Drug & supplement interaction

Cashew + Trastuzumab-Pkrb

Trastuzumab-Pkrb brand name: Herzuma.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Cashew and Trastuzumab-Pkrb in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cashew and Trastuzumab-Pkrb

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trastuzumab-Pkrb and Cashew in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cashew safety at a glance

Cashew overall Generally safe Cashews are safe as a food for most people, but those with tree nut allergies must avoid them.
Pregnancy Use caution Cashews are generally fine as a food in pregnancy, but concentrated supplements or extracts have not been well studied.
Breastfeeding Use caution Eating cashews as food is usually fine, but supplement-strength products lack safety data while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trastuzumab-Pkrb and Cashew? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Cashew Does Interact With Other Medications

Cashew has 86 moderate known drug interactions in our database — Trastuzumab-Pkrb isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Trastuzumab-Pkrb)
Taking anything else?

Check Another of Your Medications Against Cashew

Covers the 2,830 medications we’ve checked against Cashew. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cashew and Trastuzumab-Pkrb May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Cashew

    “Orally, there are numerous reports of cashew nut allergy. Symptoms have included asthma, hives, swelling, wheezing, gastrointestinal symptoms, and shortness of breath.

    Topically, contact with cashew can lead to redness and nodule and blister formation. Alkyl phenols contained in the cashew nut shell are strong skin irritants, similar to alkyl phenols found in poison ivy, poison oak, mango, and ginkgo.”

    Cashew · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 40106. Quercia, O., Rafanelli, S., Marsigli, L., Foschi, F. G., and Stefanini, G. F. Unexpected anaphylaxis to cashew nut. Allergy 1999;54(8):895-897. PubMed
    2. 40109. Garcia, F., Moneo, I., Fernandez, B., Garcia-Menaya, J. M., Blanco, J., Juste, S., and Gonzalo. Allergy to Anacardiaceae: description of cashew and pistachio nut allergens. J.Investig.Allergol.Clin.Immunol. 2000;10(3):173-177.
    3. 40123. Nguyen, A. D. and Gern, J. E. Food allergy masquerading as foreign body obstruction. Ann.Allergy Asthma Immunol. 2003;90(2):271-272. PubMed
    4. 40131. Davoren, M. and Peake, J. Cashew nut allergy is associated with a high risk of anaphylaxis. Arch.Dis.Child 2005;90(10):1084-1085. PubMed
    5. 40135. Clark, A. T., Anagnostou, K., and Ewan, P. W. Cashew nut causes more severe reactions than peanut: case-matched comparison in 141 children. Allergy 2007;62(8):913-916. PubMed
    6. 101082. Stock AK, Colzato L, Beste C. On the effects of tyrosine supplementation on interference control in a randomized, double-blind placebo-control trial. Eur Neuropsychopharmacol. 2018;28(8):933-944. PubMed

    Trastuzumab-Pkrb

    Listed in the ADVERSE REACTIONS section of the FDA label for Trastuzumab-Pkrb. Read the label on DailyMed ›

  • Weight loss / Muscle pain Additional detail

    Cashew

    “Orally, consumption of large amounts of cashew nuts (approximately 200 grams daily for over 6 months) is thought to be responsible for the development of eosinophilia-myalgia syndrome (EMS) in a 59-year-old adult who consumed large amounts of cashew for its supposed weight loss effects.”

    Cashew · Natural Medicines adverse-effect record, reported in myalgia.

    1 source cited
    1. 106927. Baresic M, Bosnic D, Bakula M, Zarkovic K. Eosinophilia-myalgia syndrome induced by excessive L-tryptophan intake from cashew nuts. Cent Eur J Med 2014;9(6):796-801. PubMed

    Trastuzumab-Pkrb

    Listed in the ADVERSE REACTIONS section of the FDA label for Trastuzumab-Pkrb. Read the label on DailyMed ›

  • Joint pain Additional detail

    Cashew

    “Orally, cashew nuts may cause constipation, bloating, weight gain, fatigue and feelings of malaise, or worsening joint pain in some patients, but these side effects are rare. Very large intakes of the cashew nut or pseudofruit have resulted in oxalate nephropathy in case reports.

    Orally and topically, cashew nut can cause allergic responses in some patients.”

