Diatomaceous Earth + Pegloticase
Pegloticase brand name: Krystexxa.
We found no known interaction between Diatomaceous Earth and Pegloticase in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Diatomaceous Earth and Pegloticase
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pegloticase and Diatomaceous Earth in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Diatomaceous Earth at all — not against Pegloticase, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Diatomaceous Earth safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Pegloticase
This page covers Diatomaceous Earth only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pegloticase page lists 1 supplement it has a documented interaction with, worst first, each one explained.
The most serious there right now: Inosine (moderate).
By severity: 1 moderate.
From our pharmacist’s overview on the Pegloticase page
“Inosine is the one supplement on record that can work against pegloticase (Krystexxa), the IV enzyme infused for severe gout that has stopped responding to standard treatment. Inosine raises uric acid in the blood and urine, which is precisely what pegloticase exists to lower, so combining the two could blunt the very benefit those inf…”
Reviewed by 2 · Jul 18, 2026
Where Diatomaceous Earth and Pegloticase Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,284 of 1,452 supplements looked up here in the last 7 days
#2,628 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Diatomaceous Earth reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Diatomaceous Earth and Pegloticase records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Diatomaceous Earth
What is Diatomaceous Earth?
- Digestive cleansing or 'detox'
- Intestinal parasite support
- Skin, hair, and nail health (silica)
- Cholesterol support
- Toxin or heavy metal binding
Diatomaceous earth is a fine powder made from the fossilized shells of tiny algae called diatoms. Only food-grade diatomaceous earth should ever be swallowed, and human evidence for its health claims (detox, parasites, cholesterol) is very limited. Never inhale the dust, and talk to a pharmacist or doctor before taking it.
Fossilized remains of diatoms (a type of algae) · Food-grade powder, capsules, mixed into water or smoothies
An interaction check asks whether these two react with each other — it does not ask whether Diatomaceous Earth is a good idea for someone in your situation. Here is what our Diatomaceous Earth record says about it on its own.
Diatomaceous Earth: dosing
There is no official, standardized dose of diatomaceous earth, and it is not approved as a medicine. Amounts vary widely between products and brands.If you choose to use it, follow the directions on a clearly labeled food-grade product, start low, and drink plenty of water.
From our Diatomaceous Earth monograph — the full record covers uses, side effects and every documented interaction.
About Pegloticase Injection
What Is Pegloticase Injection Used For?
Brand name: Krystexxa
Krystexxa is used to treat chronic gout in adults whose gout has not responded to conventional treatments — either because standard uric-acid-lowering medications (like xanthine oxidase inhibitors) haven't brought uric acid to a normal level, or because those drugs cannot be used.
Krystexxa is not recommended for people who have high uric acid levels but no gout symptoms (a condition called asymptomatic hyperuricemia).
Most-Reported Side Effects for Pegloticase
From FAERS, the FDA’s public side-effect reporting system (3,686 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Diatomaceous Earth
Browse every other medication we’ve checked against Diatomaceous Earth — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Diatomaceous Earth against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Amlodipine ›
- Levothyroxine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Methamphetamine ›
- Tirzepatide ›
- Docusate ›
- Ibuprofen ›
- Warfarin Sodium ›
- Sumatriptan ›
- Tadalafil ›
- Valacyclovir ›
- Isotretinoin ›
- Hydroxyurea ›
- Prednisone ›
- Amlodipine Besylate ›
- Semaglutide ›
- Metformin ›
- Lisdexamfetamine ›
- Propranolol ›
- Amitriptyline ›
- Methotrexate ›
- Amphetamine ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Bendamustine ›
- Levothyroxine, Liothyronine ›
- Pregabalin ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Gabapentin ›
- Dextroamphetamine ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Acetaminophen, Codeine ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Diatomaceous Earth list.
Diatomaceous Earth References
The 6 references that drive our Diatomaceous Earth monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Rushton L. Chronic obstructive pulmonary disease and occupational exposure to silica. Rev Environ Health 2007;22(4):255-72. PubMed
- Gallagher LG, Park RM, Checkoway H. Extended follow-up of lung cancer and non-malignant respiratory disease mortality among California diatomaceous earth workers. Occup Environ Med. 2015;72(5):360-5. PubMed
- Moisan S, Rucay P, Ghali A, Penneau-Fontbonne D, Lavigne C. Silica-associated limited systemic sclerosis after occupational exposure to calcined diatomaceous earth. Joint Bone Spine. 2010;77(5):472-3. PubMed
- Park R, Rice F, Stayner L, Smith R, Gilbert S, Checkoway H. Exposure to crystalline silica, silicosis, and lung disease other than cancer in diatomaceous earth industry workers: a quantitative risk assessment. Occup Environ Med. 2002;59(1):36-43. PubMed
- Nattrass C, Horwell CJ, Damby DE, Kermanizadeh A, Brown DM, Stone V. The global variability of diatomaceous earth toxicity: a physicochemical and in vitro investigation. J Occup Med Toxicol. 2015 10;10:23. PubMed
- Wachter H, Lechleitner M, Artner-Dworzak E, Hausen A, Jarosch E, Widner B, Patsch J, Pfeiffer K, Fuchs D. Diatomaceous earth lowers blood cholesterol concentrations. Eur J Med Res. 1998 8;3(4):211-5.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Diatomaceous Earth and Pegloticase Together: Common Questions
Is it safe to take Diatomaceous Earth with Pegloticase?
Does Pegloticase interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.