Drug & supplement interaction

Carrot + Chlorpheniramine, Phenylephrine, Phenyltoloxamine

Chlorpheniramine, Phenylephrine, Phenyltoloxamine brand names: Com Time, Q Hist LA, Comhist LA, Linhist LA, Comhist.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Carrot and Chlorpheniramine, Phenylephrine, Phenyltoloxamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Carrot and Chlorpheniramine, Phenylephrine, Phenyltoloxamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chlorpheniramine, Phenylephrine, Phenyltoloxamine and Carrot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Carrot at all — not against Chlorpheniramine, Phenylephrine, Phenyltoloxamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Carrot safety at a glance

Carrot overall Generally safe Carrot as a food is safe for most people; concentrated supplements are less studied.
Pregnancy Likely Safe When used orally in amounts commonly found in food. Carrot essential oil, extracts, and food additives have Generally Recognized as Safe (GRAS) status in the US... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in food. Carrot essential oil, extracts, and food additives have Generally Recognized as Safe (GRAS) status in the US... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chlorpheniramine, Phenylephrine, Phenyltoloxamine and Carrot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Carrot Itself Has Been Linked To

This is not an interaction — nothing below involves Chlorpheniramine, Phenylephrine, Phenyltoloxamine. It is the side-effect record for Carrot on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Carrot, this list is the first place to look. 4 entries are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on Additional detail

    “Compulsive carrot eating is a rare condition in which the patient craves carrots. According to one case report, withdrawal symptoms include nervousness, cravings, insomnia, water brash, and irritability.”

    Carrot · Natural Medicines adverse-effect record, reported in insomnia.

    1 source cited
    1. 25821. Kaplan R. Carrot addiction. Aust N Z J Psychiatry 1996;30(5):698-700.
  • Yellowing of the skin or eyes Worth acting on Additional detail

    “Orally, excessive consumption of carrots or carrot-containing products can cause yellowing of the skin, which results from increased beta-carotene levels in the blood. Carrots may cause allergic reactions in some patients. Allergic responses to carrot-containing foods include skin reactions such as hives, erythema, swelling, and/or papules.”

    Carrot · Natural Medicines adverse-effect record, reported in erythema.

    3 sources cited
    1. 25817. Wetzel WE, Lehn W, Grieb A. [Carotene jaundice in infants with "sugar nursing bottle syndrome"]. Monatsschr Kinderheilkd 1989;137(10):659-61.
    2. 25820. Helbling A. [Food allergy]. Ther Umsch 1994;51(1):31-7.
    3. 96306. Kawai M, Tamagawa-Mineoka R, Hagura A, Masuda K, Katoh N. Allergic contact dermatitis due to carrots. J Dermatol 2014;41(8):753-4. PubMed
  • Wheezing / Hives Worth acting on Additional detail

    “Orally, carrot is well tolerated when consumed as a food. It also seems to be generally well-tolerated when consumed as a medicine. Some people are allergic to carrot; allergic symptoms include anaphylactic, cutaneous, respiratory, and gastrointestinal reactions such as hives, swelling of the larynx, asthma, or diarrhea.”

    Carrot · Natural Medicines adverse-effect record, reported in asthma.

    5 sources cited
    1. 25820. Helbling A. [Food allergy]. Ther Umsch 1994;51(1):31-7.
    2. 93606. Mullins M, Froelke BR, Rivera MR. Effect of delayed activated charcoal on acetaminophen concentration after simulated overdose of oxycodone and acetaminophen. Clin Toxicol (Phila) 2009;47(2):112-5. PubMed
    3. 106560. Sánchez-Guerrero IM, Nieto A, Meseguer J, et al. Occupational Rhinoconjunctivitis Induced by Unusual Allergens of Carrot. J Investig Allergol Clin Immunol 2020;30(3):204-206. PubMed
    4. 25817. Wetzel WE, Lehn W, Grieb A. [Carotene jaundice in infants with "sugar nursing bottle syndrome"]. Monatsschr Kinderheilkd 1989;137(10):659-61.
    5. 101716. Bosanac SS, Clark AK, Sivamani RK. Phytophotodermatitis related to carrot extract-containing sunscreen. Dermatol Online J. 2018;24(1). pii: 13030/qt2nv2d1n0. DOI

    “Orally, carrots may cause allergic reactions in some patients. Allergic responses to carrot-containing foods can include skin reactions such as hives, erythema, swelling, and/or papules. For one patient, treatment of skin lesions resolved after a month of oral antihistamines and topical steroids, and avoiding further contact with carrot.”

