Drug & supplement interaction

Cannabidivarin (cbdv) + Gabapentin

Gabapentin brand names: Neurontin, Gralise.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Cannabidivarin (cbdv) and Gabapentin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cannabidivarin (cbdv) and Gabapentin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Gabapentin and Cannabidivarin (cbdv) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cannabidivarin (cbdv) at all — not against Gabapentin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cannabidivarin (cbdv) safety at a glance

Cannabidivarin (cb... overall Not established Human safety data are very limited, so long-term effects are not well understood.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Gabapentin and Cannabidivarin (cbdv)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Cannabidivarin (cbdv) and Gabapentin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Unsteadiness / Confusion Worth acting on Additional detail

    Cannabidivarin (cbdv)

    “Orally, cannabidivarin has been associated with dizziness, somnolence, and headache. Ataxia, confusion, and dysarthria have been reported in one patient in a clinical trial who had been taking cannabidivarin 800 mg twice daily for 30 days. This patient also experienced other symptoms of intoxication, including arterial hypotension, nystagmus, diplopia, and elevated liver transaminases.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
    2. 110246. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

    “Orally, arterial hypotension has been reported in one patient in a clinical trial who had been taking cannabidivarin 800 mg twice daily for 30 days. This patient also experienced other symptoms of intoxication, including severe ataxia, nystagmus, diplopia, dysarthria, mild confusion, and elevated liver transaminases.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in hypotension.

    1 source cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed

    Gabapentin

    Listed in the ADVERSE REACTIONS section of the FDA label for Gabapentin. Read the label on DailyMed ›

  • Tremor or shakiness Additional detail

    Cannabidivarin (cbdv)

    Recorded for Cannabidivarin (cbdv) in the same Natural Medicines adverse-effect record shown under Unsteadiness / Confusion above.

    Gabapentin

    Listed in the ADVERSE REACTIONS section of the FDA label for Gabapentin. Read the label on DailyMed ›

  • Drowsiness / Dizziness / Headache reported in 5.0% of FDA reports for Gabapentin Additional detail

    Cannabidivarin (cbdv)

    “There is currently a limited amount of information on the tolerability and adverse effects of oral cannabidivarin.

    Most Common Adverse Effects:

    Orally: Abdominal pain, diarrhea, dizziness, headache, nausea, rash, somnolence.

    Serious Adverse Effects (Rare):

    Orally: Acute kidney failure and elevated liver transaminases at a dose of 800 mg twice daily.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in cluster headache.

    Gabapentin

    Listed in the ADVERSE REACTIONS section of the FDA label for Gabapentin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Diarrhea / Nausea reported in 6.3% of FDA reports for Gabapentin Additional detail

    Cannabidivarin (cbdv)

    “Orally, cannabidivarin has been associated with diarrhea, nausea, and abdominal pain. Drooling has been reported in one child with Rett syndrome.”

    Cannabidivarin (cbdv) · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 107343. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
    2. 110246. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

    Gabapentin

    Listed in the ADVERSE REACTIONS section of the FDA label for Gabapentin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Cannabidivarin (cbdv) but not commonly for Gabapentin: stomach pain, kidney problems, low blood pressure and a skin rash.

Effects for Gabapentin come from the ADVERSE REACTIONS section of its FDA label; effects for Cannabidivarin (cbdv) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 361,481 voluntary FDA FAERS reports for Gabapentin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Gabapentin Is Prescribed For, and What Cannabidivarin (cbdv) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Gabapentin is a prescription medicine with approved uses on its FDA label. Cannabidivarin (cbdv) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Gabapentin is prescribed for: Gabapentin (brands include Neurontin, Relgaabi, Gabarone, Gralise, and Horizant) is primarily used to manage postherpetic neuralgia (PHN) — the nerve pain that lingers after a shingles outbreak — in adults. Neurontin, Relgaabi, Gabarone, and gabapentin capsules, tablets, and oral solution are also used as add-on therapy for partial onset seizures (a type of epilepsy) in adults and children aged 3 and older. Horizant (gabapentin enacarbil extended-release tablet) has two specific approvals: treatment of moderate-to-severe primary restless legs syndrome (RLS) in adults, and management of postherpetic neuralgia in adults. Horizant is not recommended for people who need to sleep during the day and stay awake at night.

Read the rest of what Gabapentin is prescribed for

Gralise is approved only for postherpetic neuralgia and cannot be substituted for other gabapentin products due to its different release profile.

Cannabidivarin (cbdv) has been studied for:

  • Epilepsy studied, not established Cannabidivarin (cbdv) has been studied for this. Natural Medicines rates the evidence: Possibly Ineffective Read what the research shows

    Cannabidivarin (cbdv) for epilepsy

    Oral cannabidivarin does not seem to reduce the incidence of focal seizures.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Gabapentin on your own; if you are taking Cannabidivarin (cbdv) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Cannabidivarin (cbdv) or Gabapentin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cannabidivarin (cbdv) or Gabapentin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Gabapentin

This page covers Cannabidivarin (cbdv) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Gabapentin page lists 106 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 82 moderate · 17 minor.

