Cashew + Pregabalin
Pregabalin brand names: Lyrica, Lyrica CR.
We found no known interaction between Cashew and Pregabalin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Cashew and Pregabalin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pregabalin and Cashew in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cashew safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Pregabalin
Interactions in our licensed database are recorded against drug classes, not just single drug names. Pregabalin is filed under 3 classifications — including cns depressants, oral drugs. Cashew has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Pregabalin’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Cashew Does Interact With Other Medications
Cashew has 86 moderate known drug interactions in our database — Pregabalin isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cashew
We haven’t checked that one against Cashew yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cashew. Pick one to open its full report.
What Pregabalin Is Prescribed For, and What Cashew Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Pregabalin is a prescription medicine with approved uses on its FDA label. Cashew is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Pregabalin is prescribed for: Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury. Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.
Cashew has been studied for:
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Diabetes studied, not established Cashew has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Cashew for diabetes
Clinical research shows that taking cashew nuts 30 grams daily for 12 weeks in addition to a standard diabetic diet reduces systolic blood pressure and increases high-density lipoprotein (HDL) cholesterol by 1.9- and 16-fold more than the diet alone in patients with type 2 diabetes. However, there were no differences in body weight, other blood lipid levels, diastolic blood pressure, or glycemic measures.
3 sources cited
- 101084. Mohan V, Gayathri R, Jaacks LM, et al. Cashew nut consumption increases HDL cholesterol and reduces systolic blood pressure in Asian Indians with Type 2 diabetes: A 12-week randomized controlled trial. J Nutr. 2018;148(1):63-69. PubMed
- 106922. Jalali M, Karamizadeh M, Ferns GA, Zare M, Moosavian SP, Akbarzadeh M. The effects of cashew nut intake on lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2020;50:102387. PubMed
- 106924. Jamshidi S, Moradi Y, Nameni G, Mohsenpour MA, Vafa M. Effects of cashew nut consumption on body composition and glycemic indices: A meta-analysis and systematic review of randomized controlled trials. Diabetes Metab Syndr 2021;15(2):605-613. PubMed
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pregabalin on your own; if you are taking Cashew for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Cashew or Pregabalin
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cashew or Pregabalin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Take Lyrica And Flexeril Together? ›
- Can You Take Gabapentin And Codeine Together? ›
- What Can Cause A Gabapentin False-Positive On A Drug Test? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Pregabalin
This page covers Cashew only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pregabalin page lists 95 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 7 major · 73 moderate · 15 minor.
From our pharmacist’s overview on the Pregabalin page
“Pregabalin (Lyrica) calms overactive nerves, which is how it eases nerve pain, seizures, and anxiety, and that calming action stacks with almost everything on this list. Of the 95 supplements and herbs, the large majority add their own sedation on top of pregabalin's, and a few can tip that into genuine danger, with deep sedation and s…”
Reviewed by 2 · Jul 18, 2026
Taking Cashew as Part of a Dietary Supplement Product? Check It for Interactions
We hold 10 real supplement products containing Cashew, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cashew. Even though Cashew itself has no known interaction with Pregabalin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Cashew and Pregabalin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,198 of 1,452 supplements looked up here in the last 7 days
#38 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cashew reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cashew and Pregabalin records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cashew
What is Cashew?
- Heart health support
- Source of protein and minerals
- Blood sugar support
- Traditional digestive remedy
- Skin and oral care (traditional)
Cashews are a nutritious tree nut that provides protein, healthy fats, fiber, and minerals like magnesium and copper. Eaten as part of a balanced diet, they may support heart health, but evidence for cashew supplements treating any specific disease is limited. People with tree nut allergies must avoid them entirely.
Anacardium occidentale · Anacardiaceae · Nut (seed), nut shell oil, leaves, and bark · Whole nuts, cashew butter, cashew milk, oil, and capsules or extracts
An interaction check asks whether these two react with each other — it does not ask whether Cashew is a good idea for someone in your situation. Here is what our Cashew record says about it on its own.
Cashew: dosing
There is no standardized medicinal dose for cashews. As a food, a typical serving is a small handful of nuts, similar to other nuts. They can be part of a balanced diet for most people.For cashew capsules, extracts, or oils, follow the directions on the product label, since amounts vary by product.
