Black Nightshade + Bendamustine Hydrochloride
Bendamustine Hydrochloride brand name: Bendeka.
We found no known interaction between Black Nightshade and Bendamustine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Black Nightshade and Bendamustine Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Bendamustine Hydrochloride and Black Nightshade in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Black Nightshade at all — not against Bendamustine Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Black Nightshade safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Black Nightshade in Pregnancy & Breastfeeding
When used orally because of concerns it could be teratogenic; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Bendamustine Hydrochloride
This page covers Black Nightshade only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bendamustine Hydrochloride page lists 86 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Acerola (moderate), Adrafinil (moderate), African Wild Potato (moderate), Alpha-lipoic Acid (moderate) and Ashitaba (moderate).
By severity: 62 moderate · 24 minor.
From our pharmacist’s overview on the Bendamustine Hydrochloride page
“Bendamustine (Bendeka), a chemotherapy used for certain leukemias and lymphomas, carries 86 supplement and herbal interactions on file, and none of them rates major, so this is a watch-and-adjust list rather than an alarm. Nearly all of the entries, about 80, involve the same liver enzyme, CYP1A2, which helps process bendamustine.”
Reviewed by 2 · Jul 18, 2026
Taking Black Nightshade as Part of a Dietary Supplement Product? Check It for Interactions
We hold 37 real supplement products containing Black Nightshade, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Nightshade. Even though Black Nightshade itself has no known interaction with Bendamustine Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Black Nightshade and Bendamustine Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#694 of 1,452 supplements looked up here in the last 7 days
#531 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Nightshade reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Black Nightshade and Bendamustine Hydrochloride records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Black Nightshade
What is Black Nightshade?
- Digestive complaints
- Skin conditions
- Inflammation
- Fever
- Liver support (traditional)
Black nightshade is a wild plant whose cooked ripe berries and leaves are eaten as food in some cultures, but unripe berries and green parts can be poisonous. Human evidence for any health benefit is very limited, and the risk of toxicity is real. Do not use it as a supplement without medical guidance, and avoid it during pregnancy and breastfeeding.
Solanum nigrum · Solanaceae · Leaves, berries (ripe), and whole plant · Cooked leafy greens, fruit, traditional decoctions, dried herb, extracts
An interaction check asks whether these two react with each other — it does not ask whether Black Nightshade is a good idea for someone in your situation. Here is what our Black Nightshade record says about it on its own.
Black Nightshade: dosing
There is no established or standardized safe dose of black nightshade as a supplement. When it comes to wild plants, never guess at an amount or forage your own to use as medicine.
From our Black Nightshade monograph — the full record covers uses, side effects and every documented interaction.
About Bendamustine Injection
What Is Bendamustine Injection Used For?
Brand name: Bendeka
Bendamustine hydrochloride injection is used to treat adults with chronic lymphocytic leukemia (CLL). It is also used for adults with indolent B-cell non-Hodgkin lymphoma (NHL) — a slow-growing type of blood cancer — when the disease has continued to progress during or within six months of treatment with rituximab or a rituximab-containing regimen.
For CLL, how well bendamustine works compared to other first-line treatments (aside from chlorambucil) has not been fully established.
Most-Reported Side Effects for Bendamustine Hydrochloride
From FAERS, the FDA’s public side-effect reporting system (11,906 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Black Nightshade
Browse every other medication we’ve checked against Black Nightshade — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Black Nightshade against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Black Nightshade list.
Black Nightshade References
The 1 references that drive our Black Nightshade monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Dukes JA. CRC Handbook of Medicinal Herbs. first ed. Boca Raton, FL: CRC Press, Inc., 1985.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Bendamustine Hydrochloride Is Linked to Lower Levels of One Nutrient
Natural Medicines records Bendamustine Hydrochloride as a medicine that can lower these. This is not an interaction with Black Nightshade — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Bendamustine Hydrochloride nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Black Nightshade and Bendamustine Hydrochloride Together: Common Questions
Is it safe to take Black Nightshade with Bendamustine Hydrochloride?
Does Bendamustine Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Bendamustine Hydrochloride and Black Nightshade?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.