American Adder's Tongue + Darolutamide
Darolutamide brand name: Nubeqa.
We found no known interaction between American Adder's Tongue and Darolutamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Darolutamide states a food rule worth keeping to.
American Adder's Tongue and Darolutamide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Darolutamide and American Adder's Tongue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for American Adder's Tongue at all — not against Darolutamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
American Adder's Tongue safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Darolutamide Products Have a Food Rule — American Adder's Tongue Should Not Break It
At least one FDA label for a product containing Darolutamide says to take it with food. If you take American Adder's Tongue on an empty stomach out of habit, keep them separate — and take Darolutamide with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Darolutamide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Take NUBEQA with food.
From the Dosage and Administration section of the FDA label we read for Darolutamide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Darolutamide
This page covers American Adder's Tongue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Darolutamide page lists 144 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 103 moderate · 38 minor.
From our pharmacist’s overview on the Darolutamide page
“Darolutamide (Nubeqa) treats prostate cancer, and supplements deserve real caution alongside it, because most of those listed here can change how much of the drug stays in your blood. Nearly all act on CYP3A4, the liver enzyme that breaks darolutamide down, or on the transport proteins that move it through cells.”
Reviewed by 2 · Jul 18, 2026
Where American Adder's Tongue and Darolutamide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,422 of 1,452 supplements looked up here in the last 7 days
#847 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Adder's Tongue is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Adder's Tongue reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The American Adder's Tongue and Darolutamide records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About American Adder's Tongue
What is American Adder's Tongue?
- Skin ulcers and wounds
- Swollen glands
- Minor skin irritation
- Folk remedy for nausea (as an emetic)
American Adder's Tongue (Erythronium americanum) is a woodland lily used in traditional folk medicine, mainly as a crushed-leaf poultice for skin ulcers and wounds. There is very little modern scientific evidence to support any of its uses, and safety information is limited, so it should be used cautiously and avoided in pregnancy and breastfeeding.
Erythronium americanum · Liliaceae · Leaves and tubers (corms) · Crushed fresh leaves (poultice), juice, tea, tincture
An interaction check asks whether these two react with each other — it does not ask whether American Adder's Tongue is a good idea for someone in your situation. Here is what our American Adder's Tongue record says about it on its own.
American Adder's Tongue: dosing
There is no established or standardized dose for American Adder's Tongue. Because it has not been studied in modern clinical research, no safe and effective amount has been identified.If a product is sold commercially, follow the directions on the label and do not exceed them. Avoid eating raw leaves or corms, as this can cause vomiting.
From our American Adder's Tongue monograph — the full record covers uses, side effects and every documented interaction.
About Darolutamide
What Is Darolutamide Used For?
Brand name: Nubeqa
Nubeqa (darolutamide) tablets are approved for adult men with two forms of advanced prostate cancer. The first is non-metastatic castration-resistant prostate cancer (nmCRPC) — cancer that keeps growing despite hormone-lowering therapy and has not yet spread to other parts of the body. The second is metastatic castration-sensitive prostate cancer (mCSPC) — cancer that has spread but still responds to hormone-lowering treatment.
For mCSPC, Nubeqa can be used alone or in combination with docetaxel (a chemotherapy medicine). In all cases, patients also receive a gonadotropin-releasing hormone (GnRH) agonist or antagonist — a medicine that lowers testosterone — or have already had surgery to remove the testicles.
Most-Reported Side Effects for Darolutamide
From FAERS, the FDA’s public side-effect reporting system (5,501 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & American Adder's Tongue
Browse every other medication we’ve checked against American Adder's Tongue — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked American Adder's Tongue against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Abemaciclib ›
- Escitalopram ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Hydroxyurea ›
- Ibuprofen ›
- Methamphetamine ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Methotrexate ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Isotretinoin ›
- Fluoxetine ›
- Lamotrigine ›
- Azithromycin ›
- Pregabalin ›
- Amlodipine Besylate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Naproxen ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full American Adder's Tongue list.
American Adder's Tongue References
The 2 sources that drive our American Adder's Tongue monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Adder's Tongue is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
- Using Dietary Supplements Wisely — NIH NCCIH Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking American Adder's Tongue and Darolutamide Together: Common Questions
Is it safe to take American Adder's Tongue with Darolutamide?
Should I take American Adder's Tongue and Darolutamide at the same time of day?
Does Darolutamide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.