Drug & supplement interaction

Clematis Recta + Acetaminophen, Butalbital, Caffeine

Acetaminophen, Butalbital, Caffeine brand names: Tecnal, Esgic Plus, Fiogesic, Triad, Repan, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Clematis Recta and Acetaminophen, Butalbital, Caffeine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Clematis Recta and Acetaminophen, Butalbital, Caffeine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Acetaminophen, Butalbital, Caffeine and Clematis Recta in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Clematis Recta at all — not against Acetaminophen, Butalbital, Caffeine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Clematis Recta safety at a glance

Clematis Recta overall Use caution The raw plant is toxic and irritating; only highly diluted homeopathic forms are generally considered low-risk.
Pregnancy Likely Unsafe When the fresh plant is used orally. There is insufficient reliable information available for the safety of the dried plant; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When the fresh plant is used orally. There is insufficient reliable information available for the safety of the dried plant; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Acetaminophen, Butalbital, Caffeine and Clematis Recta? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Clematis Recta Itself Has Been Linked To

This is not an interaction — nothing below involves Acetaminophen, Butalbital, Caffeine. It is the side-effect record for Clematis Recta on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Clematis Recta, this list is the first place to look.

  • Diarrhea Additional detail

    “Orally, fresh Clematis recta can cause colic, diarrhea, and severe irritation to the gastrointestinal tract (18).”

    Clematis Recta · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Clematis Recta — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Acetaminophen, Butalbital, Caffeine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Acetaminophen, Butalbital, Caffeine column appears here.

Special populations

Clematis Recta in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When the fresh plant is used orally. There is insufficient reliable information available for the safety of the dried plant; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Butalbital, Caffeine

This page covers Clematis Recta only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Butalbital, Caffeine page lists 252 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).

By severity: 11 major · 197 moderate · 44 minor.

From our pharmacist’s overview on the Acetaminophen, Butalbital, Caffeine page

“Alcohol is the interaction I would flag first for anyone taking acetaminophen, butalbital, and caffeine (Esgic, Fiogesic, and others). Drinking raises the risk of liver injury from the acetaminophen component, and 38 of the 252 supplement ingredients on file carry that same liver concern.”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Butalbital, Caffeine interaction page

How much people look this up

Where Clematis Recta and Acetaminophen, Butalbital, Caffeine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Clematis Recta
Steady interest

#951 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Butalbital, Caffeine
Top 5%

#65 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Clematis Recta reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Clematis Recta and Acetaminophen, Butalbital, Caffeine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Clematis Recta

What is Clematis Recta?

  • Skin complaints and eruptions
  • Swollen or tender lymph glands
  • Urinary discomfort
  • Nerve pain
  • Men's groin and testicular discomfort (traditional homeopathic use)

Clematis recta is a flowering plant in the buttercup family that is mostly sold today as a homeopathic remedy. The fresh plant is toxic and irritating, and there is no reliable human evidence that it treats any condition, so it should be used cautiously and only under professional guidance.

Clematis recta · Ranunculaceae · Fresh leaves and stems (aerial parts), usually gathered before flowering · Homeopathic pellets, dilutions, and mother tinctures; rarely as topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Clematis Recta is a good idea for someone in your situation. Here is what our Clematis Recta record says about it on its own.

Clematis Recta: dosing

There is no established standard dose for Clematis recta. The raw plant is not recommended at all because it is toxic and irritating.When sold as a homeopathic remedy, it comes in standardized dilutions and potencies set by the manufacturer.

From our Clematis Recta monograph — the full record covers uses, side effects and every documented interaction.

Read the full Clematis Recta monograph & all interactions
Medication

About Acetaminophen, Butalbital, and Caffeine

What Is Acetaminophen, Butalbital, and Caffeine Used For?

Brand names: Tecnal, Esgic Plus, Fiogesic, Triad, Repan, Esgic, Fioricet

This combination product — available as capsules, tablets, and oral solution under various names including Fioricet — is used to relieve the symptoms of tension headaches (also called muscle contraction headaches).

All supported products, including Fioricet capsules and the oral solution, share this same indication. Because butalbital can be habit-forming, extended or repeated use is not recommended, and these products are not established as safe or effective for treating headaches that come back frequently over time.

See full Acetaminophen, Butalbital, and Caffeine drug information
Keep checking

Other Drugs & Clematis Recta

Browse every other medication we’ve checked against Clematis Recta — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Clematis Recta against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Clematis Recta list.

See the full Clematis Recta interactions page
See every supplement checked against Acetaminophen, Butalbital, Caffeine, ranked by severity
Evidence & sources

Clematis Recta References

The 1 references that drive our Clematis Recta monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Clematis Recta and Acetaminophen, Butalbital, Caffeine Together: Common Questions

Is it safe to take Clematis Recta with Acetaminophen, Butalbital, Caffeine?
We do not list a known interaction between Clematis Recta and Acetaminophen, Butalbital, Caffeine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Acetaminophen, Butalbital, Caffeine interact with any supplements?
Yes. Acetaminophen, Butalbital, Caffeine has documented interactions with 252 supplements in our database — Clematis Recta is not one of them. The Acetaminophen, Butalbital, Caffeine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Clematis Recta monograph Uses, safety profile, and every drug interaction in one place Acetaminophen, Butalbital, and Caffeine drug information The full plain-English guide to this medication Acetaminophen, Butalbital, Caffeine supplement interactions Every supplement checked against Acetaminophen, Butalbital, Caffeine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Acetaminophen, Butalbital, Caffeine and Clematis Recta?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.