Avocado + Sodium Oxybate
Sodium Oxybate brand name: Xyrem.
We found no known interaction between Avocado and Sodium Oxybate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium Oxybate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Avocado and Sodium Oxybate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sodium Oxybate and Avocado in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Avocado safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Sodium Oxybate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium Oxybate is filed under 3 classifications — sodium-containing drugs, seizure threshold lowering drugs, oral drugs. Avocado has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Sodium Oxybate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Avocado Does Interact With Other Medications
Avocado has 2 moderate known drug interactions in our database — Sodium Oxybate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Avocado
We haven’t checked that one against Avocado yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Avocado. Pick one to open its full report.
Some Sodium Oxybate Products Have a Food Rule — Avocado Should Not Break It
At least one FDA label for a product containing Sodium Oxybate says to take it with food. If you take Avocado on an empty stomach out of habit, keep them separate — and take Sodium Oxybate with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium Oxybate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
• Allow 2 hours after eating before dosing ( 2.3 ).
From the Dosage and Administration section of the FDA label we read for Sodium Oxybate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Avocado or Sodium Oxybate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Avocado or Sodium Oxybate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Sodium Oxybate
This page covers Avocado only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Oxybate page lists 25 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).
By severity: 1 major · 15 moderate · 9 minor.
From our pharmacist’s overview on the Sodium Oxybate page
“Activated charcoal is the single major-rated interaction with sodium oxybate (Xyrem), and it earns that rating because the drug only works if each dose is fully absorbed; charcoal can bind it in the gut and weaken the nighttime control it provides for narcolepsy. Treat this list with genuine care, since 17 of the 25 ingredients on file…”
Reviewed by 2 · Jul 18, 2026
Taking Avocado as Part of a Dietary Supplement Product? Check It for Interactions
We hold 68 real supplement products containing Avocado, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Avocado. Even though Avocado itself has no known interaction with Sodium Oxybate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Avocado and Sodium Oxybate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#599 of 1,452 supplements looked up here in the last 7 days
#672 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Avocado reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Avocado and Sodium Oxybate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Avocado
What is Avocado?
- Heart and cholesterol health
- Osteoarthritis (as ASU)
- General nutrition and healthy fats
- Skin and hair care
- Blood sugar support
Avocado is a nutritious fruit rich in healthy monounsaturated fats, fiber, and potassium, and eating it as part of a balanced diet may support heart health. A specific extract called avocado/soybean unsaponifiables (ASU) has been studied for osteoarthritis, but evidence is mixed. As a food it is very safe for most people; talk to your pharmacist or doctor before using concentrated supplements.
Persea americana · Lauraceae · Fruit pulp, oil, seed, and leaves · Whole fruit, avocado oil, capsules (avocado/soybean unsaponifiables or ASU), powders
An interaction check asks whether these two react with each other — it does not ask whether Avocado is a good idea for someone in your situation. Here is what our Avocado record says about it on its own.
Avocado: dosing
There is no official standardized dose of avocado, since it is mainly eaten as a food. A common serving is part of a whole fruit, eaten as part of a balanced diet.For supplements such as ASU, the right amount depends on the specific product, so it is best to follow the directions on the label.
From our Avocado monograph — the full record covers uses, side effects and every documented interaction.
About Sodium Oxybate
What Is Sodium Oxybate Used For?
Brand name: Xyrem
Sodium oxybate treats two major symptoms of narcolepsy: cataplexy (sudden muscle weakness triggered by emotion) and excessive daytime sleepiness (EDS). It is available in several products, each approved for these uses.
Xyrem (oral solution) and the generic sodium oxybate oral solution are approved for cataplexy or EDS in patients with narcolepsy. Lumryz (extended-release oral suspension) is specifically approved for cataplexy or EDS in patients 7 years of age and older with narcolepsy. The generic sodium oxybate oral solution label does not include the pediatric indication due to marketing exclusivity held by Xyrem.
Most-Reported Side Effects for Sodium Oxybate
From FAERS, the FDA’s public side-effect reporting system (65,536 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Avocado
Browse every other medication we’ve checked against Avocado — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Avocado against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Avocado list.
Avocado References
The 10 references that drive our Avocado monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blickstein D, Shaklai M, Inbal A. Warfarin antagonism by avocado. Lancet 1991;337:914-5. PubMed
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
- Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
- Stucker M, Memmel U, Hoffmann M, et al. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. Dermatology 2001;203:141-7.
- Ahlroth, M., Alenius, H., Turjanmaa, K., Makinen-Kiljunen, S., Reunala, T., and Palosuo, T. Cross-reacting allergens in natural rubber latex and avocado. J.Allergy Clin.Immunol. 1995;96(2):167-173. PubMed
- de Groot, A. C., van der Meeren, H. L., and Weyland, J. W. Contact allergy to avocado oil in a sunscreen. Contact Dermatitis 1987;16(2):108-109. PubMed
- Blanco, C., Carrillo, T., Castillo, R., Quiralte, J., and Cuevas, M. Avocado hypersensitivity. Allergy 1994;49(6):454-459. PubMed
- Crisi, G. and Belsito, D. V. Contact urticaria from latex in a patient with immediate hypersensitivity to banana, avocado and peach. Contact Dermatitis 1993;28(4):247-248.
- Cherian S, Neupert K, Varshney P. Avocado as an emerging trigger for food protein-induced enterocolitis syndrome. Ann Allergy Asthma Immunol. 2018;121(3):369-71. PubMed
- Lichtenstein AH, Kris-Etherton PM, Petersen KS, et al. Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial. J Am Heart Assoc 2022;11(14):e025657.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Avocado and Sodium Oxybate Together: Common Questions
Is it safe to take Avocado with Sodium Oxybate?
Do Avocado and Sodium Oxybate have any of the same side effects?
Should I take Avocado and Sodium Oxybate at the same time of day?
How was the Avocado and Sodium Oxybate combination checked?
Does Avocado interact with any other medications?
Does Sodium Oxybate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.