Drug & supplement interaction

Chrysanthemum + Pramlintide

Pramlintide brand name: Symlin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chrysanthemum and Pramlintide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chrysanthemum and Pramlintide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pramlintide and Chrysanthemum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chrysanthemum at all — not against Pramlintide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chrysanthemum safety at a glance

Chrysanthemum overall Use caution Generally well tolerated as a tea, but it can cause allergic reactions in sensitive people.
Pregnancy Avoid Safety during pregnancy has not been established, so it is best avoided unless your doctor approves.
Breastfeeding Avoid There is not enough reliable information on safety while breastfeeding, so caution or avoidance is wise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pramlintide and Chrysanthemum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Chrysanthemum and Pramlintide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Chrysanthemum

    “Topically and via occupational exposure, chrysanthemum can cause allergic reactions. Chrysanthemum allergy symptoms can include urticaria, contact dermatitis, eczema, actinic reticuloid photosensitivity dermatitis, pollinosis, rhinoconjunctivitis, and asthma. There are numerous case reports and studies showing that allergies to Chrysanthemum are very common, with an estimated 60% of Europeans being allergic.”

    Chrysanthemum · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 5552. Kuno Y, Kawabe Y, Sakakibara S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40:224-5. PubMed
    2. 5554. deJong NW, Vermeulen AM, van Wijik RG, deGroot H. Occupational allergy caused by flowers. Allergy 1998;53:204-9. PubMed
    3. 5556. Camplimi P, Sertoli A, Fabbri P, Panconesi E. Alantolactone sensitivity in chrysanthemum contact dermatitis. Contact Dermatitis 1978;4:93-102. PubMed
    4. 5557. Bleumink E, Mitchell JC, Geismann TA, Towers GH. Contact hypersensitivity to sesquiterpene lactones in Chrysanthemum dermatitis. Contact Dermatitis 1976;2:81-8.
    5. 6958. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
    6. 42842. Kuno, Y., Kawabe, Y., and Sakakibara, S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40(4):224-225. PubMed

    Pramlintide

    Listed in the ADVERSE REACTIONS section of the FDA label for Pramlintide. Read the label on DailyMed ›

Reported for Chrysanthemum but not commonly for Pramlintide: sun sensitivity, a skin rash, hives and wheezing.

Effects for Pramlintide come from the ADVERSE REACTIONS section of its FDA label; effects for Chrysanthemum come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 102 voluntary FDA FAERS reports for Pramlintide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Pramlintide Is Prescribed For, and What Chrysanthemum Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Pramlintide is a prescription medicine with approved uses on its FDA label. Chrysanthemum is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Pramlintide is prescribed for: SymlinPen (pramlintide) is used as an add-on treatment for adults with type 1 or type 2 diabetes who already use mealtime insulin but still haven't reached their target blood sugar levels — even with optimal insulin therapy. It is not a replacement for insulin. It works alongside insulin, given right before major meals, to reduce the spike in blood sugar that happens after eating.

Chrysanthemum has been studied for:

  • Stroke studied, not established Chrysanthemum has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Chrysanthemum for stroke

    It is unclear if oral chrysanthemum is beneficial in patients with stroke.

  • Diabetes studied, not established Chrysanthemum has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Chrysanthemum for diabetes

    Although there has been interest in using oral chrysanthemum for diabetes, there is insufficient reliable information about the clinical effects of chrysanthemum for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pramlintide on your own; if you are taking Chrysanthemum for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Pramlintide

This page covers Chrysanthemum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pramlintide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Pramlintide page

“The single entry rated major on the pramlintide (Symlin) list is Siberian cocklebur, which has caused severe hypoglycemia in humans, not just in lab studies. That matters more than usual here because pramlintide is injected at mealtimes alongside insulin, and a dangerous low is already the main hazard of that pairing.”

Reviewed by 2 · Jul 18, 2026

Open the Pramlintide interaction page

One more smart check

Taking Chrysanthemum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 28 real supplement products containing Chrysanthemum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysanthemum. Even though Chrysanthemum itself has no known interaction with Pramlintide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysanthemum and Pramlintide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysanthemum
Steady interest

#1,053 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pramlintide
Steady interest

#1,791 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chrysanthemum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chrysanthemum and Pramlintide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chrysanthemum

What is Chrysanthemum?

  • Eye irritation and tired eyes
  • Cooling and 'heat-clearing' in traditional Chinese medicine
  • Cold and flu symptoms
  • Headache
  • Soothing/relaxation
  • High blood pressure (traditional use)

Chrysanthemum flowers are most often used as a soothing tea in traditional Chinese medicine and as a folk remedy for eye irritation, colds, and minor inflammation. Solid human evidence for these uses is limited, so it should be seen as a pleasant traditional drink rather than a proven treatment. People allergic to ragweed and related plants, and those who are pregnant or breastfeeding, should be cautious and talk to a pharmacist or doctor first.