    Cashew · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 101085. Mah E, Schulz JA, Kaden VN, et al. Cashew consumption reduces total and LDL cholesterol: a randomized, crossover, controlled-feeding trial. Am J Clin Nutr. 2017;105(5):1070-1078. PubMed
    2. 101086. Bernardino M, Parmar MS. Oxalate nephropathy from cashew nut intake. CMAJ. 2017;189(10):E405-E408. PubMed
    3. 101087. Moyses-Neto M, Brito BRS, de Araújo Brito DJ, et al. Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report. BMC Nephrol. 2018;19(1):265. PubMed
    4. 106926. Lee O, Park K, Sun K, O'Shea JP, Gordon S. Cashew-Induced Oxalate Nephropathy: A Rare Cause of Acute Renal Failure. Mil Med 2021;usab453. PubMed
    5. 40106. Quercia, O., Rafanelli, S., Marsigli, L., Foschi, F. G., and Stefanini, G. F. Unexpected anaphylaxis to cashew nut. Allergy 1999;54(8):895-897. PubMed
    6. 40109. Garcia, F., Moneo, I., Fernandez, B., Garcia-Menaya, J. M., Blanco, J., Juste, S., and Gonzalo. Allergy to Anacardiaceae: description of cashew and pistachio nut allergens. J.Investig.Allergol.Clin.Immunol. 2000;10(3):173-177.

    “Orally, adverse effects possibly or probably related to cashew nuts have included cases of worsened arthritis and gout. However, these side effects are rare.”

    Cashew · Natural Medicines adverse-effect record, reported in gout.

    1 source cited
    1. 101085. Mah E, Schulz JA, Kaden VN, et al. Cashew consumption reduces total and LDL cholesterol: a randomized, crossover, controlled-feeding trial. Am J Clin Nutr. 2017;105(5):1070-1078. PubMed

    Trastuzumab-Pkrb

    Listed in the ADVERSE REACTIONS section of the FDA label for Trastuzumab-Pkrb. Read the label on DailyMed ›

  • Constipation Additional detail

    Cashew

    “Orally, adverse effects possibly or probably related to cashew nuts have included cases of constipation and bloating. However, these side effects are rare.”

    Cashew · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 101085. Mah E, Schulz JA, Kaden VN, et al. Cashew consumption reduces total and LDL cholesterol: a randomized, crossover, controlled-feeding trial. Am J Clin Nutr. 2017;105(5):1070-1078. PubMed

    Trastuzumab-Pkrb

    Listed in the ADVERSE REACTIONS section of the FDA label for Trastuzumab-Pkrb. Read the label on DailyMed ›

  • Swelling Additional detail

    Cashew

    Recorded for Cashew in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

    Trastuzumab-Pkrb

    Listed in the ADVERSE REACTIONS section of the FDA label for Trastuzumab-Pkrb. Read the label on DailyMed ›

  • Tiredness Additional detail

    Cashew

    “Orally, adverse effects possibly or probably related to cashew nuts have included cases of fatigue and general malaise. However, these side effects are rare.”

    Cashew · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 101085. Mah E, Schulz JA, Kaden VN, et al. Cashew consumption reduces total and LDL cholesterol: a randomized, crossover, controlled-feeding trial. Am J Clin Nutr. 2017;105(5):1070-1078. PubMed

    Trastuzumab-Pkrb

    Listed in the ADVERSE REACTIONS section of the FDA label for Trastuzumab-Pkrb. Read the label on DailyMed ›

Reported for Cashew but not commonly for Trastuzumab-Pkrb: weight gain, bloating or gas, wheezing and hives.

Effects for Trastuzumab-Pkrb come from the ADVERSE REACTIONS section of its FDA label; effects for Cashew come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

One more smart check

Taking Cashew as Part of a Dietary Supplement Product? Check It for Interactions

We hold 10 real supplement products containing Cashew, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cashew. Even though Cashew itself has no known interaction with Trastuzumab-Pkrb, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cashew and Trastuzumab-Pkrb Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cashew
Steady interest

#1,195 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trastuzumab-Pkrb
Steady interest

#2,471 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cashew reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cashew and Trastuzumab-Pkrb records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cashew

What is Cashew?

Cashew
  • Heart health support
  • Source of protein and minerals
  • Blood sugar support
  • Traditional digestive remedy
  • Skin and oral care (traditional)

Cashews are a nutritious tree nut that provides protein, healthy fats, fiber, and minerals like magnesium and copper. Eaten as part of a balanced diet, they may support heart health, but evidence for cashew supplements treating any specific disease is limited. People with tree nut allergies must avoid them entirely.

Anacardium occidentale · Anacardiaceae · Nut (seed), nut shell oil, leaves, and bark · Whole nuts, cashew butter, cashew milk, oil, and capsules or extracts

An interaction check asks whether these two react with each other — it does not ask whether Cashew is a good idea for someone in your situation. Here is what our Cashew record says about it on its own.

