Drug & supplement interaction

Beta-sitosterol + Tolazamide

Tolazamide brand name: Tolinase.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Beta-sitosterol and Tolazamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Beta-sitosterol and Tolazamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tolazamide and Beta-sitosterol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Beta-sitosterol at all — not against Tolazamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Beta-sitosterol safety at a glance

Beta-sitosterol overall Use caution Generally well tolerated for most adults when used short-term, but check with a healthcare provider first.
Pregnancy Avoid There is not enough safety data, so it is best to avoid supplemental use during pregnancy.
Breastfeeding Avoid There is not enough safety data, so it is best to avoid supplemental use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tolazamide and Beta-sitosterol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Beta-sitosterol Itself Has Been Linked To

This is not an interaction — nothing below involves Tolazamide. It is the side-effect record for Beta-sitosterol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Beta-sitosterol, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Pancreatitis Worth acting on Additional detail

    “Orally, beta-sitosterol can cause nausea, indigestion, gas, diarrhea, or constipation. Beta-sitosterol can also reduce the appetite. There is a case report of acute pancreatitis thought to be associated with taking beta-sitosterol in a 57-year-old male.”

    Beta-sitosterol · Natural Medicines adverse-effect record, reported in constipation.

    5 sources cited
    1. 5327. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
    2. 5328. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
    3. 5334. Becker M, Staab D, Von Bergman K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 1992;89:138-42. DOI
    4. 106080. Lorenze A, Hsueh W, Nasr J. Beta-sitosterol-induced acute pancreatitis: A case report and review of the literature. Cureus. 2020;12(3):e7407. PubMed
    5. 15550. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  • A change in sex drive / Erection problems Additional detail

    “Orally, beta-sitosterol can cause erectile dysfunction and loss of libido.”

    Beta-sitosterol · Natural Medicines adverse-effect record, reported in erectile dysfunction (ed).

    2 sources cited
    1. 5327. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
    2. 5329. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 1999;83:976-83. PubMed
  • Acne Additional detail

    “Orally, beta-sitosterol can worsen acne when taken alone or in combination with saw palmetto.”

    Beta-sitosterol · Natural Medicines adverse-effect record, reported in acne.

    2 sources cited
    1. 5331. Oster P, Schlierf G, Heuck CC, et al. [Sitosterol in familial hyperlipoproteinemia type II. A randomized, double-blind, cross-over study]. Dtsch Med Wochenschr 1976;101:1308-11.
    2. 15550. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  • Bloating or gas / Reduced appetite Additional detail

    Recorded for Beta-sitosterol in the same Natural Medicines adverse-effect record shown under Pancreatitis above.

  • Stomach upset / Constipation / Diarrhea / Nausea Additional detail

    “Orally, beta-sitosterol is generally well tolerated. Topically, beta-sitosterol seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Constipation, diarrhea, gas, indigestion, and nausea.”

    Beta-sitosterol · Natural Medicines adverse-effect record, reported in constipation.

Everything above comes from the Natural Medicines adverse-effect record for Beta-sitosterol — expand a row for the licensed statement it rests on. We haven’t matched Tolazamide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Tolazamide.

Everything else you take

See Every Supplement That Interacts With Tolazamide

This page covers Beta-sitosterol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolazamide page lists 272 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 230 moderate · 40 minor.

From our pharmacist’s overview on the Tolazamide page

“Tolazamide (Tolinase) lowers blood sugar in type 2 diabetes, and I would handle its supplement list with care, because nearly everything listed can drag blood sugar lower still. Herbs and foods with glucose-lowering effects dominate the file, and stacked on a pill that already lowers glucose they raise the odds of hypoglycemia, blood s…”

Reviewed by 2 · Jul 18, 2026

Open the Tolazamide interaction page

One more smart check

Taking Beta-sitosterol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Beta-sitosterol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beta-sitosterol. Even though Beta-sitosterol itself has no known interaction with Tolazamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Beta-sitosterol and Tolazamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beta-sitosterol
Top 25%

#320 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolazamide
Top half

#1,107 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beta-sitosterol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Beta-sitosterol and Tolazamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Beta-sitosterol

What is Beta-sitosterol?

  • High cholesterol
  • Enlarged prostate (BPH)
  • Heart health
  • Immune support
  • Hair loss

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker for others, and it is generally well tolerated, but you should talk with your pharmacist or doctor before starting it.

Plant sterol found in seeds, nuts, vegetable oils, and many plants · Capsules, tablets, softgels, and fortified foods

An interaction check asks whether these two react with each other — it does not ask whether Beta-sitosterol is a good idea for someone in your situation. Here is what our Beta-sitosterol record says about it on its own.

Beta-sitosterol: dosing

There is no single official dose of beta-sitosterol for all uses. The amount used in studies varies depending on the condition being studied, and product strengths differ between brands.The best approach is to follow the directions on the product label and not take more than recommended.

From our Beta-sitosterol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Beta-sitosterol monograph & all interactions
Medication

About Tolazamide

What Is Tolazamide Used For?

Brand name: Tolinase

  • Tolazamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolazamide is in a class of medications called sulfonylureas. Tolazamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Tolazamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

See full Tolazamide drug information
Keep checking

Other Drugs & Beta-sitosterol

Browse every other medication we’ve checked against Beta-sitosterol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Beta-sitosterol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Beta-sitosterol list.

See the full Beta-sitosterol interactions page
See every supplement checked against Tolazamide, ranked by severity
Evidence & sources

Beta-sitosterol References

The 7 references that drive our Beta-sitosterol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
  3. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 1999;83:976-83. PubMed
  4. Oster P, Schlierf G, Heuck CC, et al. [Sitosterol in familial hyperlipoproteinemia type II. A randomized, double-blind, cross-over study]. Dtsch Med Wochenschr 1976;101:1308-11.
  5. Becker M, Staab D, Von Bergman K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 1992;89:138-42. DOI
  6. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  7. Lorenze A, Hsueh W, Nasr J. Beta-sitosterol-induced acute pancreatitis: A case report and review of the literature. Cureus. 2020;12(3):e7407. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Beta-sitosterol and Tolazamide Together: Common Questions

Is it safe to take Beta-sitosterol with Tolazamide?
We do not list a known interaction between Beta-sitosterol and Tolazamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tolazamide interact with any supplements?
Yes. Tolazamide has documented interactions with 272 supplements in our database — Beta-sitosterol is not one of them. The Tolazamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Beta-sitosterol monograph Uses, safety profile, and every drug interaction in one place Tolazamide drug information The full plain-English guide to this medication Tolazamide supplement interactions Every supplement checked against Tolazamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tolazamide and Beta-sitosterol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.