Medication interaction hub

What Supplements Interact with Meperidine, Promethazine?

Meperidine, Promethazine brand names: Meprozine, Mepergan. Every interaction below applies to the brands too.

207 Interactions 10 Major 160 Moderate 37 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Meperidine, Promethazine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Meperidine, Promethazine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Meprozine combines meperidine, an opioid painkiller, with promethazine, a sedating antihistamine, so it already slows the brain on two fronts. I would read this list of 207 supplements and herbal ingredients with genuine care, starting with the 10 rated major. Most of the worst pairings pile on more sedation: alcohol in any form, kava, and GHB-type products can deepen drowsiness into slowed breathing. Herbs with anticholinergic activity add to promethazine's drying, confusing side effects.

The 160 moderate and 37 minor entries mostly repeat these themes in gentler form. Meperidine can also trigger serotonin syndrome, a dangerous buildup of serotonin, and about 20 ingredients here push in that direction. Others raise sun sensitivity or, like activated charcoal, soak up the medication before your body absorbs it. If a product makes you sleepy, assume it stacks with this one, and read the major entries first.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 160 Minor 37 No known interaction 1,245

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Meperidine, Promethazine: Top Interactions at a Glance

The most significant Meperidine, Promethazine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 207 interacting ingredients — plus 1,245 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Meperidine, Promethazine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Meperidine, Promethazinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Meperidine, Promethazinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Meperidine, Promethazinei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Meperidine, Promethazinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Meperidine, Promethazinei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Henbane + Meperidine, Promethazinei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction
The complete list

Every Supplement Checked Against Meperidine, Promethazine

All 1,452 ingredients in our database, ranked by severity — 207 with a Meperidine, Promethazine interaction on file and 1,245 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Meperidine, Promethazine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Agar with Meperidine, Promethazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Meperidine, Promethazine answer

Can you take Tianeptine with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Meperidine, Promethazine answer

Can you take Marsh Labrador Tea with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Marsh Labrador tea can potentiate effects of barbiturates and alcohol.

Full Marsh Labrador Tea + Meperidine, Promethazine answer

Can you take Melatonin with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Full Melatonin + Meperidine, Promethazine answer

Can you take Methylene Blue with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Full Methylene Blue + Meperidine, Promethazine answer

Can you take Motherwort with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.

Full Motherwort + Meperidine, Promethazine answer

Can you take N,n-dmpea with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6).

Full N,n-dmpea + Meperidine, Promethazine answer

Can you take Nutmeg with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.

Full Nutmeg + Meperidine, Promethazine answer

Can you take Oregon Grape with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Meperidine, Promethazine answer

Can you take Panax Ginseng with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase levels of drugs metabolized by CYP2D6.

Full Panax Ginseng + Meperidine, Promethazine answer

Can you take Passion Flower with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Full Passion Flower + Meperidine, Promethazine answer

Can you take Phellodendron with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase the sedative effects of CNS depressants.

Full Phellodendron + Meperidine, Promethazine answer

Can you take Phenethylamine (pea) with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.

Full Phenethylamine (pea) + Meperidine, Promethazine answer

Can you take Phenibut with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.

Full Phenibut + Meperidine, Promethazine answer

Can you take Phosphatidylserine with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Full Phosphatidylserine + Meperidine, Promethazine answer

Can you take Pinellia Ternata with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Meperidine, Promethazine answer

Can you take Pomegranate with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Full Pomegranate + Meperidine, Promethazine answer

Can you take Poria Mushroom with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.

Full Poria Mushroom + Meperidine, Promethazine answer

Can you take Propolis with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.

Full Propolis + Meperidine, Promethazine answer

Can you take Psilocybin with Meperidine, Promethazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining psilocybin with serotonergic drugs might cause additive serotonergic effects.

Full Psilocybin + Meperidine, Promethazine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Meperidine, Promethazine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Meperidine, Promethazine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Meperidine, Promethazine sits in 11 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Phenothiazines 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Meperidine, Promethazine through this category.

Meperidine (Demerol) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Meperidine, Promethazine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Meperidine, Promethazine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Meperidine, Promethazine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Meperidine, Promethazine.

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Pharmacist Counseling Corner

Meperidine, Promethazine & Supplements: Common Questions

What supplements interact with Meperidine, Promethazine?
More than you might expect — 207 in total, though they are far from equal: 10 are rated major, 160 moderate, and 37 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Meperidine, Promethazine supplement interactions are the most serious?
The 10 major-rated combinations — led by Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb) — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Meperidine, Promethazine?
Usually yes — most people on Meperidine, Promethazine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Meprozine have the same supplement interactions as Meperidine, Promethazine?
Yes — Meprozine, Mepergan all contain Meperidine, Promethazine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Meperidine, Promethazine and my other medications?
This page covers Meperidine, Promethazine against supplements and herbal ingredients. Checking Meperidine, Promethazine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.