Cashew: dosing

There is no standardized medicinal dose for cashews. As a food, a typical serving is a small handful of nuts, similar to other nuts. They can be part of a balanced diet for most people.For cashew capsules, extracts, or oils, follow the directions on the product label, since amounts vary by product.

From our Cashew monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cashew monograph & all interactions
Keep checking

Other Drugs & Cashew

Browse every other medication we’ve checked against Cashew — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Cashew page.

No interaction 2,743 drugs checked — show the list

We also checked Cashew against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Cashew list.

See the full Cashew interactions page
See every supplement checked against Trastuzumab-Pkrb, ranked by severity
Evidence & sources

Cashew References

The 25 references that drive our Cashew monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Quercia, O., Rafanelli, S., Marsigli, L., Foschi, F. G., and Stefanini, G. F. Unexpected anaphylaxis to cashew nut. Allergy 1999;54(8):895-897. PubMed
  3. Garcia, F., Moneo, I., Fernandez, B., Garcia-Menaya, J. M., Blanco, J., Juste, S., and Gonzalo. Allergy to Anacardiaceae: description of cashew and pistachio nut allergens. J.Investig.Allergol.Clin.Immunol. 2000;10(3):173-177.
  4. Criado, R. F., Criado, P. R., Malaman, F., Ensina, L. F., Vasconcellos, C., Aun, W. T., Mello, J. F., and Pires, M. C. Nonoccupational allergic contact dermatitis to cashew nut simulating photosensitivity eczema. Am.J.Contact Dermat. 2002;13(2):85-86. DOI
  5. Nguyen, A. D. and Gern, J. E. Food allergy masquerading as foreign body obstruction. Ann.Allergy Asthma Immunol. 2003;90(2):271-272. PubMed
  6. Davoren, M. and Peake, J. Cashew nut allergy is associated with a high risk of anaphylaxis. Arch.Dis.Child 2005;90(10):1084-1085. PubMed
  7. Schutte, A. E., Van Rooyen, J. M., Huisman, H. W., Mukuddem-Petersen, J., Oosthuizen, W., Hanekom, S. M., and Jerling, J. C. Modulation of baroreflex sensitivity by walnuts versus cashew nuts in subjects with metabolic syndrome. Am.J Hypertens. 2006;19(6 PubMed
  8. Clark, A. T., Anagnostou, K., and Ewan, P. W. Cashew nut causes more severe reactions than peanut: case-matched comparison in 141 children. Allergy 2007;62(8):913-916. PubMed
  9. Behl, P. N. Dermatitis from cashew nuts. J.Am.Acad.Dermatol. 1985;12(1 Pt 1):117. PubMed
  10. Marks, J. G., Jr., DeMelfi, T., McCarthy, M. A., Witte, E. J., Castagnoli, N., Epstein, W. L., and Aber, R. C. Dermatitis from cashew nuts. J.Am.Acad.Dermatol. 1984;10(4):627-631. PubMed
  11. Rosen, T. and Fordice, D. B. Cashew nut dermatitis. South.Med.J. 1994;87(4):543-546. PubMed
  12. Hamilton, T. K. and Zug, K. A. Systemic contact dermatitis to raw cashew nuts in a pesto sauce. Am.J Contact Dermat. 1998;9(1):51-54. DOI
  13. Stock AK, Colzato L, Beste C. On the effects of tyrosine supplementation on interference control in a randomized, double-blind placebo-control trial. Eur Neuropsychopharmacol. 2018;28(8):933-944. PubMed
  14. Baer DJ, Novotny JA. Consumption of cashew nuts does not influence blood lipids or other markers of cardiovascular disease in humans: a randomized controlled trial. Am J Clin Nutr. 2019;109(2):269-275. PubMed
  15. Mohan V, Gayathri R, Jaacks LM, et al. Cashew nut consumption increases HDL cholesterol and reduces systolic blood pressure in Asian Indians with Type 2 diabetes: A 12-week randomized controlled trial. J Nutr. 2018;148(1):63-69. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cashew and Trastuzumab-Pkrb Together: Common Questions

Is it safe to take Cashew with Trastuzumab-Pkrb?
We do not list a known interaction between Cashew and Trastuzumab-Pkrb. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cashew and Trastuzumab-Pkrb have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Cashew interact with any other medications?
Yes. Cashew has 86 documented drug interactions in our database — Trastuzumab-Pkrb is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cashew monograph Uses, safety profile, and every drug interaction in one place Trastuzumab-Pkrb supplement interactions Every supplement checked against Trastuzumab-Pkrb, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 25 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trastuzumab-Pkrb and Cashew?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.