Bitter Yam + Meperidine, Promethazine
Meperidine, Promethazine brand names: Meprozine, Mepergan.
We found no known interaction between Bitter Yam and Meperidine, Promethazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Bitter Yam and Meperidine, Promethazine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Meperidine, Promethazine and Bitter Yam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Bitter Yam safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Meperidine, Promethazine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Meperidine, Promethazine is filed under 11 classifications — including phenothiazines, narcotic drugs, serotonergic drugs. Bitter Yam has documented interactions with 1 drug class — the most serious being digoxin (lanoxin) (moderate) — and none of Meperidine, Promethazine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Bitter Yam Does Interact With Other Medications
Bitter Yam has 1 moderate known drug interaction in our database — Meperidine, Promethazine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Bitter Yam
We haven’t checked that one against Bitter Yam yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Bitter Yam. Pick one to open its full report.
See Every Supplement That Interacts With Meperidine, Promethazine
This page covers Bitter Yam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Meperidine, Promethazine page lists 207 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Henbane (major).
By severity: 10 major · 160 moderate · 37 minor.
From our pharmacist’s overview on the Meperidine, Promethazine page
“Meprozine combines meperidine, an opioid painkiller, with promethazine, a sedating antihistamine, so it already slows the brain on two fronts. I would read this list of 207 supplements and herbal ingredients with genuine care, starting with the 10 rated major.”
Reviewed by 2 · Jul 18, 2026
Where Bitter Yam and Meperidine, Promethazine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#912 of 1,452 supplements looked up here in the last 7 days
#273 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bitter Yam reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bitter Yam and Meperidine, Promethazine records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Bitter Yam
What is Bitter Yam?
- Blood sugar support
- Digestive complaints
- Traditional food source
- Wound and skin care (folk use)
Bitter yam is a wild African yam used traditionally as both food and folk medicine, often for blood sugar and digestion. Scientific evidence in humans is very limited, and some bitter yam species can be toxic if not properly prepared. Talk to a pharmacist or doctor before using it as a supplement.
Dioscorea dumetorum · Dioscoreaceae · Tuber (root) · Cooked tuber, dried powder, traditional preparations
An interaction check asks whether these two react with each other — it does not ask whether Bitter Yam is a good idea for someone in your situation. Here is what our Bitter Yam record says about it on its own.
Bitter Yam: dosing
There is no established, standardized dose of bitter yam as a supplement. Traditional use varies widely and depends on how the tuber is prepared.If you choose to use a commercial product, follow the directions on the label and do not take more than recommended.
From our Bitter Yam monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Bitter Yam
Browse every other medication we’ve checked against Bitter Yam — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Bitter Yam against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Abemaciclib ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Acyclovir ›
- Amitriptyline ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Acetaminophen, Codeine ›
- Lamotrigine ›
- Amphetamine ›
- Pregabalin ›
- Gabapentin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Methylene Blue ›
- Clonazepam ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Naproxen ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Bitter Yam list.
Bitter Yam References
The 1 references that drive our Bitter Yam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Nimenibo-Uadia R. Control of hyperlipidaemia, hypercholesterolaemia and hyperketonaemia by aqueous extract of Dioscorea dumetorum tuber. Trop J Pharm Res 2003;2:183-9. Available at: http://www.bioline.org.br/request?pr03009. DOI
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Bitter Yam and Meperidine, Promethazine Together: Common Questions
Is it safe to take Bitter Yam with Meperidine, Promethazine?
How was the Bitter Yam and Meperidine, Promethazine combination checked?
Does Bitter Yam interact with any other medications?
Does Meperidine, Promethazine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.