Drug & supplement interaction

Daffodil + Cobimetinib Fumarate

Cobimetinib Fumarate brand name: Cotellic.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Daffodil and Cobimetinib Fumarate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Daffodil and Cobimetinib Fumarate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cobimetinib Fumarate and Daffodil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Daffodil at all — not against Cobimetinib Fumarate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Daffodil safety at a glance

Daffodil overall Avoid All parts of the daffodil are toxic and should not be eaten or used as a homemade supplement.
Pregnancy Likely Unsafe When used orally or topically; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or topically; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cobimetinib Fumarate and Daffodil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Daffodil and Cobimetinib Fumarate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Swelling / Diarrhea / Vomiting Additional detail

    Daffodil

    “Daffodil is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity.

    Serious Adverse Effects (Rare):

    Orally: Irritation and swelling of the mouth, tongue, and throat, and sudden onset of vomiting, diarrhea, and abdominal pain. Large doses have also been reported to cause blurred vision, coma, convulsions, dizziness, headache, hypotension, salivation, sweating, and tremors.”

    Daffodil · Natural Medicines adverse-effect record, reported in cluster headache.

    “Orally, daffodil can cause irritation and swelling of the mouth, tongue, and throat, as well as sudden onset of vomiting, diarrhea, and abdominal pain. Vomiting and diarrhea often limit the progression of symptoms, and adults typically recover within 3-4 hours. Large doses of daffodil can cause toxicity, including excessive salivation (18,19,101223).”

    Daffodil · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
    3. 101223. Matulkova P, Gobin M, Evans M, et al. Gastro-intestinal poisoning due to consumption of daffodils mistaken for vegetables at commercial markets, Bristol, United Kingdom. Clin Toxicol (Phila) 2012;50(8):788-90. doi: 10.3109/15563650.2012.718350. PubMed

    Cobimetinib Fumarate

    Listed in the ADVERSE REACTIONS section of the FDA label for Cobimetinib Fumarate. Read the label on DailyMed ›

  • A skin rash Additional detail

    Daffodil

    “Topically, skin contact with any part of the daffodil plant can cause dermatitis, sometimes referred to as "daffodil itch" or "lily rash" (18,5004,5005).

    Orally, large doses of daffodil can cause toxicity, including excessive sweating.”

    Daffodil · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 5004. Bruynzeel DP. Bulb dermatitis. Dermatological problems in the flower bulb industries. Contact Dermatitis 1997;37:70-7.
    3. 5005. Bruynzeel DP, de Boer EM, Brouwer EJ, et al. Dermatitis in bulb growers. Contact Dermatitis 1993;29:11-5. PubMed
    4. 101223. Matulkova P, Gobin M, Evans M, et al. Gastro-intestinal poisoning due to consumption of daffodils mistaken for vegetables at commercial markets, Bristol, United Kingdom. Clin Toxicol (Phila) 2012;50(8):788-90. doi: 10.3109/15563650.2012.718350. PubMed

    Cobimetinib Fumarate

    Listed in the ADVERSE REACTIONS section of the FDA label for Cobimetinib Fumarate. Read the label on DailyMed ›

Reported for Daffodil but not commonly for Cobimetinib Fumarate: sweating, stomach pain, blurred vision and seizures.

Effects for Cobimetinib Fumarate come from the ADVERSE REACTIONS section of its FDA label; effects for Daffodil come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Daffodil in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally or topically; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Daffodil or Cobimetinib Fumarate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Daffodil or Cobimetinib Fumarate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Cobimetinib Fumarate

This page covers Daffodil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cobimetinib Fumarate page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Cobimetinib Fumarate page

“If you are on cobimetinib (Cotellic) for melanoma, be strict about supplements, because this list carries real weight. The drug is cleared by the liver enzyme CYP3A4, and nearly all 138 flagged ingredients can push its blood level up or down through that pathway.”

