Bitter Yam + Atovaquone, Proguanil
Atovaquone, Proguanil brand name: Malarone.
We found no known interaction between Bitter Yam and Atovaquone, Proguanil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atovaquone, Proguanil states a food rule worth keeping to.
Bitter Yam and Atovaquone, Proguanil
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Atovaquone, Proguanil and Bitter Yam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Bitter Yam safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Atovaquone, Proguanil
Interactions in our licensed database are recorded against drug classes, not just single drug names. Atovaquone, Proguanil is filed under 3 classifications — cytochrome p450 2c19 (cyp2c19) substrates, seizure threshold lowering drugs, oral drugs. Bitter Yam has documented interactions with 1 drug class — the most serious being digoxin (lanoxin) (moderate) — and none of Atovaquone, Proguanil’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Bitter Yam Does Interact With Other Medications
Bitter Yam has 1 moderate known drug interaction in our database — Atovaquone, Proguanil isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Bitter Yam
We haven’t checked that one against Bitter Yam yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Bitter Yam. Pick one to open its full report.
Some Atovaquone, Proguanil Products Have a Food Rule — Bitter Yam Should Not Break It
At least one FDA label for a product containing Atovaquone, Proguanil says to take it with food. If you take Bitter Yam on an empty stomach out of habit, keep them separate — and take Atovaquone, Proguanil with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atovaquone, Proguanil products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION The daily dose should be taken at the same time each day with food or a milky drink.
From the Dosage and Administration section of the FDA label we read for Atovaquone, Proguanil — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Atovaquone, Proguanil
This page covers Bitter Yam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atovaquone, Proguanil page lists 54 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Artichoke (moderate), Bacopa (moderate) and Baikal Skullcap (moderate).
By severity: 1 major · 40 moderate · 13 minor.
From our pharmacist’s overview on the Atovaquone, Proguanil page
“Most people taking atovaquone-proguanil (Malarone) are travelers trying to prevent malaria, so this list of 54 interacting supplements deserves real attention, since anything that weakens the drug can leave you exposed to the disease itself. The single major-rated entry is activated charcoal, a common travel remedy for stomach upset, w…”
Reviewed by 2 · Jul 18, 2026
Where Bitter Yam and Atovaquone, Proguanil Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#660 of 1,452 supplements looked up here in the last 7 days
#1,520 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bitter Yam reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bitter Yam and Atovaquone, Proguanil records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Bitter Yam
What is Bitter Yam?
- Blood sugar support
- Digestive complaints
- Traditional food source
- Wound and skin care (folk use)
Bitter yam is a wild African yam used traditionally as both food and folk medicine, often for blood sugar and digestion. Scientific evidence in humans is very limited, and some bitter yam species can be toxic if not properly prepared. Talk to a pharmacist or doctor before using it as a supplement.
Dioscorea dumetorum · Dioscoreaceae · Tuber (root) · Cooked tuber, dried powder, traditional preparations
An interaction check asks whether these two react with each other — it does not ask whether Bitter Yam is a good idea for someone in your situation. Here is what our Bitter Yam record says about it on its own.
Bitter Yam: dosing
There is no established, standardized dose of bitter yam as a supplement. Traditional use varies widely and depends on how the tuber is prepared.If you choose to use a commercial product, follow the directions on the label and do not take more than recommended.
From our Bitter Yam monograph — the full record covers uses, side effects and every documented interaction.
About Atovaquone and Proguanil
What Is Atovaquone and Proguanil Used For?
Brand name: Malarone
Atovaquone and proguanil is used for two purposes: preventing P. falciparum malaria before and during travel to areas where malaria is common, and treating an active, uncomplicated P. falciparum malaria infection. This includes regions where other antimalarials — such as chloroquine, mefloquine, halofantrine, and amodiaquine — may no longer be effective due to drug resistance.
Both the adult-strength and pediatric-strength tablet formulations share these same two approved uses. The brand Malarone is approved for both prevention and treatment of P. falciparum malaria in adults and in pediatric patients, with dosing based on body weight for children.
Other Drugs & Bitter Yam
Browse every other medication we’ve checked against Bitter Yam — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Bitter Yam against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Valacyclovir ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Amitriptyline ›
- Isotretinoin ›
- Methotrexate ›
- Bupropion ›
- Bendamustine ›
- Amlodipine Besylate ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Naproxen ›
- Letrozole ›
- Duloxetine ›
- Levothyroxine, Liothyronine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Bitter Yam list.
Bitter Yam References
The 1 references that drive our Bitter Yam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Nimenibo-Uadia R. Control of hyperlipidaemia, hypercholesterolaemia and hyperketonaemia by aqueous extract of Dioscorea dumetorum tuber. Trop J Pharm Res 2003;2:183-9. Available at: http://www.bioline.org.br/request?pr03009. DOI
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Bitter Yam and Atovaquone, Proguanil Together: Common Questions
Is it safe to take Bitter Yam with Atovaquone, Proguanil?
Should I take Bitter Yam and Atovaquone, Proguanil at the same time of day?
How was the Bitter Yam and Atovaquone, Proguanil combination checked?
Does Bitter Yam interact with any other medications?
Does Atovaquone, Proguanil interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.