From our pharmacist’s overview on the Gabapentin page

“Gabapentin (Neurontin, Gralise) calms overactive nerves, which means it already slows your nervous system down, and that is exactly what 78 of the 106 supplements on this list also do. So the dominant risk here is sedation stacked on sedation, extra drowsiness at best and dangerously slowed breathing at worst, and with seven entries ra…”

Reviewed by 2 · Jul 18, 2026

Open the Gabapentin interaction page

How much people look this up

Where Cannabidivarin (cbdv) and Gabapentin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabidivarin (cbdv)
Steady interest

#890 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Gabapentin
Top 5%

#41 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabidivarin (cbdv) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cannabidivarin (cbdv) and Gabapentin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cannabidivarin (cbdv)

What is Cannabidivarin (cbdv)?

  • Epilepsy and seizures
  • Autism spectrum disorder
  • Rett syndrome
  • Fragile X syndrome
  • Nausea
  • Anxiety

Cannabidivarin (CBDV) is a non-intoxicating compound found in cannabis that is being studied mainly for epilepsy and certain neurodevelopmental conditions. The research is still early, mostly from laboratory and animal studies plus small human trials, so it is not an approved or proven treatment. Talk to your pharmacist or doctor before trying any CBDV product.

Cannabaceae · Compound derived from the flowers and leaves of the cannabis plant · Oils, tinctures, isolates, and research-grade formulations

An interaction check asks whether these two react with each other — it does not ask whether Cannabidivarin (cbdv) is a good idea for someone in your situation. Here is what our Cannabidivarin (cbdv) record says about it on its own.

Cannabidivarin (cbdv): dosing

There is no established standard dose for CBDV. The amounts used in research studies were chosen for those specific trials and are not the same as general supplement guidance.If you choose to use a CBDV product, follow the directions on the product label and start low.

From our Cannabidivarin (cbdv) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cannabidivarin (cbdv) monograph & all interactions
Medication

About Gabapentin

What Is Gabapentin Used For?

Brand names: Neurontin, Gralise

Gabapentin (brands include Neurontin, Relgaabi, Gabarone, Gralise, and Horizant) is primarily used to manage postherpetic neuralgia (PHN) — the nerve pain that lingers after a shingles outbreak — in adults. Neurontin, Relgaabi, Gabarone, and gabapentin capsules, tablets, and oral solution are also used as add-on therapy for partial onset seizures (a type of epilepsy) in adults and children aged 3 and older.

Horizant (gabapentin enacarbil extended-release tablet) has two specific approvals: treatment of moderate-to-severe primary restless legs syndrome (RLS) in adults, and management of postherpetic neuralgia in adults. Horizant is not recommended for people who need to sleep during the day and stay awake at night. Gralise is approved only for postherpetic neuralgia and cannot be substituted for other gabapentin products due to its different release profile.

Most-Reported Side Effects for Gabapentin

From FAERS, the FDA’s public side-effect reporting system (361,481 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 24,972 reports
Nausea 22,728 reports
Diarrhea 18,114 reports
Headache 17,897 reports
Dizziness 16,238 reports
See full Gabapentin drug information
Keep checking

Other Drugs & Cannabidivarin (cbdv)

Browse every other medication we’ve checked against Cannabidivarin (cbdv) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cannabidivarin (cbdv) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cannabidivarin (cbdv) list.

See the full Cannabidivarin (cbdv) interactions page
See every supplement checked against Gabapentin, ranked by severity
Evidence & sources

Cannabidivarin (cbdv) References

The 4 references that drive our Cannabidivarin (cbdv) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. European Medicines Agency. Public summary of opinion on orphan designation: Cannabidivarin for treatment of fragile X syndrome. Available at: https://www.ema.europa.eu/en/documents/orphan-designation/eu/3/18/1977-public-summary-opinion-orphan-designation-
  2. US Food and Drug Administration. Orphan Drug Designations and Approvals. Available at: https://www.accessdata.fda.gov/scripts/opdlisting/oopd/. Accessed on March 19, 2021.
  3. Brodie MJ, Czapinski P, Pazdera L, et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures. Cannabis Cannabinoid Res 2021;6(6):528-536. PubMed
  4. Hurley EN, Ellaway CJ, Johnson AM, et al. Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial. Epilepsia 2022;63(7):1736-1747. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cannabidivarin (cbdv) and Gabapentin Together: Common Questions

Is it safe to take Cannabidivarin (cbdv) with Gabapentin?
We do not list a known interaction between Cannabidivarin (cbdv) and Gabapentin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cannabidivarin (cbdv) and Gabapentin have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Cannabidivarin (cbdv) and Gabapentin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Cannabidivarin (cbdv) in each. That is a conversation for your prescriber, especially if Gabapentin is being adjusted to a target.
Does Gabapentin interact with any supplements?
Yes. Gabapentin has documented interactions with 106 supplements in our database — Cannabidivarin (cbdv) is not one of them. The Gabapentin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cannabidivarin (cbdv) monograph Uses, safety profile, and every drug interaction in one place Gabapentin drug information The full plain-English guide to this medication Gabapentin supplement interactions Every supplement checked against Gabapentin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Gabapentin and Cannabidivarin (cbdv)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.