Drug & supplement interaction

Burr Marigold + Medroxyprogesterone

Medroxyprogesterone brand names: Provera, Amen, Depo-Provera, Depo-subQ Provera 104.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Burr Marigold and Medroxyprogesterone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Burr Marigold and Medroxyprogesterone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Medroxyprogesterone and Burr Marigold in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Burr Marigold at all — not against Medroxyprogesterone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Burr Marigold safety at a glance

Burr Marigold overall Use caution Limited human safety data, so use cautiously and discuss with a healthcare professional first.
Pregnancy Avoid Not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Medroxyprogesterone and Burr Marigold? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Medroxyprogesterone’s Own FDA Label Lists

This is not an interaction — none of it involves Burr Marigold. These are the most notable effects listed in the ADVERSE REACTIONS section of Medroxyprogesterone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Bone thinning Worth acting on
  • Low mood Worth acting on
  • A severe allergic reaction Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Changes to your period
  • A change in sex drive
  • Breast tenderness
  • Acne
  • Weight gain

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Medroxyprogesterone. Read the label on DailyMed › Where a percentage is shown, it is the share of 60,501 voluntary FDA FAERS reports for Medroxyprogesterone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Burr Marigold’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Burr Marigold side to compare — that is a limit of the record, not a statement that Burr Marigold has no side effects.

From our Q&A

Questions About Burr Marigold or Medroxyprogesterone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Burr Marigold or Medroxyprogesterone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Medroxyprogesterone

This page covers Burr Marigold only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Medroxyprogesterone page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 95 moderate · 41 minor.

From our pharmacist’s overview on the Medroxyprogesterone page

“Medroxyprogesterone (Provera, Depo-Provera) only works if its blood level holds steady, and 121 of the 139 supplements and herbs on file can shift that level through a single liver enzyme, CYP3A4. That makes this a list to respect, with three entries rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Medroxyprogesterone interaction page

How much people look this up

Where Burr Marigold and Medroxyprogesterone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Burr Marigold
Steady interest

#1,353 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Medroxyprogesterone
Steady interest

#1,952 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Burr Marigold is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Burr Marigold reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Burr Marigold and Medroxyprogesterone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Burr Marigold

What is Burr Marigold?

Burr Marigold
  • Minor wounds and skin irritation
  • Mild urinary complaints
  • Digestive upset
  • Coughs and colds
  • General 'cleansing' or diuretic effect

Burr Marigold (Bidens tripartita) is a wetland plant used in traditional medicine for wounds, urinary complaints, and digestive issues, but high-quality human research is lacking. Because its effectiveness and safety have not been well studied, it should be used cautiously, and avoided in pregnancy, breastfeeding, and in young children. Talk to a pharmacist or doctor before trying it.

Bidens tripartita · Asteraceae · Above-ground parts (herb), including leaves, stems, and flowering tops · Tea (dried herb infusion), tincture, liquid extract, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Burr Marigold is a good idea for someone in your situation. Here is what our Burr Marigold record says about it on its own.

Burr Marigold: dosing

There is no established standard dose for Burr Marigold. Traditional use has involved teas made from the dried herb, as well as tinctures and liquid extracts, but reliable dosing guidelines from clinical research do not exist.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Burr Marigold monograph — the full record covers uses, side effects and every documented interaction.

Read the full Burr Marigold monograph & all interactions
Medication

About Medroxyprogesterone

What Is Medroxyprogesterone Used For?

Brand names: Provera, Amen, Depo-Provera, Depo-subQ Provera 104

Medroxyprogesterone is used for different conditions depending on the product form. The injectable forms — including Depo-Provera and intramuscular medroxyprogesterone acetate injectable suspension — are used to prevent pregnancy. Depo-subQ Provera 104 (the subcutaneous injection) is also approved to manage pain associated with endometriosis.

The oral tablets — sold under the brand Provera and as generic medroxyprogesterone acetate tablets — treat secondary amenorrhea (periods that have stopped) and abnormal uterine bleeding caused by hormonal imbalance. The tablets are also used to prevent endometrial hyperplasia (abnormal thickening of the uterine lining) in postmenopausal women with a uterus who are taking daily conjugated estrogens.

Most-Reported Side Effects for Medroxyprogesterone

From FAERS, the FDA’s public side-effect reporting system (60,501 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Meningioma 11,278 reports
Breast cancer 10,971 reports
Breast cancer female 10,184 reports
Breast cancer metastatic 1,943 reports
Nausea 1,449 reports
See full Medroxyprogesterone drug information
Keep checking

Other Drugs & Burr Marigold

Browse every other medication we’ve checked against Burr Marigold — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Burr Marigold against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Burr Marigold list.

See the full Burr Marigold interactions page
See every supplement checked against Medroxyprogesterone, ranked by severity
Evidence & sources

Burr Marigold References

The 2 sources that drive our Burr Marigold monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Burr Marigold is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. MedlinePlus: Herbal Medicine — MedlinePlus (NIH) Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Burr Marigold and Medroxyprogesterone Together: Common Questions

Is it safe to take Burr Marigold with Medroxyprogesterone?
We do not list a known interaction between Burr Marigold and Medroxyprogesterone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Medroxyprogesterone interact with any supplements?
Yes. Medroxyprogesterone has documented interactions with 139 supplements in our database — Burr Marigold is not one of them. The Medroxyprogesterone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Burr Marigold monograph Uses, safety profile, and every drug interaction in one place Medroxyprogesterone drug information The full plain-English guide to this medication Medroxyprogesterone supplement interactions Every supplement checked against Medroxyprogesterone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Medroxyprogesterone and Burr Marigold?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.