Drug & supplement interaction

Codonopsis + Potassium Chloride (prescription drug)

Potassium Chloride (prescription drug) brand names: Kaon-Cl, Klor-Con, Micro-K, K-Tab, Slow K, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Codonopsis and Potassium Chloride (prescription drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Potassium Chloride (prescription drug) states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Codonopsis and Potassium Chloride (prescription drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Potassium Chloride (prescription drug) and Codonopsis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Codonopsis safety at a glance

Codonopsis overall Use caution Generally considered well tolerated in traditional food-like amounts, but high-quality safety data are limited.
Pregnancy Avoid Not enough reliable safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it unless your doctor advises otherwise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Potassium Chloride (prescription drug) and Codonopsis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Potassium Chloride (prescription drug)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Potassium Chloride (prescription drug) is filed under a single classification — oral drugs. Codonopsis has documented interactions with 3 drug classes — the most serious being abiraterone (zytiga) (moderate), anticoagulant/antiplatelet drugs (moderate) and antidiabetes drugs (moderate) — and none of Potassium Chloride (prescription drug)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Codonopsis Does Interact With Other Medications

Codonopsis has 211 moderate known drug interactions in our database — Potassium Chloride (prescription drug) isn’t one of them. If you take anything else, check it against the full list below.

Moderate 211 No known interaction 2,619 (incl. Potassium Chloride (prescription drug))
Taking anything else?

Check Another of Your Medications Against Codonopsis

Covers the 2,830 medications we’ve checked against Codonopsis. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Codonopsis and Potassium Chloride (prescription drug) May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Chest pain Worth acting on Additional detail

    Codonopsis

    “Orally, very large doses of codonopsis (30-60 grams) may cause chest pain or arrhythmia (12).”

    Codonopsis · Natural Medicines adverse-effect record, reported in arrhythmia.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Potassium Chloride (prescription drug)

    Listed in the ADVERSE REACTIONS section of the FDA label for Potassium Chloride (prescription drug). Read the label on DailyMed ›

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    Codonopsis

    “Orally, codonopsis can cause allergic reactions including anaphylaxis and urticaria. In one case report, an 18-year-old male developed anaphylaxis after ingesting codonopsis roots. In an oral re-challenge test, he developed anaphylaxis and urticaria again 30 minutes after consuming 20 grams of codonopsis root.”

    Codonopsis · Natural Medicines adverse-effect record, reported in urticaria.

    1 source cited
    1. 100060. Hur GY, Choi GS, Park HJ, Ye YM, Park HS. Anaphylactic shock induced by Codonopsis lanceolata, traditional Chinese medicine in a patient with allergic rhinitis. Allergy. 2008;63(10):1406-7.

    Potassium Chloride (prescription drug)

    Listed in the ADVERSE REACTIONS section of the FDA label for Potassium Chloride (prescription drug). Read the label on DailyMed ›

Reported for Codonopsis but not commonly for Potassium Chloride (prescription drug): unsteadiness, an irregular heartbeat, dizziness and confusion.

Effects for Potassium Chloride (prescription drug) come from the ADVERSE REACTIONS section of its FDA label; effects for Codonopsis come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Potassium Chloride (prescription drug) Products Have a Food Rule — Codonopsis Should Not Break It

At least one FDA label for a product containing Potassium Chloride (prescription drug) says to take it with food. If you take Codonopsis on an empty stomach out of habit, keep them separate — and take Potassium Chloride (prescription drug) with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Potassium Chloride (prescription drug) products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Severe Hypocitraturia In patients with severe hypocitraturia (urinary citrate < 150 mg/day), therapy should be initiated at a dosage of 60 mEq/day (30 mEq two times/day or 20 mEq three times/day with meals or within 30 minutes after meals or bedtime snack).

From the Dosage and Administration section of the FDA label we read for Potassium Chloride (prescription drug) — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Codonopsis or Potassium Chloride (prescription drug)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Codonopsis or Potassium Chloride (prescription drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Potassium Chloride (prescription drug)

This page covers Codonopsis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Potassium Chloride (prescription drug) page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Potassium Chloride (prescription drug) interaction page

One more smart check

Taking Codonopsis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 493 real supplement products containing Codonopsis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Codonopsis. Even though Codonopsis itself has no known interaction with Potassium Chloride (prescription drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Codonopsis and Potassium Chloride (prescription drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Codonopsis
Top 25%

#263 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Potassium Chloride (prescription drug)
Steady interest

#2,638 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Codonopsis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Codonopsis and Potassium Chloride (prescription drug) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Codonopsis

What is Codonopsis?

  • Fatigue and low energy
  • Digestive support and poor appetite
  • Immune support
  • General tonic ('qi' tonic in Traditional Chinese Medicine)
  • Cough and weakness during recovery from illness

Codonopsis (often called 'dang shen') is a root long used in Traditional Chinese Medicine as a gentle energy and digestive tonic, frequently as a milder substitute for ginseng. Human research is very limited, so its benefits are not well proven. It appears reasonably well tolerated in food-like amounts, but you should talk with a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.

