminopropionic Acid
Drug: Bempedoic Acid
Brand names:
Nexletol
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
There were no interactions found between Bempedoic Acid and Alpha-alanine. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Alpha-alanine Overview
Alanine, a non-essential amino acid, has two forms: L-alpha-alanine and D-alpha-alanine. L-alpha-alanine is vital in protein synthesis and gluconeogenesis, sourced from diet, amino acid conversion, and glucose metabolism. It stimulates glucagon secretion, raising blood glucose levels in type 1 diabetes without affecting C-peptide or insulin. Conversely, in non-diabetics, it balances glucose levels. Animal studies suggest L-alpha-alanine may improve glutathione levels, enhance electrolyte absorption, reduce ketosis after exertion, and impact glycogen storage disease type II. D-alpha-alanine is explored for neurological effects, acting as an NMDA receptor agonist.
Bempedoic Acid Overview
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Bempedoic acid is used together with lifestyle changes (diet, weight-loss, exercise) and certain cholesterol-lowering medications (HMG-CoA reductase inhibitors [statins]) to further decrease low-density lipoprotein (LDL) cholesterol ('bad cholesterol') in the blood of adults with familial heterozygous hypercholesterolemia (HeFH; an inherited condition in which cholesterol cannot be removed from the body normally) or heart disease. Bempedoic acid is in a class of medications called adenosine triphosphate-citrate lyase (ACL) inhibitors. It works by blocking the production of cholesterol in the liver.
Alpha-alanine - More Interactions
Alpha-alanine interacts with 0 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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