Medication interaction hub

What Supplements Interact with Tolazamide?

Tolazamide brand name: Tolinase. Every interaction below applies to the brands too.

272 Interactions 2 Major 230 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tolazamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tolazamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tolazamide (Tolinase) lowers blood sugar in type 2 diabetes, and I would handle its supplement list with care, because nearly everything listed can drag blood sugar lower still. Herbs and foods with glucose-lowering effects dominate the file, and stacked on a pill that already lowers glucose they raise the odds of hypoglycemia, blood sugar falling too far. Two entries rate major: Siberian cocklebur, which has caused severe hypoglycemia in people, and activated charcoal, which can bind the drug and weaken its effect.

A smaller cluster adds sun sensitivity, so a rash or burn after time outdoors is worth connecting to a new supplement. Bulky fibers and charcoal products can also cut how much of an oral dose gets absorbed, so leave a wide gap between them and the pill. That leaves a long tail, 230 moderate and 40 minor among the 272, but start by knowing the two majors cold.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 230 Minor 40 No known interaction 1,180

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Tolazamide: Top Interactions at a Glance

The most significant Tolazamide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 272 interacting ingredients — plus 1,180 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Tolazamide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Tolazamidei

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction Major Likelihood Probable Activated Charcoal + Tolazamidei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Tolazamide

All 1,452 ingredients in our database, ranked by severity — 272 with a Tolazamide interaction on file and 1,180 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tolazamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Blue Cohosh with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that blue cohosh might increase blood glucose levels.

Full Blue Cohosh + Tolazamide answer

Can you take Apple Cider Vinegar with Tolazamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Full Apple Cider Vinegar + Tolazamide answer

Can you take Coca with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antidiabetes drugs.

Full Coca + Tolazamide answer

Can you take Black Pepper with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Black Pepper + Tolazamide answer

Can you take Black Seed with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.

Full Black Seed + Tolazamide answer

Can you take Blood Irradiation Therapy with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research and one case report suggest that blood irradiation therapy may lower blood glucose levels.

Full Blood Irradiation Therapy + Tolazamide answer

Can you take Blue-green Algae with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.

Full Blue-green Algae + Tolazamide answer

Can you take Brewer's Yeast with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.

Full Brewer's Yeast + Tolazamide answer

Can you take Brickellia with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary research in animal models shows that brickellia and its constituents have hypoglycemic effects.

Full Brickellia + Tolazamide answer

Can you take Bupleurum with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might decrease the effects of antidiabetes drugs.

Full Bupleurum + Tolazamide answer

Can you take Cabbage with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cabbage + Tolazamide answer

Can you take Cajeput Oil with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal studies suggest that cajeput oil might have hypoglycemic effects.

Full Cajeput Oil + Tolazamide answer

Can you take Capers with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glyc...

Full Capers + Tolazamide answer

Can you take Capsicum with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.

Full Capsicum + Tolazamide answer

Can you take Caraway with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caraway might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Caraway + Tolazamide answer

Can you take Carnosine with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.

Full Carnosine + Tolazamide answer

Can you take Carqueja with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, carqueja might lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Full Carqueja + Tolazamide answer

Can you take Cashew with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Eating a diet that consists of high amounts of cashew might increase fasting blood glucose levels.

Full Cashew + Tolazamide answer

Can you take Cassia Auriculata with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabet...

Full Cassia Auriculata + Tolazamide answer

Can you take Cassia Cinnamon with Tolazamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.

Full Cassia Cinnamon + Tolazamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tolazamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tolazamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tolazamide sits in 3 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Tolazamide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Tolazamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tolazamide through this category.

About Tolazamide

Tolazamide is a prescription medication also sold under the brand name Tolinase. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Tolazamide  ·  Brand name: Tolinase.

See the full Tolazamide drug information

Related: does Tolazamide deplete any nutrients?

Tolazamide has 1 reported nutrient association in the research literature — see the Tolazamide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tolazamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tolazamide.

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Pharmacist Counseling Corner

Tolazamide & Supplements: Common Questions

What supplements interact with Tolazamide?
In our interaction database, 272 supplement and herbal ingredients have an interaction with Tolazamide on file — 2 rated major, 230 moderate, and 40 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Tolazamide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Tolazamide?
That depends entirely on which supplement. The honest answer for Tolazamide is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Tolinase have the same supplement interactions as Tolazamide?
Yes — Tolinase all contain Tolazamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Tolazamide deplete any vitamins or nutrients?
It might — Tolazamide has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Tolazamide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Tolazamide and my other medications?
This page covers Tolazamide against supplements and herbal ingredients. Checking Tolazamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tolazamide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.