Cannabidivarin (cbdv) + Upadacitinib Hemihydrate
Upadacitinib Hemihydrate brand name: Rinvoq.
We found no known interaction between Cannabidivarin (cbdv) and Upadacitinib Hemihydrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Cannabidivarin (cbdv) and Upadacitinib Hemihydrate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Upadacitinib Hemihydrate and Cannabidivarin (cbdv) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Cannabidivarin (cbdv) at all — not against Upadacitinib Hemihydrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cannabidivarin (cbdv) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Upadacitinib Hemihydrate Is Prescribed For, and What Cannabidivarin (cbdv) Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Upadacitinib Hemihydrate is a prescription medicine with approved uses on its FDA label. Cannabidivarin (cbdv) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Upadacitinib Hemihydrate is prescribed for: Upadacitinib is approved for adults and some children with moderate-to-severe inflammatory conditions when other treatments haven't worked well enough. It targets overactive immune signaling that drives these diseases. Conditions it treats include:Rheumatoid arthritis (RA) — in adults who didn't respond to TNF blocker medications Psoriatic arthritis — in adults and children 2 years and older who didn't respond to TNF blockers Atopic dermatitis (eczema) — in people 12 and older whose disease isn't controlled by other systemic therapies Ulcerative colitis — in adults who didn't respond to TNF blockers or other approved therapies Crohn's disease — in adults who didn't respond to TNF blockers or other approved therapies
Cannabidivarin (cbdv) has been studied for:
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Ulcerative colitis studied, not established Cannabidivarin (cbdv) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Cannabidivarin (cbdv) for ulcerative colitis
Although there is interest in using oral cannabidivarin for ulcerative colitis, there is insufficient reliable information about the clinical effects of cannabidivarin for this condition.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Upadacitinib Hemihydrate on your own; if you are taking Cannabidivarin (cbdv) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Upadacitinib Hemihydrate
This page covers Cannabidivarin (cbdv) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Upadacitinib Hemihydrate page lists 138 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 94 moderate · 41 minor.
From our pharmacist’s overview on the Upadacitinib Hemihydrate page
“Grapefruit is the pairing I would want anyone on Rinvoq (upadacitinib) to know about first. The drug is cleared by a liver enzyme called CYP3A4, and grapefruit blocks that enzyme, letting blood levels climb, which matters for a medicine that already dials down the immune system.”
Reviewed by 2 · Jul 18, 2026
Where Cannabidivarin (cbdv) and Upadacitinib Hemihydrate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,224 of 1,452 supplements looked up here in the last 7 days
#320 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabidivarin (cbdv) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Cannabidivarin (cbdv) and Upadacitinib Hemihydrate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cannabidivarin (cbdv)
What is Cannabidivarin (cbdv)?
- Epilepsy and seizures
- Autism spectrum disorder
- Rett syndrome
- Fragile X syndrome
- Nausea
- Anxiety
Cannabidivarin (CBDV) is a non-intoxicating compound found in cannabis that is being studied mainly for epilepsy and certain neurodevelopmental conditions. The research is still early, mostly from laboratory and animal studies plus small human trials, so it is not an approved or proven treatment. Talk to your pharmacist or doctor before trying any CBDV product.
Cannabaceae · Compound derived from the flowers and leaves of the cannabis plant · Oils, tinctures, isolates, and research-grade formulations
An interaction check asks whether these two react with each other — it does not ask whether Cannabidivarin (cbdv) is a good idea for someone in your situation. Here is what our Cannabidivarin (cbdv) record says about it on its own.
Cannabidivarin (cbdv): dosing
There is no established standard dose for CBDV. The amounts used in research studies were chosen for those specific trials and are not the same as general supplement guidance.If you choose to use a CBDV product, follow the directions on the product label and start low.
From our Cannabidivarin (cbdv) monograph — the full record covers uses, side effects and every documented interaction.
About Upadacitinib
What Is Upadacitinib Used For?
Brand name: Rinvoq
Upadacitinib is approved for adults and some children with moderate-to-severe inflammatory conditions when other treatments haven't worked well enough. It targets overactive immune signaling that drives these diseases.
Conditions it treats include:
- Rheumatoid arthritis (RA) — in adults who didn't respond to TNF blocker medications
- Psoriatic arthritis — in adults and children 2 years and older who didn't respond to TNF blockers
- Atopic dermatitis (eczema) — in people 12 and older whose disease isn't controlled by other systemic therapies
- Ulcerative colitis — in adults who didn't respond to TNF blockers or other approved therapies
- Crohn's disease — in adults who didn't respond to TNF blockers or other approved therapies
Other Drugs & Cannabidivarin (cbdv)
Browse every other medication we’ve checked against Cannabidivarin (cbdv) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Cannabidivarin (cbdv) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Isotretinoin ›
- Tirzepatide ›
- Warfarin Sodium ›
- Ibuprofen ›
- Methamphetamine ›
- Amlodipine Besylate ›
- Docusate ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Tadalafil ›
- Prednisone ›
- Metformin ›
- Semaglutide ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Propranolol ›
- Amphetamine ›
- Amoxicillin ›
- Methotrexate ›
- Levothyroxine, Liothyronine ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Bendamustine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Dextroamphetamine ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Acetaminophen, Aspirin, Caffeine ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Acetaminophen, Codeine ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cannabidivarin (cbdv) list.
Cannabidivarin (cbdv) References
The 4 references that drive our Cannabidivarin (cbdv) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- European Medicines Agency. Public summary of opinion on orphan designation: Cannabidivarin for treatment of fragile X syndrome. Available at: https://www.ema.europa.eu/en/documents/orphan-designation/eu/3/18/1977-public-summary-opinion-orphan-designation-
- US Food and Drug Administration. Orphan Drug Designations and Approvals. Available at: https://www.accessdata.fda.gov/scripts/opdlisting/oopd/. Accessed on March 19, 2021.
- Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
- Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Cannabidivarin (cbdv) and Upadacitinib Hemihydrate Together: Common Questions
Is it safe to take Cannabidivarin (cbdv) with Upadacitinib Hemihydrate?
Do Cannabidivarin (cbdv) and Upadacitinib Hemihydrate have any of the same side effects?
Are Cannabidivarin (cbdv) and Upadacitinib Hemihydrate used for the same thing?
Does Upadacitinib Hemihydrate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.