Andrachne + Varenicline
Varenicline brand names: Chantix, Champix, Tyrvaya.
We found no known interaction between Andrachne and Varenicline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Varenicline states a food rule worth keeping to.
Andrachne and Varenicline
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Varenicline and Andrachne in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Andrachne at all — not against Varenicline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Andrachne safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Varenicline Products Have a Food Rule — Andrachne Should Not Break It
At least one FDA label for a product containing Varenicline says to take it with food. If you take Andrachne on an empty stomach out of habit, keep them separate — and take Varenicline with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Varenicline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Varenicline tablets should be taken orally after eating and with a full glass of water.
From the Dosage and Administration section of the FDA label we read for Varenicline — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Varenicline
This page covers Andrachne only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Varenicline page lists 20 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (moderate), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).
By severity: 1 major · 10 moderate · 9 minor.
From our pharmacist’s overview on the Varenicline page
“For anyone taking varenicline (Chantix, Champix, Tyrvaya) to quit smoking, this list earns real caution rather than a quick skim. Activated charcoal is the single entry rated major; it binds many medicines in the gut and can pull varenicline's blood levels down, and losing that support mid-quit is a genuine setback.”
Reviewed by 2 · Jul 18, 2026
Where Andrachne and Varenicline Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#706 of 1,452 supplements looked up here in the last 7 days
#674 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Andrachne is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andrachne reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Andrachne and Varenicline records this page draws on were last updated June 20, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Andrachne
What is Andrachne?
- Fever
- Diarrhea
- Urinary tract complaints
- Antimicrobial support
- Antioxidant support
Andrachne is a group of flowering plants used in some traditional medicine systems for fever, diarrhea, and urinary problems, but there is very little human research to support these uses. Because its safety has not been well studied, it is best to be cautious and talk with a pharmacist or doctor before trying it.
Phyllanthaceae · Leaves, stems, and roots · Traditional teas, decoctions, and crude plant extracts
An interaction check asks whether these two react with each other — it does not ask whether Andrachne is a good idea for someone in your situation. Here is what our Andrachne record says about it on its own.
Andrachne: dosing
There is no established or standardized dose for Andrachne. Because it has not been well studied, experts cannot recommend a safe and effective amount.If you are considering a product that contains Andrachne, follow the directions on the label and do not exceed them.
From our Andrachne monograph — the full record covers uses, side effects and every documented interaction.
About Varenicline
What Is Varenicline Used For?
Brand names: Chantix, Champix, Tyrvaya
Varenicline tablets — sold under brand names including Chantix — are used to help adults quit smoking. They work as part of a structured smoking cessation program.
Tyrvaya (varenicline solution) nasal spray is a separate product used to treat the signs and symptoms of dry eye disease. It is not used for smoking cessation.
Most-Reported Side Effects for Varenicline
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Andrachne
Browse every other medication we’ve checked against Andrachne — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Andrachne against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Ivermectin ›
- Testosterone ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Escitalopram ›
- Rivaroxaban ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Methamphetamine ›
- Tirzepatide ›
- Tadalafil ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Amitriptyline ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Isotretinoin ›
- Lisinopril ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Amphetamine ›
- Bupropion ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Codeine ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Methylene Blue ›
- Citalopram ›
- Buspirone ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Andrachne list.
Andrachne References
The 3 sources that drive our Andrachne monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Andrachne is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Phyllanthaceae and related medicinal plants — MedlinePlus Source
- Using Dietary Supplements Wisely — NIH NCCIH Source
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Andrachne and Varenicline Together: Common Questions
Is it safe to take Andrachne with Varenicline?
Should I take Andrachne and Varenicline at the same time of day?
Does Varenicline interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Varenicline and Andrachne?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.