Drug & supplement interaction

Corkwood Tree + Isotretinoin

Isotretinoin brand names: Accutane, Amnesteem, Claravis, Sotret, Absorica, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Corkwood Tree and Isotretinoin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Corkwood Tree and Isotretinoin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isotretinoin and Corkwood Tree in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Corkwood Tree safety at a glance

Corkwood Tree overall Avoid The plant contains potent toxic tropane alkaloids and is not safe for self-use.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isotretinoin and Corkwood Tree? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Isotretinoin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Isotretinoin is filed under 4 classifications — including retinoids, cytochrome p450 2c8 (cyp2c8) substrates, photosensitizing drugs. Corkwood Tree has documented interactions with 1 drug class — the most serious being anticholinergic drugs (moderate) — and none of Isotretinoin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Corkwood Tree Does Interact With Other Medications

Corkwood Tree has 195 moderate known drug interactions in our database — Isotretinoin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 195 No known interaction 2,635 (incl. Isotretinoin)
Taking anything else?

Check Another of Your Medications Against Corkwood Tree

Covers the 2,830 medications we’ve checked against Corkwood Tree. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Corkwood Tree and Isotretinoin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on Additional detail

    Corkwood Tree

    “Orally, corkwood tree leaves can cause agitation, delirium, and hallucinations. In one case, a 22-year-old male presented with agitation, delirium, and visual hallucinations, among other symptoms, after ingesting 5-10 corkwood tree leaves. Alkaloid constituents in corkwood tree, namely scopolamine and atropine, have anticholinergic effects, which likely explains these adverse psychiatric effects.”

    Corkwood Tree · Natural Medicines adverse-effect record, reported in delirium.

    1 source cited
    1. 106659. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.

    Isotretinoin

    Listed in the ADVERSE REACTIONS section of the FDA label for Isotretinoin. Read the label on DailyMed ›

  • Raised blood pressure Worth acting on Additional detail

    Corkwood Tree

    “Orally, corkwood tree leaves can cause hypertension and tachycardia. In one case, a 22-year-old male presented with hypertension and tachycardia, among other symptoms, after ingesting 5-10 corkwood tree leaves. Alkaloid constituents in corkwood tree, namely scopolamine and atropine, have anticholinergic effects, which likely explains these adverse cardiovascular effects.”

    Corkwood Tree · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 106659. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.

    Isotretinoin

    Listed in the ADVERSE REACTIONS section of the FDA label for Isotretinoin. Read the label on DailyMed ›

  • Flushing Additional detail

    Corkwood Tree

    “Orally, corkwood tree leaves can cause flushing, hyperthermia, and anhidrosis. In one case, a 22-year-old male presented with flushing and hyperthermia, among other symptoms, after ingesting 5-10 corkwood tree leaves. Anhidrosis, or the inability to sweat normally, has also been observed with corkwood tree leaf use.”

    Corkwood Tree · Natural Medicines adverse-effect record, reported in niacin-induced flushing.

    1 source cited
    1. 106659. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.

    Isotretinoin

    Listed in the ADVERSE REACTIONS section of the FDA label for Isotretinoin. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Corkwood Tree

    Recorded for Corkwood Tree in the same Natural Medicines adverse-effect record shown under Hallucinations above.

    Isotretinoin

    Listed in the ADVERSE REACTIONS section of the FDA label for Isotretinoin. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Corkwood Tree

    Recorded for Corkwood Tree in the same Natural Medicines adverse-effect record shown under Hallucinations above.

    Isotretinoin

    Listed in the ADVERSE REACTIONS section of the FDA label for Isotretinoin. Read the label on DailyMed ›

Reported for Corkwood Tree but not commonly for Isotretinoin: trouble passing urine, dry mouth and confusion.

Effects for Isotretinoin come from the ADVERSE REACTIONS section of its FDA label; effects for Corkwood Tree come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 46,523 voluntary FDA FAERS reports for Isotretinoin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Corkwood Tree in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Corkwood Tree or Isotretinoin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Corkwood Tree or Isotretinoin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Isotretinoin

This page covers Corkwood Tree only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isotretinoin page lists 49 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Vitamin A (major), African Wild Potato (moderate), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 2 major · 35 moderate · 12 minor.

From our pharmacist’s overview on the Isotretinoin page

“Vitamin A is the first thing anyone on isotretinoin (Accutane, Absorica, Claravis) should check their supplements for, because isotretinoin is itself a vitamin A derivative and stacking more on top can push levels into toxic range. It is one of two major-rated entries among the 49 supplements and herbs known to interact with this acne…”

Reviewed by 2 · Jul 18, 2026

Open the Isotretinoin interaction page

How much people look this up

Where Corkwood Tree and Isotretinoin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corkwood Tree
Steady interest

#1,263 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isotretinoin
Top 1%

#29 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Corkwood Tree reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Corkwood Tree and Isotretinoin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Corkwood Tree

What is Corkwood Tree?

