Andrachne - Provigil (Modafinil) Interaction
Herbal: Andrachne
Also Known As: Jerusalem oak
Drug: Modafinil
Brand names:
Provigil, Sparlon, Alertec
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Modafinil and Andrachne. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Andrachne Overview
Andrachne, a genus of flowering plants within the Phyllanthaceae family, comprises approximately 30 species found in Africa, Asia, and Europe. These plants are characterized by their small, inconspicuous flowers and simple leaves. Some species, such as Andrachne telephioides, have been used in traditional medicine for treating fever, diarrhea, and urinary tract infections.
The leaves and stems of Andrachne telephioides contain various bioactive compounds, including flavonoids, phenolic acids, and tannins. These compounds are recognized for their antioxidant properties, which can safeguard cells against oxidative damage caused by free radicals.
Traditionally, Andrachne telephioides has been employed to address fever, diarrhea, and urinary tract infections. These applications indicate potential antimicrobial and antipyretic properties, although further research is necessary to validate these effects and comprehend their mechanisms.
Andrachne aspera has been investigated for its medicinal effects, and its root extract may be effective in eliminating harmful bacteria such as S. epidermidis.
Modafinil Overview
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Modafinil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts). Modafinil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn't get enough restful sleep). Modafinil is in a class of medications called wakefulness promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.
Andrachne - More Interactions
Andrachne interacts with 0 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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