Drug & supplement interaction

Cod Liver Oil + Tolazamide

Tolazamide brand name: Tolinase.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cod Liver Oil has a moderate interaction with Tolazamide. Theoretically, taking cod liver oil with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceA
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cod Liver Oil and Tolazamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Tolazamide

Tolazamide falls under ANTIDIABETES DRUGS — the group Cod Liver Oil interacts with.

Theoretically, taking cod liver oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that cod liver oil may lower blood glucose levels in women with gestational diabetes who are already taking antidiabetes drugs when used for at least 12 weeks. However, it does not appear to have any effect on blood glucose when used for shorter durations. Until more is known, use caution.
Severity Moderate Likelihood Possible Evidence A

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: Tolazamide already lowers your blood sugar by nudging your pancreas to release more insulin. Cod liver oil, thanks to its omega-3 fatty acids, may add a small extra blood-sugar-lowering nudge of its own. Stack the two and there's a chance your sugar could drop a little lower than expected, which is what we call hypoglycemia (shakiness, sweating, dizziness, or feeling foggy).

Now, the honest part: this effect was mostly seen with longer, daily use (around 12 weeks or more), and shorter use didn't seem to move blood sugar much. So an occasional dose is unlikely to be dramatic. If you take cod liver oil regularly, just keep an eye on your home glucose readings and chat with your pharmacist or doctor before changing anything.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Yang S, Lin R, Si L, et al. Cod-liver oil improves metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: A double-blind randomized controlled trial. J Diabetes Res. 2019;2019:7074042. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cod Liver Oil Also Interacts With Other Medications

Cod Liver Oil has 374 moderate known drug interactions in our database — the Tolazamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 374 No known interaction 2,456 (incl. Tolazamide)
Taking anything else?

Check Another of Your Medications Against Cod Liver Oil

Covers the 2,830 medications we’ve checked against Cod Liver Oil. Pick one to open its full report.

From our Q&A

Questions About Cod Liver Oil or Tolazamide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cod Liver Oil or Tolazamide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tolazamide

This page covers Cod Liver Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolazamide page lists 272 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 230 moderate · 40 minor.

From our pharmacist’s overview on the Tolazamide page

“Tolazamide (Tolinase) lowers blood sugar in type 2 diabetes, and I would handle its supplement list with care, because nearly everything listed can drag blood sugar lower still. Herbs and foods with glucose-lowering effects dominate the file, and stacked on a pill that already lowers glucose they raise the odds of hypoglycemia, blood s…”

Reviewed by 2 · Jul 18, 2026

Open the Tolazamide interaction page

One more smart check

Taking Cod Liver Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 17 real supplement products containing Cod Liver Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cod Liver Oil. Your product may carry other ingredients that interact with Tolazamide too, on top of Cod Liver Oil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cod Liver Oil and Tolazamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cod Liver Oil
Steady interest

#1,176 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolazamide
Top half

#816 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cod Liver Oil

What is Cod Liver Oil?

Cod Liver Oil
  • Source of omega-3 fatty acids
  • Vitamin A and D supplementation
  • Heart health
  • Joint and bone health
  • Reducing inflammation

Cod liver oil supplies omega-3 fatty acids (EPA and DHA) along with vitamins A and D, and is popular for heart, joint, and general health support. Evidence is strongest for its nutrient content, but proof of specific disease benefits is mixed. Because it contains vitamin A, taking too much can be harmful, so check with your pharmacist or doctor before using it.

Read the full Cod Liver Oil monograph & all interactions
Medication

About Tolazamide

What Is Tolazamide Used For?

Brand name: Tolinase

  • Tolazamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolazamide is in a class of medications called sulfonylureas. Tolazamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Tolazamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

See full Tolazamide drug information
Keep checking

Other Drugs & Cod Liver Oil

Browse every other medication we’ve checked against Cod Liver Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
374Moderate
0Minor
2,455No known interaction
374 Moderate 2,455 No interaction
Moderate

374 interactions

Showing 60 of 374 moderate interactions — see all 374 on the Cod Liver Oil page.

No interaction 2,455 drugs checked — show the list

We also checked Cod Liver Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,455 medications checked with no known interaction — see the full Cod Liver Oil list.

See the full Cod Liver Oil interactions page
See every supplement checked against Tolazamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cod Liver Oil monograph › Uses, safety, and every drug interaction in one place Tolazamide supplement interactions › Every supplement checked against Tolazamide, ranked by severity Tolazamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cod Liver Oil and Tolazamide Together: Common Questions

Can you take Cod Liver Oil with Tolazamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cod Liver Oil and Tolazamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tolazamide and Cod Liver Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.