Codonopsis pilosula · Campanulaceae · Dried root · Dried root, slices, decoctions (teas/soups), powders, capsules, tinctures, and herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Codonopsis is a good idea for someone in your situation. Here is what our Codonopsis record says about it on its own.

Codonopsis: dosing

There is no official, standardized dose of Codonopsis. Traditional preparations often use the dried root in soups or decoctions, while commercial products come as capsules, powders, and tinctures in widely varying strengths.Follow the directions on your specific product label, and do not assume more is better. A pharmacist or doctor can help you decide whether it is appropriate for you and what amount may be reasonable.

From our Codonopsis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Codonopsis monograph & all interactions
Medication

About Potassium

What Is Potassium Used For?

Brand names: Kaon-Cl, Klor-Con, Micro-K, K-Tab, Slow K, K-Tab ER, K-Dur, Micro-K 10, K-Norm, Klotrix, K-Lease

Potassium chloride products — available as oral tablets, capsules, liquids, powders, and intravenous injection — are used to treat or prevent hypokalemia (low potassium in the blood), with or without metabolic alkalosis (an acid-base imbalance). This includes patients on diuretics, those with certain heart rhythm problems, liver disease with fluid buildup, or conditions that cause potassium loss. The IV form is reserved for when oral treatment is not possible.

Potassium citrate tablets (including the brand Urocit-K) are used for a different purpose: managing kidney stone conditions, specifically renal tubular acidosis (RTA) with calcium stones, hypocitraturic calcium oxalate nephrolithiasis (low-citrate kidney stones), and uric acid kidney stones with or without calcium stones. Extended-release oral capsules and tablets of potassium chloride are specifically reserved for patients who cannot tolerate or comply with liquid or effervescent forms.

See full Potassium drug information
Keep checking

Other Drugs & Codonopsis

Browse every other medication we’ve checked against Codonopsis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
211Moderate
0Minor
2,618No known interaction
211 Moderate 2,618 No interaction
Moderate

211 interactions

Showing 60 of 211 moderate interactions — see all 211 on the Codonopsis page.

No interaction 2,618 drugs checked — show the list

We also checked Codonopsis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,618 medications checked with no known interaction — see the full Codonopsis list.

See the full Codonopsis interactions page
See every supplement checked against Potassium Chloride (prescription drug), ranked by severity
Evidence & sources

Codonopsis References

The 5 references that drive our Codonopsis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Xu, X., Wang, S. R., and Lin, Q. [Clinical and experimental study on codonopsis pilosula oral liquor in treating coronary heart disease with blood stasis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(7):398-400.
  3. Hur GY, Choi GS, Park HJ, Ye YM, Park HS. Anaphylactic shock induced by Codonopsis lanceolata, traditional Chinese medicine in a patient with allergic rhinitis. Allergy. 2008;63(10):1406-7.
  4. Zhang ZB, Ip SP, Cho WCS, et al. Herb-drug interactions between androgenic Chinese herbal medicines and androgen receptor antagonist on tumor growth: Studies on two xenograft prostate cancer animal models. Phytother Res. 2021.
  5. Jia W, Bi Q, Jiang S, et al. Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS. Food Funct 2022;13(5):2456-2464.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Codonopsis and Potassium Chloride (prescription drug) Together: Common Questions

Is it safe to take Codonopsis with Potassium Chloride (prescription drug)?
We do not list a known interaction between Codonopsis and Potassium Chloride (prescription drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Codonopsis and Potassium Chloride (prescription drug) have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Codonopsis and Potassium Chloride (prescription drug) at the same time of day?
At least one FDA label for a product containing Potassium Chloride (prescription drug) says to take it with food. If you take Codonopsis on an empty stomach out of habit, keep them separate and take Potassium Chloride (prescription drug) with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Potassium Chloride (prescription drug) products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Codonopsis and Potassium Chloride (prescription drug) combination checked?
Interactions in our licensed database are recorded against drug classes. Potassium Chloride (prescription drug) is filed under 1 classification, and Codonopsis has documented interactions with 3 drug classes — none of Potassium Chloride (prescription drug)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Codonopsis interact with any other medications?
Yes. Codonopsis has 211 documented drug interactions in our database — Potassium Chloride (prescription drug) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Potassium Chloride (prescription drug) interact with any supplements?
Yes. Potassium Chloride (prescription drug) has documented interactions with 17 supplements in our database — Codonopsis is not one of them. The Potassium Chloride (prescription drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Codonopsis monograph Uses, safety profile, and every drug interaction in one place Potassium drug information The full plain-English guide to this medication Potassium Chloride (prescription drug) supplement interactions Every supplement checked against Potassium Chloride (prescription drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Potassium Chloride (prescription drug) and Codonopsis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.