Drug & supplement interaction

7-keto-dhea + Meperidine, Promethazine

Meperidine, Promethazine brand names: Meprozine, Mepergan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between 7-keto-dhea and Meperidine, Promethazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

7-keto-dhea and Meperidine, Promethazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Meperidine, Promethazine and 7-keto-dhea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for 7-keto-dhea at all — not against Meperidine, Promethazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

7-keto-dhea safety at a glance

7-keto-dhea overall Use caution Short-term use appears generally tolerated in small studies, but long-term safety is not well established.
Pregnancy Avoid Not enough safety data, and hormone-related supplements are best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information is available, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Meperidine, Promethazine and 7-keto-dhea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What 7-keto-dhea Itself Has Been Linked To

This is not an interaction — nothing below involves Meperidine, Promethazine. It is the side-effect record for 7-keto-dhea on its own, from the licensed Natural Medicines monograph. If something new turns up after you add 7-keto-dhea, this list is the first place to look.

  • Dizziness Additional detail

    “Orally, 7-keto-DHEA has been associated with one report of vertigo in one clinical study.”

    7-keto-dhea · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 92185. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed
  • Nausea Additional detail

    “Orally, 7-keto-DHEA has been associated with two reports of nausea in one clinical study.”

    7-keto-dhea · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 92185. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed

Everything above comes from the Natural Medicines adverse-effect record for 7-keto-dhea — expand a row for the licensed statement it rests on. We haven’t matched Meperidine, Promethazine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Meperidine, Promethazine.

Everything else you take

See Every Supplement That Interacts With Meperidine, Promethazine

This page covers 7-keto-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Meperidine, Promethazine page lists 207 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Henbane (major).

By severity: 10 major · 160 moderate · 37 minor.

From our pharmacist’s overview on the Meperidine, Promethazine page

“Meprozine combines meperidine, an opioid painkiller, with promethazine, a sedating antihistamine, so it already slows the brain on two fronts. I would read this list of 207 supplements and herbal ingredients with genuine care, starting with the 10 rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Meperidine, Promethazine interaction page

One more smart check

Taking 7-keto-dhea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 207 real supplement products containing 7-keto-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-keto-dhea. Even though 7-keto-dhea itself has no known interaction with Meperidine, Promethazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 7-keto-dhea and Meperidine, Promethazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 7-keto-dhea
Top half

#444 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Meperidine, Promethazine
Top 10%

#273 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 7-keto-dhea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 7-keto-dhea and Meperidine, Promethazine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 7-keto-dhea

What is 7-keto-dhea?

7-keto-dhea
  • Weight loss and fat burning
  • Boosting metabolism
  • Supporting muscle mass
  • Improving body composition
  • Anti-aging support

7-keto-DHEA is a lab-made metabolite of the hormone DHEA that is marketed mainly for weight loss and a faster metabolism. Unlike DHEA, it is not thought to convert into estrogen or testosterone, but the evidence that it helps with weight or metabolism is limited and comes from small studies. Talk with your pharmacist or doctor before trying it, especially if you have any health conditions.

Not applicable (a manufactured metabolite of DHEA) · Capsules, tablets, powders (often in weight-loss or 'metabolism' blends)

An interaction check asks whether these two react with each other — it does not ask whether 7-keto-dhea is a good idea for someone in your situation. Here is what our 7-keto-dhea record says about it on its own.

7-keto-dhea: dosing

There is no official or well-established standardized dose for 7-keto-DHEA. Doses used in studies and on product labels have varied, and we cannot recommend a specific amount.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our 7-keto-dhea monograph — the full record covers uses, side effects and every documented interaction.

Read the full 7-keto-dhea monograph & all interactions
Keep checking

Other Drugs & 7-keto-dhea

Browse every other medication we’ve checked against 7-keto-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked 7-keto-dhea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full 7-keto-dhea list.

See the full 7-keto-dhea interactions page
See every supplement checked against Meperidine, Promethazine, ranked by severity
Evidence & sources

7-keto-dhea References

The 2 references that drive our 7-keto-dhea monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Davidson M, Marwah A, Sawchuk RJ, et al. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clin Invest Med 2000;23:300-10..
  2. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 7-keto-dhea and Meperidine, Promethazine Together: Common Questions

Is it safe to take 7-keto-dhea with Meperidine, Promethazine?
We do not list a known interaction between 7-keto-dhea and Meperidine, Promethazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Meperidine, Promethazine interact with any supplements?
Yes. Meperidine, Promethazine has documented interactions with 207 supplements in our database — 7-keto-dhea is not one of them. The Meperidine, Promethazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

7-keto-dhea monograph Uses, safety profile, and every drug interaction in one place Meperidine, Promethazine supplement interactions Every supplement checked against Meperidine, Promethazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Meperidine, Promethazine and 7-keto-dhea?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.