Drug & supplement interaction

Wood Anemone + Tolazamide

Tolazamide brand name: Tolinase.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Wood Anemone and Tolazamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Wood Anemone and Tolazamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tolazamide and Wood Anemone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Wood Anemone at all — not against Tolazamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wood Anemone safety at a glance

Wood Anemone overall Avoid The fresh plant is toxic and irritating, so it is not recommended for general use.
Pregnancy Likely Unsafe When the fresh plant is used orally or topically. There is insufficient reliable information available about the safety of the oral or topical use of the dried,... Read the full pregnancy detail
Breastfeeding Likely Unsafe When the fresh plant is used orally or topically. There is insufficient reliable information available about the safety of the oral or topical use of the dried,... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tolazamide and Wood Anemone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Wood Anemone Itself Has Been Linked To

This is not an interaction — nothing below involves Tolazamide. It is the side-effect record for Wood Anemone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Wood Anemone, this list is the first place to look.

  • Diarrhea Additional detail

    “Orally, the ingestion of freshly harvested wood anemone can cause colic, diarrhea, and severe irritation to the gastrointestinal tract and the urinary drainage passages (18).”

    Wood Anemone · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Wood Anemone — expand a row for the licensed statement it rests on. We haven’t matched Tolazamide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Tolazamide.

Special populations

Wood Anemone in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When the fresh plant is used orally or topically. There is insufficient reliable information available about the safety of the oral or topical use of the dried, cut plant during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Tolazamide

This page covers Wood Anemone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolazamide page lists 272 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 230 moderate · 40 minor.

From our pharmacist’s overview on the Tolazamide page

“Tolazamide (Tolinase) lowers blood sugar in type 2 diabetes, and I would handle its supplement list with care, because nearly everything listed can drag blood sugar lower still. Herbs and foods with glucose-lowering effects dominate the file, and stacked on a pill that already lowers glucose they raise the odds of hypoglycemia, blood s…”

Reviewed by 2 · Jul 18, 2026

Open the Tolazamide interaction page

How much people look this up

Where Wood Anemone and Tolazamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wood Anemone
Steady interest

#1,428 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolazamide
Steady interest

#2,453 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wood Anemone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Wood Anemone and Tolazamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wood Anemone

What is Wood Anemone?

  • Headache and migraine (traditional)
  • Joint and muscle aches (traditional)
  • Skin conditions (traditional/topical)
  • Menstrual complaints (folk use)
  • Homeopathic remedy (Pulsatilla-type uses)

Wood Anemone is a spring woodland flower in the buttercup family that contains an irritant compound and is considered toxic when fresh. It has a history of folk and homeopathic use, but there is no good scientific evidence that it works for any condition, and it is not recommended as a self-care supplement.

Anemone nemorosa · Ranunculaceae · Aerial parts (leaves and flowers); historically the whole fresh plant · Rarely used today; historically as a fresh-plant tincture or homeopathic preparation

An interaction check asks whether these two react with each other — it does not ask whether Wood Anemone is a good idea for someone in your situation. Here is what our Wood Anemone record says about it on its own.

Wood Anemone: dosing

There is no established or recommended safe dose of Wood Anemone as a supplement. Do not prepare or take homemade products from the wild plant.

From our Wood Anemone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wood Anemone monograph & all interactions
Medication

About Tolazamide

What Is Tolazamide Used For?

Brand name: Tolinase

  • Tolazamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolazamide is in a class of medications called sulfonylureas. Tolazamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Tolazamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

See full Tolazamide drug information
Keep checking

Other Drugs & Wood Anemone

Browse every other medication we’ve checked against Wood Anemone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Wood Anemone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Wood Anemone list.

See the full Wood Anemone interactions page
See every supplement checked against Tolazamide, ranked by severity
Evidence & sources

Wood Anemone References

The 1 references that drive our Wood Anemone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wood Anemone and Tolazamide Together: Common Questions

Is it safe to take Wood Anemone with Tolazamide?
We do not list a known interaction between Wood Anemone and Tolazamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tolazamide interact with any supplements?
Yes. Tolazamide has documented interactions with 272 supplements in our database — Wood Anemone is not one of them. The Tolazamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wood Anemone monograph Uses, safety profile, and every drug interaction in one place Tolazamide drug information The full plain-English guide to this medication Tolazamide supplement interactions Every supplement checked against Tolazamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tolazamide and Wood Anemone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.