Drug & supplement interaction

Antioxidants + Regorafenib

Regorafenib brand name: Stivarga.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Antioxidants and Regorafenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Antioxidants and Regorafenib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Regorafenib and Antioxidants in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Antioxidants at all — not against Regorafenib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Antioxidants safety at a glance

Antioxidants overall Use caution Antioxidants from food are very safe, but high-dose supplements may carry risks for some people.
Pregnancy Possibly Safe When certain antioxidants are used orally and appropriately during pregnancy. See monographs of specific ingredients for more information. Read the full pregnancy detail
Breastfeeding Use caution Dietary amounts are fine, but check with your doctor before taking high-dose supplements.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Regorafenib and Antioxidants? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Regorafenib’s Own FDA Label Lists

This is not an interaction — none of it involves Antioxidants. These are the most notable effects listed in the ADVERSE REACTIONS section of Regorafenib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Tiredness mentioned in 23.6% of FDA reports for Regorafenib
  • Reduced appetite mentioned in 9.5% of FDA reports for Regorafenib
  • Weight loss
  • Diarrhea mentioned in 12.3% of FDA reports for Regorafenib
  • Fever
  • Stomach pain

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Regorafenib. Read the label on DailyMed › Where a percentage is shown, it is the share of 11,442 voluntary FDA FAERS reports for Regorafenib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Antioxidants’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Antioxidants side to compare — that is a limit of the record, not a statement that Antioxidants has no side effects.

Special populations

Antioxidants in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When certain antioxidants are used orally and appropriately during pregnancy. See monographs of specific ingredients for more information.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Regorafenib Is Prescribed For, and What Antioxidants Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Regorafenib is a prescription medicine with approved uses on its FDA label. Antioxidants is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Regorafenib is prescribed for: Stivarga is approved to treat three types of advanced cancer in adults. It is used for metastatic colorectal cancer (cancer that has spread) after prior chemotherapy and targeted therapy; for locally advanced, unresectable, or metastatic gastrointestinal stromal tumor (GIST) after two previous treatments; and for hepatocellular carcinoma (liver cancer) after treatment with sorafenib. All three uses are specific to Stivarga tablets taken by mouth. It is intended for patients whose cancer has progressed despite earlier lines of therapy.

Antioxidants has been studied for:

  • Colorectal cancer studied, not established Antioxidants has been studied for this. Natural Medicines rates the evidence: Possibly Ineffective Read what the research shows

    Antioxidants for colorectal cancer

    Long-term use of the antioxidants selenium or vitamin E does not appear to prevent colorectal cancer.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Regorafenib on your own; if you are taking Antioxidants for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Regorafenib

This page covers Antioxidants only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Regorafenib page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Regorafenib page

“Regorafenib (Stivarga) is a targeted oral cancer therapy, and with a drug like this the goal is keeping its blood level inside a fairly tight window, so the 138 supplements and herbs on this page deserve real respect. Nearly all of them, 121 in total, can shift how the liver enzyme CYP3A4 processes the drug, nudging its level up or down.”

Reviewed by 2 · Jul 18, 2026

Open the Regorafenib interaction page

How much people look this up

Where Antioxidants and Regorafenib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Antioxidants
Steady interest

#1,226 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Regorafenib
Top half

#1,041 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Antioxidants reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Antioxidants and Regorafenib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Antioxidants

What is Antioxidants?

  • General wellness and aging
  • Heart health support
  • Eye health
  • Immune support
  • Skin health

Antioxidants are compounds—like vitamins C and E, selenium, and many plant chemicals—that help protect your cells from a type of damage called oxidative stress. Getting them from a varied diet of fruits and vegetables is clearly healthy, but high-dose antioxidant supplements have shown disappointing or even harmful results in some large studies. For most people, food is the safest and best source.

Capsules, tablets, softgels, powders, and foods (fruits, vegetables, nuts)

An interaction check asks whether these two react with each other — it does not ask whether Antioxidants is a good idea for someone in your situation. Here is what our Antioxidants record says about it on its own.

Antioxidants: dosing

There is no single "antioxidant dose" because the term covers many different nutrients and plant compounds. For vitamins and minerals, established recommended daily amounts and upper limits exist (set by health authorities), and exceeding the upper limit can be unsafe.The best general approach is to get antioxidants from a varied diet rather than pills.

From our Antioxidants monograph — the full record covers uses, side effects and every documented interaction.

Read the full Antioxidants monograph & all interactions
Medication

About Regorafenib

What Is Regorafenib Used For?

Brand name: Stivarga

Stivarga is approved to treat three types of advanced cancer in adults. It is used for metastatic colorectal cancer (cancer that has spread) after prior chemotherapy and targeted therapy; for locally advanced, unresectable, or metastatic gastrointestinal stromal tumor (GIST) after two previous treatments; and for hepatocellular carcinoma (liver cancer) after treatment with sorafenib.

All three uses are specific to Stivarga tablets taken by mouth. It is intended for patients whose cancer has progressed despite earlier lines of therapy.

Most-Reported Side Effects for Regorafenib

From FAERS, the FDA’s public side-effect reporting system (11,542 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,769 reports
Palmar-plantar erythrodysaesthesia syndrome 1,439 reports
Diarrhea 1,418 reports
Decreased appetite 1,091 reports
Asthenia 946 reports
See full Regorafenib drug information
Keep checking

Other Drugs & Antioxidants

Browse every other medication we’ve checked against Antioxidants — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Antioxidants against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Antioxidants list.

See the full Antioxidants interactions page
See every supplement checked against Regorafenib, ranked by severity
Evidence & sources

Antioxidants References

The 1 references that drive our Antioxidants monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tenório MB, Ferreira RC, Moura FA, Bueno NB, Goulart MOF, Oliveira ACM. Oral antioxidant therapy for prevention and treatment of preeclampsia: Meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2018 Sep;28(9):865-876. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Antioxidants and Regorafenib Together: Common Questions

Is it safe to take Antioxidants with Regorafenib?
We do not list a known interaction between Antioxidants and Regorafenib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Antioxidants and Regorafenib used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Antioxidants in each. That is a conversation for your prescriber, especially if Regorafenib is being adjusted to a target.
Does Regorafenib interact with any supplements?
Yes. Regorafenib has documented interactions with 138 supplements in our database — Antioxidants is not one of them. The Regorafenib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Antioxidants monograph Uses, safety profile, and every drug interaction in one place Regorafenib drug information The full plain-English guide to this medication Regorafenib supplement interactions Every supplement checked against Regorafenib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Regorafenib and Antioxidants?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.