Drug & supplement interaction

Herb Paris + Meperidine, Promethazine

Meperidine, Promethazine brand names: Meprozine, Mepergan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Herb Paris and Meperidine, Promethazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Herb Paris and Meperidine, Promethazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Meperidine, Promethazine and Herb Paris in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Herb Paris at all — not against Meperidine, Promethazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Herb Paris safety at a glance

Herb Paris overall Avoid The raw plant is poisonous; only highly diluted homeopathic forms are considered low-risk, and even these lack proven benefit.
Pregnancy Unsafe When used orally. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Meperidine, Promethazine and Herb Paris? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Herb Paris Itself Has Been Linked To

This is not an interaction — nothing below involves Meperidine, Promethazine. It is the side-effect record for Herb Paris on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Herb Paris, this list is the first place to look.

  • Diarrhea / Vomiting / Nausea Additional detail

    “Orally, Herb Paris can cause nausea, vomiting, diarrhea, headache, miosis, and respiratory paralysis (18).”

    Herb Paris · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, Herb Paris can cause nausea, vomiting, and diarrhea (18).”

    Herb Paris · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Headache Additional detail

    “Orally, Herb Paris can cause headache (18).”

    Herb Paris · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Herb Paris — expand a row for the licensed statement it rests on. We haven’t matched Meperidine, Promethazine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Meperidine, Promethazine.

Special populations

Herb Paris in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Meperidine, Promethazine

This page covers Herb Paris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Meperidine, Promethazine page lists 207 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Henbane (major).

By severity: 10 major · 160 moderate · 37 minor.

From our pharmacist’s overview on the Meperidine, Promethazine page

“Meprozine combines meperidine, an opioid painkiller, with promethazine, a sedating antihistamine, so it already slows the brain on two fronts. I would read this list of 207 supplements and herbal ingredients with genuine care, starting with the 10 rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Meperidine, Promethazine interaction page

How much people look this up

Where Herb Paris and Meperidine, Promethazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Herb Paris
Steady interest

#1,383 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Meperidine, Promethazine
Top 25%

#396 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Herb Paris reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Herb Paris and Meperidine, Promethazine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Herb Paris

What is Herb Paris?

  • Headache and migraine (traditional/homeopathic use)
  • Nerve pain and neuralgia
  • Eye complaints (folk use)
  • Cough and bronchitis (folk use)
  • Inflammation and swelling (traditional use)

Herb Paris (Paris quadrifolia) is a poisonous woodland plant that has been used historically in folk medicine and is sold mainly in highly diluted homeopathic forms. There is no reliable scientific evidence that it treats any health condition, and the raw plant is toxic, so it should not be self-prescribed. Talk to a pharmacist or doctor before using any product containing it.

Paris quadrifolia · Melanthiaceae · Whole herb, rhizome (root), berries, and leaves · Homeopathic preparations (pellets, dilutions); rarely as dried herb

An interaction check asks whether these two react with each other — it does not ask whether Herb Paris is a good idea for someone in your situation. Here is what our Herb Paris record says about it on its own.

Herb Paris: dosing

There is no established safe or effective dose of Herb Paris. The raw plant is toxic, so it should not be self-dosed at all. Homeopathic products come in standardized dilution labels (such as different "C" or "X" potencies), but these reflect homeopathic convention rather than proven dosing.If you choose to use a commercial product, follow the directions on the label exactly and do not exceed them.

From our Herb Paris monograph — the full record covers uses, side effects and every documented interaction.

Read the full Herb Paris monograph & all interactions
Keep checking

Other Drugs & Herb Paris

Browse every other medication we’ve checked against Herb Paris — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Herb Paris against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Herb Paris list.

See the full Herb Paris interactions page
See every supplement checked against Meperidine, Promethazine, ranked by severity
Evidence & sources

Herb Paris References

The 1 references that drive our Herb Paris monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Herb Paris and Meperidine, Promethazine Together: Common Questions

Is it safe to take Herb Paris with Meperidine, Promethazine?
We do not list a known interaction between Herb Paris and Meperidine, Promethazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Meperidine, Promethazine interact with any supplements?
Yes. Meperidine, Promethazine has documented interactions with 207 supplements in our database — Herb Paris is not one of them. The Meperidine, Promethazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Herb Paris monograph Uses, safety profile, and every drug interaction in one place Meperidine, Promethazine supplement interactions Every supplement checked against Meperidine, Promethazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Meperidine, Promethazine and Herb Paris?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.