From our Cashew monograph — the full record covers uses, side effects and every documented interaction.
About Pregabalin
What Is Pregabalin Used For?
Brand names: Lyrica, Lyrica CR
Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury.
Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.
Most-Reported Side Effects for Pregabalin
From FAERS, the FDA’s public side-effect reporting system (270,557 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Cashew
Browse every other medication we’ve checked against Cashew — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
86 interactions
- Insulin (rdna) ›
- Glyburide ›
- Insulin (pork) ›
- Insulin (human) ›
- Acarbose ›
- Insulin Glargine ›
- Semaglutide ›
- Chlorpropamide ›
- Exenatide ›
- Glipizide ›
- Glucagon ›
- Insulin Lispro ›
- Metformin ›
- Repaglinide ›
- Sitagliptin ›
- Tirzepatide ›
- Acetohexamide ›
- Albiglutide ›
- Alogliptin ›
- Canagliflozin ›
- Dapagliflozin ›
- Dasiglucagon Hydrochloride ›
- Dulaglutide ›
- Empagliflozin ›
- Ertugliflozin ›
- Exenatide Synthetic ›
- Gliclazide ›
- Glimepiride ›
- Glucose ›
- Inhaled Insulin ›
- Insulin ›
- Insulin (bovine) ›
- Insulin Aspart ›
- Insulin Degludec ›
- Insulin Determir ›
- Insulin Glargine (rdna) ›
- Insulin Glargine Recombinant ›
- Insulin Glulisine (rdna) ›
- Insulin Lispro Recombinant ›
- Insulin Lispro-aabc ›
- Linagliptin ›
- Liraglutide ›
- Liraglutide Recombinant ›
- Lixisenatide ›
- Metformin Hydrochloride ›
- Metformin Xr ›
- Miglitol ›
- Muraglitazar ›
- Nateglinide ›
- Pioglitazone ›
- Pramlintide ›
- Rosiglitazone Maleate ›
- Saxagliptin ›
- Sotagliflozin ›
- Tobutamide ›
- Tolazamide ›
- Tolbutamide ›
- Troglitazone ›
- Vildagliptin ›
- Metformin, Sitagliptin ›
Showing 60 of 86 moderate interactions — see all 86 on the Cashew page.
No interaction 2,743 drugs checked — show the list
We also checked Cashew against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Methamphetamine ›
- Sumatriptan ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Gabapentin ›
- Amphetamine ›
- Acetaminophen, Codeine ›
- Isotretinoin ›
- Azithromycin ›
- Dextroamphetamine ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Cashew list.
Cashew References
The 25 references that drive our Cashew monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Quercia, O., Rafanelli, S., Marsigli, L., Foschi, F. G., and Stefanini, G. F. Unexpected anaphylaxis to cashew nut. Allergy 1999;54(8):895-897. PubMed
- Garcia, F., Moneo, I., Fernandez, B., Garcia-Menaya, J. M., Blanco, J., Juste, S., and Gonzalo. Allergy to Anacardiaceae: description of cashew and pistachio nut allergens. J.Investig.Allergol.Clin.Immunol. 2000;10(3):173-177.