    Carrot · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 25820. Helbling A. [Food allergy]. Ther Umsch 1994;51(1):31-7.
    2. 96306. Kawai M, Tamagawa-Mineoka R, Hagura A, Masuda K, Katoh N. Allergic contact dermatitis due to carrots. J Dermatol 2014;41(8):753-4. PubMed
    3. 106560. Sánchez-Guerrero IM, Nieto A, Meseguer J, et al. Occupational Rhinoconjunctivitis Induced by Unusual Allergens of Carrot. J Investig Allergol Clin Immunol 2020;30(3):204-206. PubMed
    4. 101716. Bosanac SS, Clark AK, Sivamani RK. Phytophotodermatitis related to carrot extract-containing sunscreen. Dermatol Online J. 2018;24(1). pii: 13030/qt2nv2d1n0. DOI
  • An allergic reaction Worth acting on Additional detail

    “Orally, carrots may cause allergic reactions in some patients. Allergic responses to carrot-containing foods can include gastrointestinal symptoms, such as diarrhea.”

    Carrot · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 25820. Helbling A. [Food allergy]. Ther Umsch 1994;51(1):31-7.
  • Mood changes or irritability / Anxiety or restlessness / Trouble sleeping Additional detail

    Recorded for Carrot in the same Natural Medicines adverse-effect record shown under Dependence or withdrawal symptoms above.

  • A stuffy or runny nose Additional detail

    Recorded for Carrot in the same Natural Medicines adverse-effect record shown under Wheezing / Hives above.

  • Swelling Additional detail

    Recorded for Carrot in the same Natural Medicines adverse-effect record shown under Wheezing / Hives above.

Showing the 10 most notable of 11 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Carrot — expand a row for the licensed statement it rests on. We haven’t matched Chlorpheniramine, Phenylephrine, Phenyltoloxamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Chlorpheniramine, Phenylephrine, Phenyltoloxamine.

Special populations

Carrot in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in food. Carrot essential oil, extracts, and food additives have Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information available about the safety of carrot when used in medicinal amounts during pregnancy and lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Chlorpheniramine, Phenylephrine, Phenyltoloxamine

This page covers Carrot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorpheniramine, Phenylephrine, Phenyltoloxamine page lists 229 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Henbane (major) and Lithium (major).

By severity: 10 major · 175 moderate · 44 minor.

From our pharmacist’s overview on the Chlorpheniramine, Phenylephrine, Phenyltoloxamine page

“If you take Comhist (chlorpheniramine, phenylephrine, and phenyltoloxamine, a cold and allergy combination), treat its supplement list with real care. Ten of the 229 ingredients on file carry a major rating, and the biggest patterns are worth knowing.”

Reviewed by 2 · Jul 18, 2026

Open the Chlorpheniramine, Phenylephrine, Phenyltoloxamine interaction page

One more smart check

Taking Carrot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,152 real supplement products containing Carrot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Carrot. Even though Carrot itself has no known interaction with Chlorpheniramine, Phenylephrine, Phenyltoloxamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Carrot and Chlorpheniramine, Phenylephrine, Phenyltoloxamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Carrot
Top 5%

#71 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorpheniramine, Phenylephrine, Phenyltoloxamine
Steady interest

#1,448 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Carrot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Carrot and Chlorpheniramine, Phenylephrine, Phenyltoloxamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Carrot

What is Carrot?

  • Source of vitamin A (beta-carotene)
  • Eye and vision health
  • Digestive support
  • Skin health
  • General antioxidant nutrition

Carrot is a common food vegetable that is a rich source of beta-carotene (which the body turns into vitamin A) and other nutrients. Eating carrots is safe and nutritious for most people, but concentrated supplements, seed oil, or large amounts of juice have less evidence and should be used with care. Talk to your pharmacist or doctor before using carrot products for a health condition.

Daucus carota · Apiaceae · Root, seeds, leaves, and seed oil · Whole vegetable, juice, capsules, powders, seed oil, and seed extracts

An interaction check asks whether these two react with each other — it does not ask whether Carrot is a good idea for someone in your situation. Here is what our Carrot record says about it on its own.

