Calcium D-glucarate + Tolazamide
Tolazamide brand name: Tolinase.
We found no known interaction between Calcium D-glucarate and Tolazamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Calcium D-glucarate and Tolazamide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tolazamide and Calcium D-glucarate in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Calcium D-glucarate safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Tolazamide
Interactions in our licensed database are recorded against drug classes, not just single drug names. Tolazamide is filed under 3 classifications — antidiabetes drugs, photosensitizing drugs, oral drugs. Calcium D-glucarate has documented interactions with 3 drug classes — the most serious being alcohol (ethanol) (moderate), glucuronidated drugs (moderate) and kanamycin (minor) — and none of Tolazamide’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Calcium D-glucarate Does Interact With Other Medications
Calcium D-glucarate has 125 moderate, 1 minor known drug interactions in our database — Tolazamide isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Calcium D-glucarate
We haven’t checked that one against Calcium D-glucarate yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Calcium D-glucarate. Pick one to open its full report.
See Every Supplement That Interacts With Tolazamide
This page covers Calcium D-glucarate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolazamide page lists 272 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).
By severity: 2 major · 230 moderate · 40 minor.
From our pharmacist’s overview on the Tolazamide page
“Tolazamide (Tolinase) lowers blood sugar in type 2 diabetes, and I would handle its supplement list with care, because nearly everything listed can drag blood sugar lower still. Herbs and foods with glucose-lowering effects dominate the file, and stacked on a pill that already lowers glucose they raise the odds of hypoglycemia, blood s…”
Reviewed by 2 · Jul 18, 2026
Taking Calcium D-glucarate as Part of a Dietary Supplement Product? Check It for Interactions
We hold 369 real supplement products containing Calcium D-glucarate, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calcium D-glucarate. Even though Calcium D-glucarate itself has no known interaction with Tolazamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Calcium D-glucarate and Tolazamide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#471 of 1,452 supplements looked up here in the last 7 days
#587 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calcium D-glucarate reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Calcium D-glucarate and Tolazamide records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Calcium D-glucarate
What is Calcium D-glucarate?
- Detoxification support
- Hormone balance
- Estrogen metabolism
- Liver support
- General wellness
Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence for these benefits is very limited, and most research comes from laboratory or animal studies. Talk to your pharmacist or doctor before using it, especially if you have a hormone-related condition.
Not applicable (a calcium salt of D-glucaric acid) · Tablets, capsules
An interaction check asks whether these two react with each other — it does not ask whether Calcium D-glucarate is a good idea for someone in your situation. Here is what our Calcium D-glucarate record says about it on its own.
Calcium D-glucarate: dosing
There is no official or standardized dose for calcium D-glucarate, and the best dose for any health goal has not been established in humans. Amounts used in supplements vary widely from product to product.The safest approach is to follow the directions on the product label and not exceed the recommended amount.
From our Calcium D-glucarate monograph — the full record covers uses, side effects and every documented interaction.
About Tolazamide
What Is Tolazamide Used For?
Brand name: Tolinase
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Tolazamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolazamide is in a class of medications called sulfonylureas. Tolazamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Tolazamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).
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Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
Other Drugs & Calcium D-glucarate
Browse every other medication we’ve checked against Calcium D-glucarate — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
125 interactions
- Apomorphine ›
- Doxorubicin ›
- Morphine Sulfate ›
- Acetaminophen ›
- Conjugated Estrogens ›
- Diazepam ›
- Meprobamate ›
- Digoxin ›
- Deferasirox ›
- Esterified Estrogens ›
- Irinotecan ›
- Lovastatin ›
- Pitavastatin ›
- Tamoxifen Citrate ›
- Apomorphine Hydrochloride ›
- Atorvastatin ›
- Atorvastatin Calcium ›
- Belinostat ›
- Belzutifan ›
- Cabotegravir ›
- Cabotegravir Sodium ›
- Dolutegravir ›
- Enasidenib ›
- Entacapone ›
- Ethanol ›
- Ezogabine ›
- Lamotrigine ›
- Lorazepam ›
- Oxazepam ›
- Paracetamol ›
- Pexidartinib Hydrochloride ›
- Raltegravir ›
- Sacituzumab Govitecan-hziy ›
- Simvastatin ›
- Simvastatin/ezetimibe ›
- Sorafenib ›
- Sotagliflozin ›
- Toremifene Citrate ›
- Irinotecan Hydrochloride ›
- Acetaminophen, Hydrocodone ›
- Acetaminophen, Butalbital ›
- Acetaminophen, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Pseudoephedrine ›
- Acetaminophen, Butalbital, Caffeine ›
- Acetaminophen, Caffeine, Codeine ›
- Acetaminophen, Dextromethorphan, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine ›
- Acetaminophen, Dichloralantipyrine, Isometheptene ›
- Acetaminophen, Oxycodone ›
- Acetaminophen, Propoxyphene ›
- Acetaminophen, Aspirin, Caffeine ›
- Acetaminophen, Caffeine, Codeine, Salicylamide ›
- Acetaminophen, Caffeine, Dihydrocodeine ›
- Acetaminophen, Chlorpheniramine, Phenylephrine ›
- Acetaminophen, Chlorzoxazone ›
- Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine ›
- Acetaminophen, Diphenhydramine, Pseudoephedrine ›
- Acetaminophen, Pamabrom, Pyrilamine ›
- Acetaminophen, Butalbital, Caffeine, Codeine ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine ›
Showing 60 of 125 moderate interactions — see all 125 on the Calcium D-glucarate page.
1 interaction
No interaction 2,703 drugs checked — show the list
We also checked Calcium D-glucarate against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Docusate ›
- Abemaciclib ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Acyclovir ›
- Amitriptyline ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Gabapentin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Methylene Blue ›
- Clonazepam ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Naproxen ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Cyclopentolate ›
Showing the 60 most looked-up of 2,703 medications checked with no known interaction — see the full Calcium D-glucarate list.
Calcium D-glucarate References
The 5 references that drive our Calcium D-glucarate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
- Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
- Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
- Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
- Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Tolazamide Is Linked to Lower Levels of One Nutrient
Natural Medicines records Tolazamide as a medicine that can lower these. This is not an interaction with Calcium D-glucarate — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Tolazamide nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Calcium D-glucarate and Tolazamide Together: Common Questions
Is it safe to take Calcium D-glucarate with Tolazamide?
How was the Calcium D-glucarate and Tolazamide combination checked?
Does Calcium D-glucarate interact with any other medications?
Does Tolazamide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.