- Criado, R. F., Criado, P. R., Malaman, F., Ensina, L. F., Vasconcellos, C., Aun, W. T., Mello, J. F., and Pires, M. C. Nonoccupational allergic contact dermatitis to cashew nut simulating photosensitivity eczema. Am.J.Contact Dermat. 2002;13(2):85-86. DOI
- Nguyen, A. D. and Gern, J. E. Food allergy masquerading as foreign body obstruction. Ann.Allergy Asthma Immunol. 2003;90(2):271-272. PubMed
- Davoren, M. and Peake, J. Cashew nut allergy is associated with a high risk of anaphylaxis. Arch.Dis.Child 2005;90(10):1084-1085. PubMed
- Schutte, A. E., Van Rooyen, J. M., Huisman, H. W., Mukuddem-Petersen, J., Oosthuizen, W., Hanekom, S. M., and Jerling, J. C. Modulation of baroreflex sensitivity by walnuts versus cashew nuts in subjects with metabolic syndrome. Am.J Hypertens. 2006;19(6 PubMed
- Clark, A. T., Anagnostou, K., and Ewan, P. W. Cashew nut causes more severe reactions than peanut: case-matched comparison in 141 children. Allergy 2007;62(8):913-916. PubMed
- Behl, P. N. Dermatitis from cashew nuts. J.Am.Acad.Dermatol. 1985;12(1 Pt 1):117. PubMed
- Marks, J. G., Jr., DeMelfi, T., McCarthy, M. A., Witte, E. J., Castagnoli, N., Epstein, W. L., and Aber, R. C. Dermatitis from cashew nuts. J.Am.Acad.Dermatol. 1984;10(4):627-631. PubMed
- Rosen, T. and Fordice, D. B. Cashew nut dermatitis. South.Med.J. 1994;87(4):543-546. PubMed
- Hamilton, T. K. and Zug, K. A. Systemic contact dermatitis to raw cashew nuts in a pesto sauce. Am.J Contact Dermat. 1998;9(1):51-54. DOI
- Stock AK, Colzato L, Beste C. On the effects of tyrosine supplementation on interference control in a randomized, double-blind placebo-control trial. Eur Neuropsychopharmacol. 2018;28(8):933-944. PubMed
- Baer DJ, Novotny JA. Consumption of cashew nuts does not influence blood lipids or other markers of cardiovascular disease in humans: a randomized controlled trial. Am J Clin Nutr. 2019;109(2):269-275. PubMed
- Mohan V, Gayathri R, Jaacks LM, et al. Cashew nut consumption increases HDL cholesterol and reduces systolic blood pressure in Asian Indians with Type 2 diabetes: A 12-week randomized controlled trial. J Nutr. 2018;148(1):63-69. PubMed
- Mah E, Schulz JA, Kaden VN, et al. Cashew consumption reduces total and LDL cholesterol: a randomized, crossover, controlled-feeding trial. Am J Clin Nutr. 2017;105(5):1070-1078. PubMed
- Bernardino M, Parmar MS. Oxalate nephropathy from cashew nut intake. CMAJ. 2017;189(10):E405-E408. PubMed
- Moyses-Neto M, Brito BRS, de Araújo Brito DJ, et al. Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report. BMC Nephrol. 2018;19(1):265. PubMed
- Bastiaan-Net S, Reitsma M, Cordewener JHG, et al. IgE cross-reactivity of cashew nut allergens. Int Arch Allergy Immunol. 2019;178(1):19-32. PubMed
- Brandström J, Lilja G, Nilsson C, et al. IgE to novel citrus seed allergens among cashew-allergic children. Pediatr Allergy Immunol. 2016;27(5):550-3. PubMed
- Jalali M, Karamizadeh M, Ferns GA, Zare M, Moosavian SP, Akbarzadeh M. The effects of cashew nut intake on lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2020;50:102387. PubMed
- Jamshidi S, Moradi Y, Nameni G, Mohsenpour MA, Vafa M. Effects of cashew nut consumption on body composition and glycemic indices: A meta-analysis and systematic review of randomized controlled trials. Diabetes Metab Syndr 2021;15(2):605-613. PubMed
- Costa MAC, Hermsdorff HHM, Caldas APS, et al. Acute consumption of a shake containing cashew and Brazil nuts did not affect appetite in overweight subjects: a randomized, cross-over study. Eur J Nutr 2021;60(8):4321-4330. PubMed
- Lee O, Park K, Sun K, O'Shea JP, Gordon S. Cashew-Induced Oxalate Nephropathy: A Rare Cause of Acute Renal Failure. Mil Med 2021;usab453. PubMed
- Baresic M, Bosnic D, Bakula M, Zarkovic K. Eosinophilia-myalgia syndrome induced by excessive L-tryptophan intake from cashew nuts. Cent Eur J Med 2014;9(6):796-801. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Cashew and Pregabalin Together: Common Questions
Is it safe to take Cashew with Pregabalin?
Do Cashew and Pregabalin have any of the same side effects?
Are Cashew and Pregabalin used for the same thing?
How was the Cashew and Pregabalin combination checked?
Does Cashew interact with any other medications?
Does Pregabalin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.