Carrot: dosing

There is no official medicinal dose for carrot, because it is mainly a food. As part of a healthy diet, carrots can be enjoyed cooked or raw, or as juice in moderation.For carrot supplements, powders, or seed oil, a standardized effective dose has not been established. If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Carrot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Carrot monograph & all interactions
Keep checking

Other Drugs & Carrot

Browse every other medication we’ve checked against Carrot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Carrot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Carrot list.

See the full Carrot interactions page
See every supplement checked against Chlorpheniramine, Phenylephrine, Phenyltoloxamine, ranked by severity
Evidence & sources

Carrot References

The 14 references that drive our Carrot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Wetzel WE, Lehn W, Grieb A. [Carotene jaundice in infants with "sugar nursing bottle syndrome"]. Monatsschr Kinderheilkd 1989;137(10):659-61.
  3. el-Arab AE, Khalil F, Hussein L. Vitamin A deficiency among preschool children in a rural area of Egypt: the results of dietary assessment and biochemical assay. Int J Food Sci Nutr 2002;53(6):465-74. PubMed
  4. Helbling A. [Food allergy]. Ther Umsch 1994;51(1):31-7.
  5. Kaplan R. Carrot addiction. Aust N Z J Psychiatry 1996;30(5):698-700.
  6. Ncube, T. N., Greiner, T., Malaba, L. C., and Gebre-Medhin, M. Supplementing lactating women with puréed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr 2001;131(5):1497-1502. PubMed
  7. Mullins M, Froelke BR, Rivera MR. Effect of delayed activated charcoal on acetaminophen concentration after simulated overdose of oxycodone and acetaminophen. Clin Toxicol (Phila) 2009;47(2):112-5. PubMed
  8. Kawai M, Tamagawa-Mineoka R, Hagura A, Masuda K, Katoh N. Allergic contact dermatitis due to carrots. J Dermatol 2014;41(8):753-4. PubMed
  9. Xu X, Cheng Y, Li S, et al. Dietary carrot consumption and the risk of prostate cancer. Eur J Nutr 2014;53(8):1615-23. PubMed
  10. Donaldson MS, Speight N, Loomis S. Fibromyalgia syndrome improved using a mostly raw vegetarian diet: an observational study. BMC Complement Altern Med. 2001;1:7. PubMed
  11. Chen H, Shao F, Zhang F, Miao Q. Association between dietary carrot intake and breast cancer: A meta-analysis. Medicine (Baltimore). 2018;97(37):e12164. PubMed
  12. Bosanac SS, Clark AK, Sivamani RK. Phytophotodermatitis related to carrot extract-containing sunscreen. Dermatol Online J. 2018;24(1). pii: 13030/qt2nv2d1n0. DOI
  13. Deding U, Baatrup G, Christensen LP, Kobaek-Larsen M. Carrot Intake and Risk of Colorectal Cancer: A Prospective Cohort Study of 57,053 Danes. Nutrients 2020;12(2):332. PubMed
  14. Sánchez-Guerrero IM, Nieto A, Meseguer J, et al. Occupational Rhinoconjunctivitis Induced by Unusual Allergens of Carrot. J Investig Allergol Clin Immunol 2020;30(3):204-206. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Carrot and Chlorpheniramine, Phenylephrine, Phenyltoloxamine Together: Common Questions

Is it safe to take Carrot with Chlorpheniramine, Phenylephrine, Phenyltoloxamine?
We do not list a known interaction between Carrot and Chlorpheniramine, Phenylephrine, Phenyltoloxamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Chlorpheniramine, Phenylephrine, Phenyltoloxamine interact with any supplements?
Yes. Chlorpheniramine, Phenylephrine, Phenyltoloxamine has documented interactions with 229 supplements in our database — Carrot is not one of them. The Chlorpheniramine, Phenylephrine, Phenyltoloxamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Carrot monograph Uses, safety profile, and every drug interaction in one place Chlorpheniramine, Phenylephrine, Phenyltoloxamine supplement interactions Every supplement checked against Chlorpheniramine, Phenylephrine, Phenyltoloxamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chlorpheniramine, Phenylephrine, Phenyltoloxamine and Carrot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.