Drug & supplement interaction

Andrachne + Doravirine

Doravirine brand name: Pifeltro.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Andrachne and Doravirine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Andrachne and Doravirine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doravirine and Andrachne in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Andrachne at all — not against Doravirine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Andrachne safety at a glance

Andrachne overall Not established There is very little reliable safety data on Andrachne in humans.
Pregnancy Avoid Safety is unknown, so it is best to avoid use during pregnancy.
Breastfeeding Avoid There is no safety data during breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doravirine and Andrachne? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Doravirine’s Own FDA Label Lists

This is not an interaction — none of it involves Andrachne. These are the most notable effects listed in the ADVERSE REACTIONS section of Doravirine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on
  • Vivid dreams or nightmares
  • Stomach upset
  • Stomach pain
  • Tiredness
  • Dizziness
  • Diarrhea
  • A skin rash
  • Headache
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Doravirine. Read the label on DailyMed › Andrachne’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Andrachne side to compare — that is a limit of the record, not a statement that Andrachne has no side effects.

Everything else you take

See Every Supplement That Interacts With Doravirine

This page covers Andrachne only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doravirine page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Doravirine page

“Doravirine (Pifeltro) is an HIV medicine, and keeping its blood level steady is what keeps the virus suppressed, so this list of 138 interacting supplements deserves real vigilance. Three entries are rated major, and St.”

Reviewed by 2 · Jul 18, 2026

Open the Doravirine interaction page

How much people look this up

Where Andrachne and Doravirine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andrachne
Steady interest

#1,248 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doravirine
Steady interest

#1,560 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Andrachne is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andrachne reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Andrachne and Doravirine records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Andrachne

What is Andrachne?

Andrachne
  • Fever
  • Diarrhea
  • Urinary tract complaints
  • Antimicrobial support
  • Antioxidant support

Andrachne is a group of flowering plants used in some traditional medicine systems for fever, diarrhea, and urinary problems, but there is very little human research to support these uses. Because its safety has not been well studied, it is best to be cautious and talk with a pharmacist or doctor before trying it.

Phyllanthaceae · Leaves, stems, and roots · Traditional teas, decoctions, and crude plant extracts

An interaction check asks whether these two react with each other — it does not ask whether Andrachne is a good idea for someone in your situation. Here is what our Andrachne record says about it on its own.

Andrachne: dosing

There is no established or standardized dose for Andrachne. Because it has not been well studied, experts cannot recommend a safe and effective amount.If you are considering a product that contains Andrachne, follow the directions on the label and do not exceed them.

From our Andrachne monograph — the full record covers uses, side effects and every documented interaction.

Read the full Andrachne monograph & all interactions
Medication

About Doravirine

What Is Doravirine Used For?

Brand name: Pifeltro

Pifeltro (doravirine) is used to treat HIV-1 infection in adults and in children and adolescents who weigh at least 35 kg (about 77 lbs). It is always used in combination with other antiretroviral medicines — never on its own.

Pifeltro is approved for two groups: people who have never taken HIV treatment before, and people who are already virologically suppressed (meaning HIV is undetectable in their blood) on a stable regimen and need to switch, provided they have no history of treatment failure or known resistance to doravirine.

See full Doravirine drug information
Keep checking

Other Drugs & Andrachne

Browse every other medication we’ve checked against Andrachne — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Andrachne against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Andrachne list.

See the full Andrachne interactions page
See every supplement checked against Doravirine, ranked by severity
Evidence & sources

Andrachne References

The 3 sources that drive our Andrachne monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Andrachne is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Phyllanthaceae and related medicinal plants — MedlinePlus Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Andrachne and Doravirine Together: Common Questions

Is it safe to take Andrachne with Doravirine?
We do not list a known interaction between Andrachne and Doravirine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Doravirine interact with any supplements?
Yes. Doravirine has documented interactions with 138 supplements in our database — Andrachne is not one of them. The Doravirine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Andrachne monograph Uses, safety profile, and every drug interaction in one place Doravirine drug information The full plain-English guide to this medication Doravirine supplement interactions Every supplement checked against Doravirine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doravirine and Andrachne?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.