Drug & supplement interaction

7-keto-dhea + Bupropion

Bupropion brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between 7-keto-dhea and Bupropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

7-keto-dhea and Bupropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bupropion and 7-keto-dhea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for 7-keto-dhea at all — not against Bupropion, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

7-keto-dhea safety at a glance

7-keto-dhea overall Use caution Short-term use appears generally tolerated in small studies, but long-term safety is not well established.
Pregnancy Avoid Not enough safety data, and hormone-related supplements are best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information is available, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bupropion and 7-keto-dhea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests 7-keto-dhea and Bupropion May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dizziness reported in 5.1% of FDA reports for Bupropion Additional detail

    7-keto-dhea

    “Orally, 7-keto-DHEA has been associated with one report of vertigo in one clinical study.”

    7-keto-dhea · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 92185. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed

    Bupropion

    Listed in the ADVERSE REACTIONS section of the FDA label for Bupropion, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea reported in 7.8% of FDA reports for Bupropion Additional detail

    7-keto-dhea

    “Orally, 7-keto-DHEA has been associated with two reports of nausea in one clinical study.”

    7-keto-dhea · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 92185. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed

    Bupropion

    Listed in the ADVERSE REACTIONS section of the FDA label for Bupropion, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Bupropion come from the ADVERSE REACTIONS section of its FDA label; effects for 7-keto-dhea come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 152,137 voluntary FDA FAERS reports for Bupropion that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Bupropion Is Prescribed For, and What 7-keto-dhea Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Bupropion is a prescription medicine with approved uses on its FDA label. 7-keto-dhea is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Bupropion is prescribed for: Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter. Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD.

Read the rest of what Bupropion is prescribed for

Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.

7-keto-dhea has been studied for:

  • Depression studied, not established 7-keto-dhea has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    7-keto-dhea for depression

    Although there has been interest in using oral 7-keto-DHEA for depression, there is insufficient reliable information about the clinical effects of 7-keto-DHEA for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Bupropion on your own; if you are taking 7-keto-dhea for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About 7-keto-dhea or Bupropion

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 7-keto-dhea or Bupropion, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bupropion

This page covers 7-keto-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 33 moderate · 12 minor.

From our pharmacist’s overview on the Bupropion page

“Bupropion (Wellbutrin, Zyban) deserves genuine care around supplements, and the entry to understand first is activated charcoal, the only major-rated interaction on this list. Charcoal and similar bulk products can soak up the drug in the gut and blunt its effect, so space them well apart from your dose.”

Reviewed by 2 · Jul 18, 2026

Open the Bupropion interaction page

One more smart check

Taking 7-keto-dhea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 207 real supplement products containing 7-keto-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-keto-dhea. Even though 7-keto-dhea itself has no known interaction with Bupropion, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 7-keto-dhea and Bupropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 7-keto-dhea
Top half

#488 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bupropion
Top 1%

#23 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 7-keto-dhea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 7-keto-dhea and Bupropion records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 7-keto-dhea

What is 7-keto-dhea?

7-keto-dhea
  • Weight loss and fat burning
  • Boosting metabolism
  • Supporting muscle mass
  • Improving body composition
  • Anti-aging support

7-keto-DHEA is a lab-made metabolite of the hormone DHEA that is marketed mainly for weight loss and a faster metabolism. Unlike DHEA, it is not thought to convert into estrogen or testosterone, but the evidence that it helps with weight or metabolism is limited and comes from small studies. Talk with your pharmacist or doctor before trying it, especially if you have any health conditions.

Not applicable (a manufactured metabolite of DHEA) · Capsules, tablets, powders (often in weight-loss or 'metabolism' blends)

An interaction check asks whether these two react with each other — it does not ask whether 7-keto-dhea is a good idea for someone in your situation. Here is what our 7-keto-dhea record says about it on its own.

7-keto-dhea: dosing

There is no official or well-established standardized dose for 7-keto-DHEA. Doses used in studies and on product labels have varied, and we cannot recommend a specific amount.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our 7-keto-dhea monograph — the full record covers uses, side effects and every documented interaction.

Read the full 7-keto-dhea monograph & all interactions
Medication

About Bupropion

What Is Bupropion Used For?

Brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, Forfivo XL

Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter.

Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD. Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.

Most-Reported Side Effects for Bupropion

From FAERS, the FDA’s public side-effect reporting system (152,137 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 11,909 reports
Fatigue 10,076 reports
Headache 10,053 reports
Depression 8,639 reports
Dizziness 7,786 reports
See full Bupropion drug information
Keep checking

Other Drugs & 7-keto-dhea

Browse every other medication we’ve checked against 7-keto-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked 7-keto-dhea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full 7-keto-dhea list.

See the full 7-keto-dhea interactions page
See every supplement checked against Bupropion, ranked by severity
Evidence & sources

7-keto-dhea References

The 2 references that drive our 7-keto-dhea monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Davidson M, Marwah A, Sawchuk RJ, et al. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clin Invest Med 2000;23:300-10..
  2. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 7-keto-dhea and Bupropion Together: Common Questions

Is it safe to take 7-keto-dhea with Bupropion?
We do not list a known interaction between 7-keto-dhea and Bupropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do 7-keto-dhea and Bupropion have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are 7-keto-dhea and Bupropion used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for 7-keto-dhea in each. That is a conversation for your prescriber, especially if Bupropion is being adjusted to a target.
Does Bupropion interact with any supplements?
Yes. Bupropion has documented interactions with 46 supplements in our database — 7-keto-dhea is not one of them. The Bupropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

7-keto-dhea monograph Uses, safety profile, and every drug interaction in one place Bupropion drug information The full plain-English guide to this medication Bupropion supplement interactions Every supplement checked against Bupropion, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bupropion and 7-keto-dhea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.