Chrysanthemum morifolium · Asteraceae · Flowers (dried flower heads) · Tea, dried flowers, capsules, extracts, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Chrysanthemum is a good idea for someone in your situation. Here is what our Chrysanthemum record says about it on its own.

Chrysanthemum: dosing

There is no official standardized dose for chrysanthemum. It is most often used as a tea made from dried flowers, and supplement strength varies widely between products.If you choose to use it, follow the directions on the product label and start with a small amount to see how you react.

From our Chrysanthemum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chrysanthemum monograph & all interactions
Medication

About Pramlintide Injection

What Is Pramlintide Injection Used For?

Brand name: Symlin

SymlinPen (pramlintide) is used as an add-on treatment for adults with type 1 or type 2 diabetes who already use mealtime insulin but still haven't reached their target blood sugar levels — even with optimal insulin therapy.

It is not a replacement for insulin. It works alongside insulin, given right before major meals, to reduce the spike in blood sugar that happens after eating.

See full Pramlintide Injection drug information
Keep checking

Other Drugs & Chrysanthemum

Browse every other medication we’ve checked against Chrysanthemum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chrysanthemum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chrysanthemum list.

See the full Chrysanthemum interactions page
See every supplement checked against Pramlintide, ranked by severity
Evidence & sources

Chrysanthemum References

The 25 references that drive our Chrysanthemum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kuno Y, Kawabe Y, Sakakibara S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40:224-5. PubMed
  2. deJong NW, Vermeulen AM, van Wijik RG, deGroot H. Occupational allergy caused by flowers. Allergy 1998;53:204-9. PubMed
  3. Camplimi P, Sertoli A, Fabbri P, Panconesi E. Alantolactone sensitivity in chrysanthemum contact dermatitis. Contact Dermatitis 1978;4:93-102. PubMed
  4. Bleumink E, Mitchell JC, Geismann TA, Towers GH. Contact hypersensitivity to sesquiterpene lactones in Chrysanthemum dermatitis. Contact Dermatitis 1976;2:81-8.
  5. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  6. Hausen BM. The sensitizing capacity of Compositae plants. III. Test results and cross-reactions in Compositae-sensitive patients. Dermatologica 1979;159:1-11. DOI
  7. Kuno, Y., Kawabe, Y., and Sakakibara, S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40(4):224-225. PubMed
  8. Schulz, K. H., Hausen, B. M., Wallhofer, L., and Schmidt-Loffler, P. Chrysanthemum allergy. Pt. II: Experimental studies on the causative agents. Arch.Dermatol.Forsch. 1975;251(3):235-244.
  9. Singhal, V. and Reddy, B. S. Common contact sensitizers in Delhi. J Dermatol 2000;27(7):440-445. PubMed
  10. Kuroume, T., Todokoro, M., Tomidokoro, H., Kanbe, Y., and Matsumura, T. Chrysanthemum pollinosis in Japan. Int.Arch.Allergy Appl.Immunol. 1975;48(6):800-811.
  11. Groenewoud, G. C., de Jong, N. W., Burdorf, A., de Groot, H., and van Wyk, R. G. Prevalence of occupational allergy to Chrysanthemum pollen in greenhouses in the Netherlands. Allergy 2002;57(9):835-840.
  12. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  13. Hashimoto, Y., Kawada, A., Aragane, Y., and Tezuka, T. Occupational contact dermatitis from chrysanthemum in a mortician. Contact Dermatitis 2003;49(2):106-107. PubMed
  14. Groenewoud, G. C., de Groot, H., and van Wijk, R. G. Impact of occupational and inhalant allergy on rhinitis-specific quality of life in employees of bell pepper greenhouses in the Netherlands. Ann Allergy Asthma Immunol 2006;96(1):92-97. PubMed
  15. Sharma, S. C. and Kaur, S. Airborne contact dermatitis from Compositae plants in northern India. Contact Dermatitis 1989;21(1):1-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chrysanthemum and Pramlintide Together: Common Questions

Is it safe to take Chrysanthemum with Pramlintide?
We do not list a known interaction between Chrysanthemum and Pramlintide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chrysanthemum and Pramlintide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Chrysanthemum and Pramlintide used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Chrysanthemum in each. That is a conversation for your prescriber, especially if Pramlintide is being adjusted to a target.
Does Pramlintide interact with any supplements?
Yes. Pramlintide has documented interactions with 239 supplements in our database — Chrysanthemum is not one of them. The Pramlintide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chrysanthemum monograph Uses, safety profile, and every drug interaction in one place Pramlintide Injection drug information The full plain-English guide to this medication Pramlintide supplement interactions Every supplement checked against Pramlintide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 25 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pramlintide and Chrysanthemum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.