Drug & supplement interaction

Buck's-horn Plantain + Axitinib

Axitinib brand name: Inlyta.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Buck's-horn Plantain and Axitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Buck's-horn Plantain and Axitinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Axitinib and Buck's-horn Plantain in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Buck's-horn Plantain at all — not against Axitinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Buck's-horn Plantain safety at a glance

Buck's-horn Planta... overall Use caution Generally considered safe as a food, but medicinal use is poorly studied.
Pregnancy Avoid Not enough safety data for medicinal amounts, so avoid concentrated use.
Breastfeeding Avoid No reliable safety information during breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Axitinib and Buck's-horn Plantain? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Axitinib’s Own FDA Label Lists

This is not an interaction — none of it involves Buck's-horn Plantain. These are the most notable effects listed in the ADVERSE REACTIONS section of Axitinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A change in thyroid levels Worth acting on
  • A stroke or mini-stroke Worth acting on
  • Dehydration Worth acting on
  • High potassium Worth acting on
  • Low sodium Worth acting on
  • Blood clots Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on

Showing the 10 most notable of 38 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Axitinib. Read the label on DailyMed › Buck's-horn Plantain’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Buck's-horn Plantain side to compare — that is a limit of the record, not a statement that Buck's-horn Plantain has no side effects.

Everything else you take

See Every Supplement That Interacts With Axitinib

This page covers Buck's-horn Plantain only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Axitinib page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Axitinib page

“Grapefruit is the first thing I would take off the table on axitinib (Inlyta), a targeted therapy for advanced kidney cancer. It blocks the liver enzyme (CYP3A4) that clears axitinib, so levels climb and side effects with them.”

Reviewed by 2 · Jul 18, 2026

Open the Axitinib interaction page

How much people look this up

Where Buck's-horn Plantain and Axitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Buck's-horn Plantain
Steady interest

#1,310 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Axitinib
Steady interest

#2,727 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Buck's-horn Plantain is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Buck's-horn Plantain reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Buck's-horn Plantain and Axitinib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Buck's-horn Plantain

What is Buck's-horn Plantain?

  • Eaten as a leafy salad green
  • Digestive complaints
  • Soothing irritated skin (topical, traditional)
  • Mild diuretic (traditional)
  • General tonic in folk medicine

Buck's-horn plantain (Plantago coronopus) is mainly a edible coastal salad green that has also been used in folk medicine for digestion and minor skin or urinary complaints. There is very little human research to support any medicinal use, so it should be viewed as a nutritious food rather than a proven remedy. If you want to use it for a health condition, talk with a pharmacist or doctor first.

Plantago coronopus · Plantaginaceae · Leaves (and sometimes seeds) · Fresh leaves (as a salad green or potherb), dried herb, tea/infusion, occasionally poultices

An interaction check asks whether these two react with each other — it does not ask whether Buck's-horn Plantain is a good idea for someone in your situation. Here is what our Buck's-horn Plantain record says about it on its own.

Buck's-horn Plantain: dosing

There is no established standardized medicinal dose for buck's-horn plantain. It is most often used simply as a food, in the amounts you would eat any leafy green.If you choose to use a commercial product such as a dried herb or tea, follow the directions on the label and do not exceed the recommended amount.

From our Buck's-horn Plantain monograph — the full record covers uses, side effects and every documented interaction.

Read the full Buck's-horn Plantain monograph & all interactions
Medication

About Axitinib

What Is Axitinib Used For?

Brand name: Inlyta

Axitinib (brand name Inlyta) is used to treat advanced renal cell carcinoma (RCC), a type of kidney cancer. Inlyta can be used as a first-line treatment — meaning the very first treatment you receive — when combined with either avelumab or pembrolizumab, two other cancer medicines.

Inlyta is also approved as a single agent (on its own) for patients with advanced RCC who have already tried one other systemic (body-wide) cancer therapy that did not work or stopped working.

See full Axitinib drug information
Keep checking

Other Drugs & Buck's-horn Plantain

Browse every other medication we’ve checked against Buck's-horn Plantain — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Buck's-horn Plantain against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Buck's-horn Plantain list.

See the full Buck's-horn Plantain interactions page
See every supplement checked against Axitinib, ranked by severity
Evidence & sources

Buck's-horn Plantain References

The 1 sources that drive our Buck's-horn Plantain monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Buck's-horn Plantain is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Plantain (Plantago) information — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Buck's-horn Plantain and Axitinib Together: Common Questions

Is it safe to take Buck's-horn Plantain with Axitinib?
We do not list a known interaction between Buck's-horn Plantain and Axitinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Axitinib interact with any supplements?
Yes. Axitinib has documented interactions with 138 supplements in our database — Buck's-horn Plantain is not one of them. The Axitinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Buck's-horn Plantain monograph Uses, safety profile, and every drug interaction in one place Axitinib drug information The full plain-English guide to this medication Axitinib supplement interactions Every supplement checked against Axitinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Axitinib and Buck's-horn Plantain?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.