Drug & supplement interaction

Alpine Ragwort + Armodafinil

Armodafinil brand name: Nuvigil.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Alpine Ragwort has a moderate interaction with Armodafinil. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in alpine ragwort.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Alpine Ragwort and Armodafinil

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 3A4 (CYP3A4) INDUCERS

Why this applies to Armodafinil

Armodafinil falls under CYTOCHROME P450 3A4 (CYP3A4) INDUCERS — the group Alpine Ragwort interacts with.

Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in alpine ragwort.
Alpine ragwort contains PAs. PAs are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to understand about this pairing. Armodafinil (Nuvigil) is known to gently speed up a liver enzyme called CYP3A4. Normally that's no big deal, but Alpine Ragwort contains pyrrolizidine alkaloids, and your liver uses that same CYP3A4 enzyme to turn those plant compounds into toxic byproducts. So in theory, taking armodafinil could ramp up that conversion and put extra strain on your liver.

I want to be straight with you, though: this concern comes only from lab-type data, not real patient studies, so it's theoretical. The bigger issue is that Alpine Ragwort itself can seriously harm the liver and isn't recommended for anyone. Please don't change your armodafinil, but do talk with your pharmacist or doctor before going anywhere near this supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  2. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Alpine Ragwort Also Interacts With Other Medications

Alpine Ragwort has 86 moderate known drug interactions in our database — the Armodafinil one above is one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Armodafinil)
Taking anything else?

Check Another of Your Medications Against Alpine Ragwort

Covers the 2,830 medications we’ve checked against Alpine Ragwort. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Armodafinil

This page covers Alpine Ragwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Armodafinil page lists 223 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Jalap (major) and Oleander (major).

By severity: 9 major · 176 moderate · 38 minor.

From our pharmacist’s overview on the Armodafinil page

“Armodafinil (Nuvigil) is a wakefulness drug that works like a stimulant, and the supplements that matter most here do the same thing. Nine of the 223 ingredients on file rate major, and this list warrants real care, starting with those nine.”

Reviewed by 2 · Jul 18, 2026

Open the Armodafinil interaction page

How much people look this up

Where Alpine Ragwort and Armodafinil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpine Ragwort
Steady interest

#1,135 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Armodafinil
Steady interest

#1,673 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Alpine Ragwort

What is Alpine Ragwort?

Alpine Ragwort
  • Traditional wound care
  • Minor bleeding or bruises
  • Digestive complaints
  • Menstrual discomfort
  • Folk remedy for inflammation

Alpine Ragwort is a wild plant in the daisy family that contains pyrrolizidine alkaloids (PAs), which can severely damage the liver. There is no good scientific evidence that it works for any health condition, and the safety risks are serious. We do not recommend using it.

Read the full Alpine Ragwort monograph & all interactions
Medication

About Armodafinil

What Is Armodafinil Used For?

Brand name: Nuvigil

Armodafinil tablets (including the brand Nuvigil) are used to improve wakefulness in adults who have excessive sleepiness linked to one of three conditions: obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD).

In obstructive sleep apnea, armodafinil treats the sleepiness itself — not the underlying airway obstruction. If CPAP (a breathing device worn during sleep) is the right treatment for you, your doctor should try that first before adding armodafinil for sleepiness.

See full Armodafinil drug information
Keep checking

Other Drugs & Alpine Ragwort

Browse every other medication we’ve checked against Alpine Ragwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Alpine Ragwort page.

No interaction 2,743 drugs checked — show the list

We also checked Alpine Ragwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Alpine Ragwort list.

See the full Alpine Ragwort interactions page
See every supplement checked against Armodafinil, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Alpine Ragwort monograph › Uses, safety, and every drug interaction in one place Armodafinil supplement interactions › Every supplement checked against Armodafinil, ranked by severity Armodafinil drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Alpine Ragwort and Armodafinil Together: Common Questions

Can you take Alpine Ragwort with Armodafinil?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Alpine Ragwort and Armodafinil interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Armodafinil and Alpine Ragwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.