Drug & supplement interaction

Bear's Garlic + Tezacaftor, Ivacaftor

Tezacaftor, Ivacaftor brand name: Symdeko.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Bear's Garlic and Tezacaftor, Ivacaftor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bear's Garlic and Tezacaftor, Ivacaftor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tezacaftor, Ivacaftor and Bear's Garlic in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bear's Garlic safety at a glance

Bear's Garlic overall Use caution Generally safe as a food, but supplement-level safety is not well studied.

Pregnancy Use caution Food amounts are likely fine, but avoid concentrated supplements due to lack of safety data.

Breastfeeding Use caution Food amounts are likely fine, but supplement safety is unknown, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tezacaftor, Ivacaftor and Bear's Garlic? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Tezacaftor, Ivacaftor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tezacaftor, Ivacaftor is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Bear's Garlic has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Tezacaftor, Ivacaftor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bear's Garlic Does Interact With Other Medications

Bear's Garlic has 122 moderate known drug interactions in our database — Tezacaftor, Ivacaftor isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Tezacaftor, Ivacaftor)

Taking anything else?

Check Another of Your Medications Against Bear's Garlic

Covers the 2,830 medications we’ve checked against Bear's Garlic. Pick one to open its full report.

What to actually watch for

What Tezacaftor, Ivacaftor’s Own FDA Label Lists

This is not an interaction — none of it involves Bear's Garlic. These are the most notable effects listed in the ADVERSE REACTIONS section of Tezacaftor, Ivacaftor’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

Thoughts of self-harm Worth acting on
A bowel blockage Worth acting on
Low mood Worth acting on
Raised blood pressure Worth acting on
A severe allergic reaction Worth acting on
A higher chance of infection Worth acting on
An allergic reaction Worth acting on
A stuffy or runny nose
Anxiety or restlessness
Trouble sleeping

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Tezacaftor, Ivacaftor. Read the label on DailyMed › Bear's Garlic’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Bear's Garlic side to compare — that is a limit of the record, not a statement that Bear's Garlic has no side effects.

Everything else you take

See Every Supplement That Interacts With Tezacaftor, Ivacaftor

This page covers Bear's Garlic only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tezacaftor, Ivacaftor page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Tezacaftor, Ivacaftor page

“Symdeko (tezacaftor and ivacaftor) treats cystic fibrosis and depends on a steady blood level, which is exactly what most of this list can upset, so it deserves genuine attention. The great majority of these ingredients act on CYP3A4, the liver enzyme that clears the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Tezacaftor, Ivacaftor interaction page

How much people look this up

Where Bear's Garlic and Tezacaftor, Ivacaftor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bear's Garlic

Steady interest

#817 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Tezacaftor, Ivacaftor

Top 10%

#162 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bear's Garlic reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Bear's Garlic and Tezacaftor, Ivacaftor records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Bear's Garlic

What is Bear's Garlic?

Seasoning and culinary flavoring
Heart and blood vessel health
Blood pressure support
Digestive complaints
General 'cleansing' or detox traditions

Bear's garlic is a wild relative of garlic enjoyed mainly as a mild-tasting food. Some early laboratory studies hint at heart and blood vessel benefits, but solid human evidence is lacking, so it should be viewed as a flavorful food rather than a proven remedy. As food it is generally well tolerated, but supplements or large amounts have not been well studied for safety.

Allium ursinum · Amaryllidaceae · Leaves and bulb · Fresh leaves, dried herb, tinctures, capsules, juice, teas, culinary pesto

An interaction check asks whether these two react with each other — it does not ask whether Bear's Garlic is a good idea for someone in your situation. Here is what our Bear's Garlic record says about it on its own.

Bear's Garlic: dosing

There is no established standardized dose for bear's garlic. As a food, people use the fresh leaves in cooking to taste during its spring season.For supplement forms such as capsules or tinctures, there is no proven medicinal dose.

From our Bear's Garlic monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bear's Garlic monograph & all interactions

Medication

About Tezacaftor and Ivacaftor

What Is Tezacaftor and Ivacaftor Used For?

Brand name: Symdeko

Tezacaftor and ivacaftor (Symdeko) treats cystic fibrosis (CF) in people aged 6 years and older. It is for people who have two copies of the F508del mutation. It is also for people who have at least one other CFTR gene mutation that responds to this medicine.

If your genetic type is unknown, an FDA-cleared CF mutation test is used to check for a CFTR mutation.

See full Tezacaftor and Ivacaftor drug information

Keep checking

Other Drugs & Bear's Garlic

Browse every other medication we’ve checked against Bear's Garlic — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

122Moderate

0Minor

2,707No known interaction

122 Moderate 2,707 No interaction

Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Bear's Garlic page.

No interaction 2,707 drugs checked — show the list

We also checked Bear's Garlic against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Bear's Garlic list.

See the full Bear's Garlic interactions page

See every supplement checked against Tezacaftor, Ivacaftor, ranked by severity

Evidence & sources

Bear's Garlic References

The 3 references that drive our Bear's Garlic monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Carotenuto A, De Feo V, Fattorusso E, et al. The flavonoids of Allium ursinum. Phytochem 1996;41:531-6. PubMed
Bobak M, Skodova Z, Marmot M. Beer and obesity: a cross-sectional study. Eur J Clin Nutr 2003;57:1250-53. PubMed
Koh-Banerjee P, Chu N, Spiegelman D, et al. Prospective study of the association of changes in dietary intake, physicial activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. Am J Clin Nutr 2003;78:719-27..

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bear's Garlic and Tezacaftor, Ivacaftor Together: Common Questions

Is it safe to take Bear's Garlic with Tezacaftor, Ivacaftor?

We do not list a known interaction between Bear's Garlic and Tezacaftor, Ivacaftor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Bear's Garlic and Tezacaftor, Ivacaftor combination checked?

Interactions in our licensed database are recorded against drug classes. Tezacaftor, Ivacaftor is filed under 2 classifications, and Bear's Garlic has documented interactions with 1 drug class — none of Tezacaftor, Ivacaftor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Bear's Garlic interact with any other medications?

Yes. Bear's Garlic has 122 documented drug interactions in our database — Tezacaftor, Ivacaftor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Tezacaftor, Ivacaftor interact with any supplements?

Yes. Tezacaftor, Ivacaftor has documented interactions with 138 supplements in our database — Bear's Garlic is not one of them. The Tezacaftor, Ivacaftor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bear's Garlic monograph Uses, safety profile, and every drug interaction in one place Tezacaftor and Ivacaftor drug information The full plain-English guide to this medication Tezacaftor, Ivacaftor supplement interactions Every supplement checked against Tezacaftor, Ivacaftor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tezacaftor, Ivacaftor and Bear's Garlic?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.