Citicoline + Lenalidomide
Lenalidomide brand name: Revlimid.
We found no known interaction between Citicoline and Lenalidomide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Citicoline and Lenalidomide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lenalidomide and Citicoline in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Citicoline at all — not against Lenalidomide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Citicoline safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Lenalidomide
This page covers Citicoline only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lenalidomide page lists 70 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate) and Andrographis (moderate).
By severity: 1 major · 59 moderate · 10 minor.
From our pharmacist’s overview on the Lenalidomide page
“People taking lenalidomide (Revlimid) for multiple myeloma are often drawn to immune-boosting supplements, which is exactly why this list deserves genuine care. Fifty-three of its 70 entries are herbs and mushrooms thought to stimulate the immune system, astragalus, ginseng, and beta-glucans among them, and each could theoretically pus…”
Reviewed by 2 · Jul 18, 2026
Taking Citicoline as Part of a Dietary Supplement Product? Check It for Interactions
We hold 464 real supplement products containing Citicoline, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Citicoline. Even though Citicoline itself has no known interaction with Lenalidomide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Citicoline and Lenalidomide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#311 of 1,452 supplements looked up here in the last 7 days
#247 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Citicoline reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Citicoline and Lenalidomide records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Citicoline
What is Citicoline?
- Memory and thinking
- Brain health and aging
- Stroke recovery support
- Focus and attention
- Eye health (glaucoma)
Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken for memory, focus, and brain aging, and some research is promising, but high-quality evidence is still limited for most uses. It is generally well tolerated, but you should talk with your pharmacist or doctor before starting it.
Not applicable (a compound the body makes naturally) · Capsules, tablets, powder, sometimes liquid
An interaction check asks whether these two react with each other — it does not ask whether Citicoline is a good idea for someone in your situation. Here is what our Citicoline record says about it on its own.
Citicoline: dosing
There is no official standard dose of citicoline for supplement use. Doses used in research have varied widely depending on the condition being studied.The safest approach is to follow the directions on the product label and not exceed the recommended amount.
From our Citicoline monograph — the full record covers uses, side effects and every documented interaction.
About Lenalidomide
What Is Lenalidomide Used For?
Brand name: Revlimid
Lenalidomide capsules (brand names Revlimid and Lenalidomide) are used to treat several blood cancers and related conditions in adults. These include multiple myeloma (MM) — both in combination with dexamethasone and as maintenance therapy after a stem cell transplant — and transfusion-dependent anemia caused by low- or intermediate-1-risk myelodysplastic syndromes (MDS) linked to a specific chromosome change called deletion 5q.
Lenalidomide capsules are also used for mantle cell lymphoma (MCL) that has come back or stopped responding after at least two prior treatments (one of which included bortezomib). In combination with a rituximab product, they treat previously treated follicular lymphoma (FL) and previously treated marginal zone lymphoma (MZL). Lenalidomide is not approved for chronic lymphocytic leukemia (CLL) outside of clinical trials.
Most-Reported Side Effects for Lenalidomide
From FAERS, the FDA’s public side-effect reporting system (420,080 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Citicoline
Browse every other medication we’ve checked against Citicoline — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Citicoline against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Methamphetamine ›
- Tirzepatide ›
- Ibuprofen ›
- Docusate ›
- Tadalafil ›
- Warfarin Sodium ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Isotretinoin ›
- Prednisone ›
- Semaglutide ›
- Lisdexamfetamine ›
- Metformin ›
- Propranolol ›
- Amitriptyline ›
- Methotrexate ›
- Amlodipine Besylate ›
- Amoxicillin ›
- Lisinopril ›
- Amphetamine ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Bendamustine ›
- Pregabalin ›
- Lamotrigine ›
- Acyclovir ›
- Azithromycin ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Dextroamphetamine ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Acetaminophen, Codeine ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Citicoline list.
Citicoline References
The 11 references that drive our Citicoline monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
- Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
- Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
- Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
- Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
- Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
- Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
- Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
- Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
- Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
- Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Citicoline and Lenalidomide Together: Common Questions
Is it safe to take Citicoline with Lenalidomide?
Do Citicoline and Lenalidomide have any of the same side effects?
Does Lenalidomide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.