Drug & supplement interaction

Codonopsis + Dapagliflozin Propanediol, Saxagliptin Hydrochloride

Dapagliflozin Propanediol, Saxagliptin Hydrochloride brand name: Qtern.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Codonopsis has a moderate interaction with Dapagliflozin Propanediol, Saxagliptin Hydrochloride. Theoretically, codonopsis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Codonopsis and Dapagliflozin Propanediol, Saxagliptin Hydrochloride

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Dapagliflozin Propanediol, Saxagliptin Hydrochloride

Dapagliflozin Propanediol, Saxagliptin Hydrochloride falls under ANTIDIABETES DRUGS — the group Codonopsis interacts with.

Theoretically, codonopsis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Laboratory and animal research suggest that codonopsis has antidiabetic effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Qtern combines two diabetes medicines, dapagliflozin and saxagliptin, that both work to lower your blood sugar. Here's the thing with codonopsis: in lab dishes and animal studies, this root has shown some blood-sugar-lowering activity of its own. So the worry is simple addition. If codonopsis nudges your sugar down a little and Qtern is already doing the heavy lifting, you could theoretically dip too low.

I want to be honest with you, though, that this concern comes only from early research, not from people, so it's far from certain. Still, it's worth knowing the signs of low blood sugar: shakiness, sweating, dizziness, a fast heartbeat, or feeling confused. If you'd like to try codonopsis, please run it by your pharmacist or doctor first and keep an eye on your sugar readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Jia W, Bi Q, Jiang S, et al. Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS. Food Funct 2022;13(5):2456-2464.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Codonopsis Also Interacts With Other Medications

Codonopsis has 210 moderate known drug interactions in our database — the Dapagliflozin Propanediol, Saxagliptin Hydrochloride one above is one of them. If you take anything else, check it against the full list below.

Moderate 210 No known interaction 2,620 (incl. Dapagliflozin Propanediol, Saxagliptin Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Codonopsis

Covers the 2,830 medications we’ve checked against Codonopsis. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dapagliflozin Propanediol, Saxagliptin Hydrochloride

This page covers Codonopsis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dapagliflozin Propanediol, Saxagliptin Hydrochloride page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

Open the Dapagliflozin Propanediol, Saxagliptin Hydrochloride interaction page

One more smart check

Taking Codonopsis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 493 real supplement products containing Codonopsis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Codonopsis. Your product may carry other ingredients that interact with Dapagliflozin Propanediol, Saxagliptin Hydrochloride too, on top of Codonopsis — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Codonopsis and Dapagliflozin Propanediol, Saxagliptin Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Codonopsis
Top 25%

#258 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dapagliflozin Propanediol, Saxagliptin Hydrochloride
Steady interest

#2,237 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Codonopsis

What is Codonopsis?

  • Fatigue and low energy
  • Digestive support and poor appetite
  • Immune support
  • General tonic ('qi' tonic in Traditional Chinese Medicine)
  • Cough and weakness during recovery from illness

Codonopsis (often called 'dang shen') is a root long used in Traditional Chinese Medicine as a gentle energy and digestive tonic, frequently as a milder substitute for ginseng. Human research is very limited, so its benefits are not well proven. It appears reasonably well tolerated in food-like amounts, but you should talk with a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.

Read the full Codonopsis monograph & all interactions
Keep checking

Other Drugs & Codonopsis

Browse every other medication we’ve checked against Codonopsis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
210Moderate
0Minor
2,619No known interaction
210 Moderate 2,619 No interaction
Moderate

210 interactions

Showing 60 of 210 moderate interactions — see all 210 on the Codonopsis page.

No interaction 2,619 drugs checked — show the list

We also checked Codonopsis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,619 medications checked with no known interaction — see the full Codonopsis list.

See the full Codonopsis interactions page
See every supplement checked against Dapagliflozin Propanediol, Saxagliptin Hydrochloride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Codonopsis monograph › Uses, safety, and every drug interaction in one place Dapagliflozin Propanediol, Saxagliptin Hydrochloride supplement interactions › Every supplement checked against Dapagliflozin Propanediol, Saxagliptin Hydrochloride, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Codonopsis and Dapagliflozin Propanediol, Saxagliptin Hydrochloride Together: Common Questions

Can you take Codonopsis with Dapagliflozin Propanediol, Saxagliptin Hydrochloride?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Codonopsis and Dapagliflozin Propanediol, Saxagliptin Hydrochloride interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dapagliflozin Propanediol, Saxagliptin Hydrochloride and Codonopsis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.