Reviewed by 2 · Jul 18, 2026

Open the Cobimetinib Fumarate interaction page

How much people look this up

Where Daffodil and Cobimetinib Fumarate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Daffodil
Top half

#504 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cobimetinib Fumarate
Steady interest

#2,027 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Daffodil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Daffodil and Cobimetinib Fumarate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Daffodil

What is Daffodil?

  • Traditional anti-inflammatory remedy
  • Folk use for tumors and skin growths
  • Source of galantamine for memory/Alzheimer's
  • Antimicrobial folk use
  • Topical traditional remedies

Daffodil is a beautiful but toxic plant that contains alkaloids, including the one used to make the Alzheimer's drug galantamine. It is not safe to take as a homemade supplement, and all parts of the plant—especially the bulb—can cause serious poisoning if eaten. Leave any medicinal use to standardized, regulated medications prescribed by a doctor.

Narcissus pseudonarcissus · Amaryllidaceae · Bulb, flower, and leaves (source of certain alkaloids) · Not commonly available as a consumer supplement; the plant is the source of the prescription drug galantamine

An interaction check asks whether these two react with each other — it does not ask whether Daffodil is a good idea for someone in your situation. Here is what our Daffodil record says about it on its own.

Daffodil: dosing

There is no safe established dose of daffodil as a supplement, and it should not be taken by mouth. Because the whole plant is toxic, no amount can be recommended for self-treatment.The only proven medical use linked to this plant is the prescription drug galantamine, which is manufactured to a precise, standardized dose and must be prescribed and monitored by a healthcare provider.

From our Daffodil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Daffodil monograph & all interactions
Medication

About Cobimetinib

What Is Cobimetinib Used For?

Brand name: Cotellic

Cobimetinib is approved for two uses in adults. First, it is used in combination with another drug called vemurafenib to treat melanoma (a type of skin cancer) that cannot be surgically removed or has spread to other parts of the body — but only when the tumor carries a specific genetic change called a BRAF V600E or V600K mutation. A lab test must confirm this mutation before treatment begins.

Second, cobimetinib can be used on its own (as a single agent) to treat adults with histiocytic neoplasms — a rare group of cancers involving immune cells called histiocytes.

See full Cobimetinib drug information
Keep checking

Other Drugs & Daffodil

Browse every other medication we’ve checked against Daffodil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Daffodil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Daffodil list.

See the full Daffodil interactions page
See every supplement checked against Cobimetinib Fumarate, ranked by severity
Evidence & sources

Daffodil References

The 5 references that drive our Daffodil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bruynzeel DP. Bulb dermatitis. Dermatological problems in the flower bulb industries. Contact Dermatitis 1997;37:70-7.
  4. Bruynzeel DP, de Boer EM, Brouwer EJ, et al. Dermatitis in bulb growers. Contact Dermatitis 1993;29:11-5. PubMed
  5. Matulkova P, Gobin M, Evans M, et al. Gastro-intestinal poisoning due to consumption of daffodils mistaken for vegetables at commercial markets, Bristol, United Kingdom. Clin Toxicol (Phila) 2012;50(8):788-90. doi: 10.3109/15563650.2012.718350. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Daffodil and Cobimetinib Fumarate Together: Common Questions

Is it safe to take Daffodil with Cobimetinib Fumarate?
We do not list a known interaction between Daffodil and Cobimetinib Fumarate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Daffodil and Cobimetinib Fumarate have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Cobimetinib Fumarate interact with any supplements?
Yes. Cobimetinib Fumarate has documented interactions with 138 supplements in our database — Daffodil is not one of them. The Cobimetinib Fumarate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Daffodil monograph Uses, safety profile, and every drug interaction in one place Cobimetinib drug information The full plain-English guide to this medication Cobimetinib Fumarate supplement interactions Every supplement checked against Cobimetinib Fumarate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cobimetinib Fumarate and Daffodil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.