  • Source of scopolamine and hyoscyamine alkaloids
  • Traditional use as a stimulant or for fatigue
  • Historic use for motion sickness (via its alkaloids)
  • Antispasmodic / smooth muscle effects

Corkwood Tree (Duboisia myoporoides) is an Australian plant best known as a commercial source of powerful tropane alkaloids like scopolamine and hyoscyamine, not as a safe home remedy. The raw plant is highly toxic and should not be used as a dietary supplement; only purified, medically prescribed alkaloids derived from it should be used, and only under a doctor's care.

Duboisia myoporoides · Solanaceae · Leaves · Not commonly sold as a consumer supplement; historically a source of plant extracts and isolated alkaloids

An interaction check asks whether these two react with each other — it does not ask whether Corkwood Tree is a good idea for someone in your situation. Here is what our Corkwood Tree record says about it on its own.

Corkwood Tree: dosing

There is no safe established dose of Corkwood Tree leaf for self-use, and it should not be taken as a supplement. The only appropriate use of compounds from this plant is in standardized, prescription medicines (such as scopolamine or hyoscyamine) that are dosed and monitored by healthcare professionals.If you have been given a medicine derived from this plant, follow the product label and your prescriber's directions exactly. Do not attempt to make or use any homemade preparation.

From our Corkwood Tree monograph — the full record covers uses, side effects and every documented interaction.

Read the full Corkwood Tree monograph & all interactions
Medication

About Isotretinoin

What Is Isotretinoin Used For?

Brand names: Accutane, Amnesteem, Claravis, Sotret, Absorica, Roaccutane

Isotretinoin capsules — sold under brand names including Absorica, Absorica LD, Accutane, Amnesteem, Claravis, and others — are indicated for the treatment of severe recalcitrant nodular acne in non-pregnant patients 12 years of age and older. This means deep, inflamed acne nodules (5 mm or larger) that have not cleared with conventional treatments, including systemic antibiotics.

This medication is reserved for the most severe cases because of its significant potential side effects. It is not used for mild or moderate acne. Absorica and Absorica LD are two distinct products that are not interchangeable with each other on a milligram-per-milligram basis due to differences in bioavailability and recommended dosing.

Most-Reported Side Effects for Isotretinoin

From FAERS, the FDA’s public side-effect reporting system (46,523 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 5,609 reports
Inflammatory bowel disease 5,250 reports
Colitis ulcerative 3,800 reports
Dry skin 2,326 reports
Pregnancy 2,080 reports
See full Isotretinoin drug information
Keep checking

Other Drugs & Corkwood Tree

Browse every other medication we’ve checked against Corkwood Tree — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
195Moderate
0Minor
2,634No known interaction
195 Moderate 2,634 No interaction
Moderate

195 interactions

Showing 60 of 195 moderate interactions — see all 195 on the Corkwood Tree page.

No interaction 2,634 drugs checked — show the list

We also checked Corkwood Tree against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,634 medications checked with no known interaction — see the full Corkwood Tree list.

See the full Corkwood Tree interactions page
See every supplement checked against Isotretinoin, ranked by severity
Evidence & sources

Corkwood Tree References

The 2 references that drive our Corkwood Tree monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Pellowe E, Poncia HD. Duboisia ingestion: an unusual cause of anticholinergic poisoning. Emerg Med Australas 2013;25(3):268-70.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Corkwood Tree and Isotretinoin Together: Common Questions

Is it safe to take Corkwood Tree with Isotretinoin?
We do not list a known interaction between Corkwood Tree and Isotretinoin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Corkwood Tree and Isotretinoin have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Corkwood Tree and Isotretinoin combination checked?
Interactions in our licensed database are recorded against drug classes. Isotretinoin is filed under 4 classifications, and Corkwood Tree has documented interactions with 1 drug class — none of Isotretinoin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Corkwood Tree interact with any other medications?
Yes. Corkwood Tree has 195 documented drug interactions in our database — Isotretinoin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Isotretinoin interact with any supplements?
Yes. Isotretinoin has documented interactions with 49 supplements in our database — Corkwood Tree is not one of them. The Isotretinoin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Corkwood Tree monograph Uses, safety profile, and every drug interaction in one place Isotretinoin drug information The full plain-English guide to this medication Isotretinoin supplement interactions Every supplement checked against Isotretinoin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isotretinoin and Corkwood Tree?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.